Calcium Acetate
Brand Name: Phoslo
Generic Available
Common Dosage Forms:
Capsules: 667 mg
Tablets: 667 mg
FDA Indications/Dosages:
For the reduction of serum phosphorus in patients with end stage renal disease: Begin with 2 capsules/tablets given with each meal. Titrate dose 2-3 weeks until the desired serum phosphorus level is reached (serum phosphate <6 mg/dL). Usual adult dose is 3 to 4 capsules/tablets with each meal.
Monitor: Serum phosphorus, serum calcium.
Pharmacology/Pharmacokinetics: Patients with end-stage renal disease (ESRD) are susceptible to develop hyperphosphatemia. High serum phosphorus levels can precipitate calcium and cause painful ectopic calcification. High serum phosphorus levels in patients with ESRD may also contribute to the development of secondary hyperparathyroidism. Calcium acetate combines with dietary phosphate to form an insoluble calcium phosphate complex, decreasing serum phosphorus levels. The calcium phosphate complex is excreted in the feces.
Drug Interactions: May decrease the bioavailability of tetracyclines and fluoroquinolones. It is recommended to take calcium acetate capsules one hour before three hours following any medication in which bioavailability is in question. Secondary hypercalcemia may increase digitalis toxicity.
Contraindication/Precautions: Contraindicated in patients with hypercalcemia. Avoid the use of calcium supplements, including calcium-based antacids, with calcium acetate. Monitor serum calcium regularly, especially during initiation of treatment. The serum calcium times phosphate (CaxP) product should not exceed 66. Symptoms of mild hypercalcemia include nausea, vomiting, constipation, and anorexia. Severe hypercalcemia leads to stupor, delirium, confusion, and come. Pregnancy Category C.
Adverse Effects: The most common adverse effects are nausea, vomiting, and hypercalcemia.
Patient Consultation:
Take with food or meals.
If a dose is missed, skip it and return to normal dosing schedule.
Do not discontinue therapy without first consulting physician.
Contact a physician if the above side effects are severe or persistent.
Do not take additional calcium supplements.