This occurs somewhere after RE Village. I imagine between losing Ethan, the BSAA betrayal and Mia lying about Ethan and jeopardising his safety, Chris is fucking broken.
I also imagine Leon started going grey before Chris. RE village was set 2021 and Chris is allllllllll dark there. Leon 100% started going grey after Death Island 😅
Imma say it, I don't like Mia. Not only did she actively partake in the imprisonment and manipulation of an unethically created being. But after shit hit the fan and she SHOULD have learnt her lesson, she proceeded to hide Ethan's condition from Chris AND had an morally wrong and unethical child with a man who was technically a BOW. She continued to put Ethan, and by extension Rose, in harms way.
And given the DLC we see for Village, how Rose's attitude towards Chris is, I wouldn't be surprised if Mia had a hand in that too.
So not only does Chris now have to deal with Mia, with questionable loyalty and in her own selfish way, blames Chris for shit out of his control, but he's also gotta deal with a BOW temperamental child/teenager whose probably had her mother whispering in her ear.
So yeah, poor dude is fucking FEELING it.