#professionaldentaleclass

[dentistryzone1]

Diagnosis?? 🤔 ▪️▪️▪️▪️ #oralpathology #oralmedicine #oraldiagnosis #professionaldentaleclass 'Pediatria Polska Vol 90(2), 2015, pp 155-160' (à Lausanne, Switzerland) https://www.instagram.com/p/CBNTQzbADpy/?igshid=1w42nm0ybr6zu

[dentistryzone1]

Lingual Neurofibroma as an oral manifestation of the VON RECKLINGHAUSEN DISEASE or Neurofibromatosis type 1 (NF-1). NF-1 is an autosomal dominant neuropathology that is characterized by peripheral nerve sheath tumours, neurofibromas, café-au-lait pigmentations and pigmented hamartomas of the iris (Lisch nodules). NF-1 is quite common and the familial penetrance is complete. Neurofibromin, the tumour suppressor protein product of the NF-1 gene (on chromosome 17q) is non-functional in the disease, with a consequence of uncontrolled activity of the mitogenic MAP-Kinase molecular pathway. The resulting tumours are mostly benign but malignant transformation is not uncommon. Since the MAP-K pathway is a common intracellular pathway used in cell division and proliferation, non-neural tumours (benign and malignant) may develop concomitantly. Management involves surgical removal and genetic counselling for the patient and family. #oralpathology #oralmedicine #oraldiagnosis #professionaldentaleclass #nf1 #neurofibromatosis 'J of Oral and Max Surg, Med, and Path Vol 29(5),2017, pp 430-433' (à Lausanne, Switzerland) https://www.instagram.com/p/B5TCCGUgBal/?igshid=snvavvi4tgpb