SBIR Program News Today: NIST Awards $3.19M Phase II grant
NIST invests $3.19 million in small business innovation for quantum, AI, and biotechnology.
SBIR program news today
Eight small businesses received about £2.5 million from NIST to foster high-tech prototyping. SBIR's AI, medical diagnostics, and quantum technology initiative focuses on critical industries. These Phase II grants allow entrepreneurs to prototype their concepts in two years. Scalable quantum light sources, cybersecurity assessment tools, and new imaging technologies are supported. The Commerce Department funds this study to ensure commercial viability. They increase energy efficiency, public health, and national security through private innovation.
The competitively selected projects aspire to commercialize and receive non-SBIR Phase III financing by developing Phase I concepts into functioning prototypes.
Standardizing biopharmaceuticals and medical imaging
Biotechnology and healthcare, which require regularity and accuracy, receive most financing. Madison, Wisconsin-based Calimetrix LLC received $399,998 to improve medical imaging accuracy. The company is generating human-like imaging "phantoms" to simulate fatty liver tissue. These phantoms allow researchers and physicians to standardize MRI and CT scan comparisons across vendor platforms, ensuring consistent patient data regardless of scan site.
Quincy, Massachusetts-based Applied Imaging Solutions LLC will receive $400,000 to modernize biopharmaceutical cell culture monitoring in medication manufacture. Current cell culture upkeep requires intensive manual observation. Applied Imaging Solutions is developing an AI-powered system for contactless cell viability and metabolite level measurement using SWIR-HSI. It improves bioreactor control to make life-saving medications safer and more efficient.
Nano-Simulation and Quantum Interconnect Improvements
Boulder-based Icarus Quantum Inc. received a grant from NIST, demonstrating its commitment to quantum technologies. With $400,000, the company built a semiconductor quantum dot photon source. This scalable system integrates numerous high-efficiency photon sources on a chip. It is designed as a “plug-and-play” approach to let researchers integrate quantum interconnects into their systems, advancing quantum computing and networking.
Software from Schenectady, New York-based AMAG Consulting LLC supports these hardware advances. AMAG is enhancing its SimuSEM program, which models electron beam interactions with scanning electron microscope materials, with a $400,000 funding. Surface roughness, magnetic interactions, and charging effects are modeled in Phase II. These enhancements will allow scientists to take more exact nanoscale photographs, reducing the need for costly physical testing.
Monitoring the Environment and Cybersecurity
SBIR also addresses digital safety and the environment. Philadelphia-based MyExposome Inc. will receive $395,814.74 to improve wearable environmental sensors. The company uses silicone wristbands to detect PFAS exposure, sometimes known as "forever chemicals." MyExposome is developing solvent-free extraction technologies to identify more PFAS and make environmental research and health assessments more cheap.
San Diego-based ObjectSecurity LLC raised $399,908.58 online to develop the Operational Technology Artificial Intelligence – NIST Compliance Tool (OTAI-NCT). This cybersecurity tool evaluates software and hardware manufacturer policies using reputable sources like the National Vulnerability Database. The final “cyber-hygiene score” helps buyers make informed purchases and protects public safety and national security.
Optical Imaging Resolution and Energy Efficiency
General imaging resolution and infrastructure projects complete Phase II awardees. Harpers Ferry, West Virginia-based Universal Schedule and Booking LLC received $400,000 to build an intelligent digital home energy management system. Their method estimates household energy usage without expensive hardware sensors, overcoming a major barrier to energy-saving technology adoption.
HighRI Optics Inc. in Oakland, California, received $399,858.96 for developing a binary pseudo-random array (BPRA) for optical image enhancement. With this invention, scientific, manufacturing, and military imaging equipment will have improved resolution.
Looking Ahead
The eight initiatives demonstrate the US innovation economy's diversity. NIST helps small businesses complete the 24-month Phase II R&D cycle to create power grid resilience and cancer detection technology. As they accomplish milestones, these firms will aim for Phase III, where they can market their discoveries.
Which program is SBIR?
SBIR (Small Business Innovation Research) is a U.S. government program that provides competitive funding (grants, contracts) to small businesses for R&D of innovative technologies with commercial potential, providing early-stage tech funding and boosting economic growth by connecting small firms to federal R&D needs. It's administered by 11 federal agencies and often paired with STTR (Small Business Technology Transfer) to help develop new products and processes while allowing businesses to retain equity. Funding is typically provided in three phases: feasibility, R&D/prototype, and commercialization.















