Mineral nutrients play an important role in plant-disease interactions. Experiments were conducted under Randomized Complete Block Design (RCBD) with three replications to find out the influence of macro and micro-nutrients with relation to the citrus canker caused by Xanthomonas axonopodis pv. citri (Xac). Mixture of nutrients NPK (Compound) and B, Zn, Fe, Mg, Mn and Ca (Nutritop) were evaluated under greenhouse and field conditions. In greenhouse experiment, combination of both Nutritop and Compound expressed very low disease incidence (16.27) as compared to other Compound (25.72), Nutritop (31.55) alone as well as control consistently. Treatments and concentrations interaction exhibited 21.33 % disease incidence which was expressed through Compound @ 6000 mL/ha as compared to 5000 (26.50) as well as 4000 mL/ha (29.33) percent while 1000, 1200 and 1400 mL/ha Nutritop concentrations exhibited 35.50, 31.83 and 27.33 % disease incidence consistently. Under field conditions, very low disease incidence (19.50, 17.50 and 11.83) % was recorded when (Compound + Nutritop) was applied at the rate of 3000, 4000 and 5000 mL/ha consistently. Compound with the Nutritop showed less disease incidence (20.27) in comparison to Compound (29.72), Nutritop (35.55) as well as control consistently. Treatments and concentrations interaction expressed 25.33% disease incidence was exhibited by Compound at the rate of 6000 mL/ha as compared to 5000 (30.50) as well as 4000 mL/ha (33.33) % while 1000, 1200 and 1400 mL/ha Nutritop concentrations showed 39.50, 35.83 and 31.33% disease incidence consistently.