#painresearch

[jboquiren]

This is one of several pen and ink illustrations for a book titled 'Mindful Yoga for Chronic Pain' due for publication later this year. #commission #bookillustrations #mindfulness #yoga #illustration #josephboquiren #painresearch #book #penandink (at Portland, Oregon) https://www.instagram.com/p/ByOInLPlqZ_/?igshid=f3h7fc7o7q4m

[inovineconferences]

2nd International Conference on Surgery & Anesthesia-2027

💙 Advancing Excellence in Pain Medicine & Pain Management

Join leading clinicians, anesthesiologists, pain specialists, surgeons, researchers and healthcare professionals at the 2nd International Conference on Surgery & Anesthesia-2027. 📅 April 09–10, 2027 📍 Zurich, Switzerland Featured Session: Pain Medicine & Pain Management

Explore the latest innovations in acute and chronic pain management, regional anesthesia, multimodal analgesia, interventional pain therapies, perioperative pain control and patient-centered care strategies.

🎯 Theme: Innovations Driving Excellence in Surgery and Anesthesia for Safer Patient Outcomes

Gain valuable insights, present your research and connect with global experts dedicated to improving pain care and enhancing patient recovery.

🔗 https://surgery.inovineconferences.com

📧 [email protected] 📱 WhatsApp: [phone]

[topscientists]

Advanced proteomics uncovers hidden neuroimmune interactions and dopamine pathway shifts across the nociceptive neuraxis in neuropathic pain. 🧠⚡ This research reveals molecular signatures behind chronic pain, opening doors for precision therapies, biomarker discovery, and targeted neuromodulation strategies that may transform future pain diagnosis, treatment, and neurobiological understanding.

World Top Scientists Awards

Visit Our Website 🌐: worldtopscientists.com

Nominate Now📝: https://worldtopscientists.com/award-nomination/?ecategory=Awards&rcategory=Awardee

Contact us ✉️: [email protected]

[lifesciencesmagazine]

Lab-Grown Human Nerve Circuit Offers Breakthrough Insight into Pain Perception

Source: Image by ParallelVision from pixabay

Scientists Recreate Human Pain Pathway in a Lab

In a groundbreaking study conducted by Stanford Medicine, researchers have successfully recreated a crucial Human Nerve sensory pathway in a laboratory dish. This artificial nerve circuit, called an “assembloid,” replicates the transmission of pain signals from the skin through the spinal cord to the brain. For the first time, scientists have been able to non-invasively observe the complete human ascending sensory pathway, which is responsible for carrying pain sensations.

The model is composed of four interconnected organoids, each representing a vital part of the nervous system: the dorsal root ganglion, dorsal spinal cord, thalamus, and somatosensory cortex. Senior researcher Dr. Sergiu Pasca, who has pioneered the use of brain organoids, said this new approach could open the door to more accurate pain research and better treatments. “We can now model this pathway non-invasively,” Pasca noted. “That will, we hope, help us learn how to better treat pain disorders.”

Unlike previous studies using animals, which often have pain mechanisms that differ from humans, this assembloid gives scientists a more reliable platform for studying human-specific neurological responses.

Testing Pain Signals and Genetic Mutations

To evaluate the functionality of the assembloid, researchers introduced pain-inducing substances like capsaicin—the active compound found in chili peppers—into the sensory region. This triggered spontaneous waves of neural activity that traveled through the spinal, thalamic, and cortical sections, effectively simulating real Human Nerve pain transmission.

The study also demonstrated how genetic mutations affect pain perception. Researchers introduced variations in the Nav1.7 sodium channel, a protein found mainly in peripheral sensory neurons. Mutations in this channel are known to either heighten pain sensitivity or eliminate pain perception altogether. When the mutant, pain-hypersensitive version of Nav1.7 was introduced, the assembloid showed intensified, synchronized neural activity. In contrast, disabling Nav1.7 disrupted this coordination—though neurons still fired, the overall signal failed to pass smoothly through the system.

These findings underscore the critical role of specific genes in pain disorders and demonstrate the assembloid’s potential for studying both inherited conditions and drug responses.

Future Potential in Chronic Pain and Drug Development

Pain remains one of the most widespread and challenging health issues globally. In the U.S. alone, over 116 million people suffer from chronic pain. Yet current treatments are limited, often relying on repurposed drugs or opioids, which carry a high risk of addiction.

Stanford’s new assembloid model offers a promising platform for identifying safer, more effective pain therapies. By targeting the sensory neurons involved in initiating pain signals—rather than the brain’s reward centers, which opioids affect—researchers aim to develop drugs that block pain without addictive side effects.

While the assembloid doesn’t “feel” pain itself, it accurately transmits sensory signals that mirror human physiological responses. As the model matures, scientists plan to use it to study pain-related neurodevelopmental disorders such as autism, which is often associated with sensory hypersensitivity.

With patents filed and backing from organizations such as the NIH and the Chan Zuckerberg Initiative, this groundbreaking work in Human Nerve research has the potential to revolutionize pain management and pave the way for advancements in neurological drug discovery.

[joelekm]

Pain and the Neuroimmune System with Luke Bongiorno

“Instead of just getting nociceptive information from that body part, you're getting other sensory information. You're changing the input to change the output.” - Luke Bongiorno 👉🏻 Our guest is Luke Bongiorno, PT, MCMT. Luke acquired the directorship of Noigroup in March 2021 from the founders David Butler and Juliet Gore. His physiotherapy journey began with a degree from The University of Melbourne, Australia, followed by a move into clinical practice in New York. In NYC, Luke co-founded New York Sports Medicine which Orthology later acquired. Still, one of New York City’s most prominent physical therapists,

[cabinetjustzen]

Traitement Trigger Points à 45,00€ Les « Trigger Points» (ou points gachettes) sont des points douloureux, des nœuds, qui se trouvent dans la musculature. Ils provoquent des douleurs lors de mouvements ou même au repos. Sans traitement, une personne qui souffre de « Trigger Points » risque d’en avoir de plus en plus. Un point peut provoquer d’autres soit juste à coté soit éloigné du point d’origine. Les trigger points ne s’en vont pas comme ils sont venus. Il faut un traitement spécifique pour en venir à bout. Prenez vite rendez-vous sur www.just-zen.lu #therapeuticmassage #massageluxembourg #painresearch #chronicpain #justzen ##MassageTherapistbackpain https://www.instagram.com/p/Bodh83dHGgo/?utm_source=ig_tumblr_share&igshid=15rncbo6wlyxm

[cabinetjustzen]

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Offrez-vous un massage adapté par nos massothérapeutes certifié(e)s Venez vivre une expérience massage professionnelle et personnalisée selon vos besoins! www.just-zen.lu #massagetechnique #therapeuticmassage #massageluxembourg #painresearch #chronicpain #justzen ##MassageTherapistbackpain #relaxation #relax #madeinluxembourg https://www.instagram.com/p/BoIwucjHLT-/?utm_source=ig_tumblr_share&igshid=1i079ioqgqwxb

[cabinetjustzen]

Just Zen Sarls est fier d'annoncer l'obtention du label "Made In Luxembourg". Depuis 1984, ce label est une marque enregistrée à l’initiative du Ministère des Affaires Étrangères, de la Chambre de Commerce et de la Chambre des Métiers luxembourgeoises. Son objectif ? Identifier l’origine luxembourgeoise des produits et services présents sur le marché national. Pourquoi ? Bien positionner et démarquer nos services vers nos clients est essentiel pour nous différencier, tant les marchés étrangers qu’au niveau national. Ainsi, le label “Made in Luxembourg” peut être considéré comme outil de promotion supplémentaire pour les entreprises luxembourgeoises qui veulent distinguer leurs produits et services notamment en soulignant leur origine luxembourgeoise. Quelle valeur ajoutée pour Just Zen Sarls ? Réaffirmer notre fierté et notre plaisir de travailler au Luxembourg, proches de nos clients en soulignant la parfaite connaissance que nous avons des bonnes pratiques locales, des fournisseurs et des règlementations. www.just-zen.lu #therapeuticmassage #massageluxembourg #painresearch #chronicpain #justzen ##MassageTherapist #relaxation #relax #MadeInLuxembourg #luxembourgcity https://www.instagram.com/p/BnVhDnTHeSG/?utm_source=ig_tumblr_share&igshid=1g5qm5ypm6wwa