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We need the following material: 8,8'-(propane-2,2-diyl)bis(2,3,6,7-tetrahydro-1H,5H-pyridoquinoline) CAS CAS Number: 2393950-97-3 - Product Name: 8,8'-(propane-2,2-diyl)bis(2,3,6,7-tetrahydro-1H,5H-pyridoquinoline)CAS Number: 2393950-97-3Required Amount:10gOther Information: NoneContact Us: 1. WhatsApp: +1 90180093392. Line: chemwhatorg3. WeChat: chemwhat4. Email: [email protected]. Website: www.chemwhat.orgFollow our latest purchase information：1. Website: chemwhat.org2. Subscribe to our email or SMS newsletters3. Follow us by social media:Whatsapp Channel: whatsapp.com/channel/0029VaL4Tl5L2ATrsOyP541dLine Official Account: page.line.me/352ynrycWeChat Official Account: https://mp.weixin.qq.com/s/BTcDAXw5OXFIDTYoyDDkMgFacebook: facebook.com/chemwhatsourcingTwitter: twitter.com/chemwhatorgLinkedin: linkedin.com/company/chemwhatorg Read the full article
Landscaping of Quinoline based Heterocycles as Potential Antimicrobial Agents: A Mini Review-Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF DRUG DESIGNING & DEVELOPMENT
Abstract
In this mini-review, we have compiled our research group's prior efforts aimed at developing potential, novel and safe antimicrobial agents with improved efficiency by using the hybrid molecular approach on quinoline hybrids. Present mini-review article deals with landscaping of quinoline based bioactive analogues with pyrazoles, thiazoles, 4-thiazolidinones, pyrimidines and 2-pyridones heterocycles. Quinoline motifs containing hybrids with two or more fold antimicrobial activity are described hereby. We have reported a mini review of 174 compounds prepared in our laboratory. The SAR of the most promising compounds is also discussed.
Keywords: Quinoline; Antimicrobial agents; Pyrazole; 4-Thiazolidinone; 2-Pyridone
Abbrevations: AC: Aspergillus Clavatus; An: Aspergillus Niger; Ca: Candida Albicans; Ec: Escherichia Coli; Pa: Pseudomonas Aeruginosa; Sa: Staphylococcus Aureus; Sp: Streptococcus Pyogenes
Introduction
The ever swelling incidences of infectious resistance pose a major threat to the scientific society and thus the basic requirement for discovery and development of newer and safer anti-microbial agents with novel mode of action is becoming acute [1]. One of the best ways to tackle this type of enormous problem is to synthesize hybrid molecules by uniting two or more bioactive heterocyclic moieties in a single molecular framework. Libraries of privileged heterocyclic structures can be used in place of modified drugs. In continuation to this, the design of molecules is made in such a way that may have lower adverse effects with shorter treatment regimens [2].
Quinoline is a heterocyclic aromatic organic compound having molecular formula C9H7N, possessed by a double-ring structure containing a benzene ring fused to pyridine at two adjacent carbon atoms [3]. Quinoline is a core pharmacophore in the recently developed anti tubercular drugs bedaquiline (TMC207). This is the first drug with a novel mechanism of action for TB in more than 40 years. Bedaquiline a diarylquinoline is the sole drug specifically indicated to treat MDR-TB [4]. It works via inhibition of enzyme adenosine triphosphate (ATP) synthase, which is the energy source for the bacterium. Furthermore, quinoline moiety exhibits biological activities like antibacterial [5], anti-malarial [6], anti-TB [7], anti-proliferative [8] and anti cancer [9].
*MIC (in μg/mL) of standard drug Ampicillin against: Ec (MTCC-443): 100; Pa (MTCC-1688): 100; Sa (MTCC-96): 250; Sp (MTCC 442): 100 & Griseofulvin against: An (MTCC-282): 100; Ac (MTCC-1323): 100.
According to literature survey, more potent novel chemical entities can be envisaged by uniting two or more heterocyclic systems into a single molecule [10]. With the aim of developing new affordable antimicrobials having new mode of action, our research group is actively involved in developing novel hybrid heterocycles and screen them for antimicrobial activity with some more promising results. We have further modified active molecules to develop compounds with more potency and less toxicity. In this article we report here published results of our effort towards development of more potential antimicrobial agents. Since a couple of years our research group has published several important findings for the benefit of scientific community on quinoline based heterocycles. Previously we have published review articles of our own findings which received very well appreciation by scientific community [11,12] (Table 1).
Quinoline clubbed pyrazole motifs - (Compounds 1-51)
Looking at the versatile biological portfolios of quinoline; pyrazole with 4-thiazolidinones and pyridine heterocyclic ring systems, new structural hybrids of three moieties were prepared and subjected to antimicrobial activity [13-15]. Quinoline-pyrazole hybrids 1-15 and 16-51 are shown in Figure 1. Compounds 1-15 substituted with H at R and 2-Cl, 4-Cl, 4-F and 4-NO2 at R1 position, compounds 4, 5, 6 and 14 came out as most potent antimicrobial agents with MIC of 12.5μg/ mL against various bacterial and fungal strains. Compound 15 displayed excellent antibacterial and antifungal activities against Staphylococcus aureus and Aspergillus niger with MIC of 12.5μg/mL. From the series of compounds 16-51, compound 27 (R=H and R1=4-NO2) stood out as most promising antibacterial as well as antifungal potency with MIC of 12.5μg/mL against P aeruginosa and A. clavatus respectively. Nitro group at ortho position in compounds 37 (R=6-CH3) and 49 (R=6-F) were identified as a most active antimicrobial agents with MIC of 12.5μg/mL against P. aeruginosa and A. clavatus strains taking Ampicillin and Griseofulvin as standard drugs.
Quinoline clubbed thiazole motifs - (Compounds 52–78)
A series of quinoline clubbed thiazole motifs were synthesized and subjected to antimicrobial evaluation [16,17]. Hybrid structure is depicted in Figure 1. Compound 59 (R=H) containing 3,4,5-(OCH3)3 group showed excellent inhibition (25μg/mL) against P aeruginosa bacterial strain as compared to the standard drug Gentamycin. Compounds 74 and 78 (R= 8-CH3) containing electron withdrawing substituents such as -Cl and -F exhibited good antimicrobial activity. It is a well-known fact that electron withdrawing substituents increase the lipophilicity of molecules. This property is directly related to antimicrobial activity as it helps the compound to diffuse through biological membranes and reach the site of action (Table 2).
*aMIC (in μg/mL) of standard drug Gentamycin against: Pa (MTCC- 1688): 0.5
*bMIC (in μg/mL) of standard drug Ampicillin against: Pa (MTCC- 1688): 100 & Griseofulvin against: Ac (MTCC-1323): 100.
Quinoline clubbed 4-thiazolidinone motifs - (Compounds 79-100)
*MIC (in μg/mL) of standard drug Ampicillin against: Sp (MTCC 442): 100 & Griseofulvin against: An (MTCC-282): 100.
Owing to the pharmacological importance of 4-thiazolidinones and quinoline, we synthesized new quinoline derivatives containing 4-thiazolidinone moiety and screened them for antimicrobial activity [18-19]. Quinoline containing 4-thiazolidinone structural hybrids were shown in Figure 1 (Compounds 79-100). Compound 86 substituted with 8-OCH3 at R and H at R1 position displayed MIC of 12.5 and 25μg/ mL against S. pyogenes and A. niger respectively. Compound 97 exhibited maximum antibacterial inhibition (12.5μg/mL) against S. pyogenes using Ampicillin as standard drug. SAR studies revealed that substitution on quinoline ring at 8th position by an electron releasing groups seems to be better than that of electron withdrawing substitutions (Table 3).
Quinoline clubbed pyrimidine motifs - (Compounds 101-151)
Pyrimidine analogues play a vital role in drug discovery and its development process, and have significant pharmacological reputation. In view of broad spectrum biological activities of quinolines and pyrimidines, we designed and synthesized new prototypes of quinoline and pyrimidine nucleus in a single molecular framework and successively evaluated them for antimicrobial activity [20-22]. Structures of quinoline pyrimidine hybrid are represented in Figure 1 (Compounds 101-136 and 137-151). Compound 112 (R=H and R1= 4-NO2) demonstrated the most potent antibacterial activity with MIC of 12.5 μg/mL against E. coli and S. pyogenes. Compounds 121 (R=6-Cl and R1=4-F) and 122 (R= 6-Cl and R1=2-NO2) were identified as the most potent antifungal as well as antibacterial agents with MIC of 12.5μg/mL, respectively. Compound 131 (R= 6-F and R1=2-F) exhibited maximum inhibition against E. coli. It was observed on the basis of SAR studies that high antimicrobial properties of these compounds may be attributed to the presence of electron withdrawing substituents such as nitro and fluoro at phenyl ring of pyrimidine nucleus. On the other hand, compounds 147 and 149 contain electron donating substituents at para position showed 12.5μg/mL MIC against Staphylococcus pyogenes and Staphylococcus aureus. In-vitro cytotoxicity of most active antimicrobial compounds 147 (R=6-Cl and R1=4-OH) and 149 (R=6-Cl and R1=4-OCH3) were evaluated against human cervical cancer cell line (HeLa) by MTT colorimetric assay and the tested compounds exhibited any significant cytotoxic effect on HeLa cells, suggesting a great potential for their in-vivo use as antimicrobial agents (Table 4).
*aMIC (in μg/mL) of standard drug Ampicillin against: Ec (MTCC-443): 100; Sp (MTCC 442): 100
*bMIC (in μg/mL) of standard drug Ciprofloxacin against: Ec (MTCC- 443): 25; Sp (MTCC 442): 50; Sa (MTCC-96): 50 & Griseofulvin against: Ac (MTCC-1323): 100.
Quinoline clubbed 2-pyridone motifs - (Compounds 152-174)
Rich biological silhouette of quinoline and 2-pyridone analogues gave us an impetus to design, synthesis and evaluate new structural hybrids of both these nucleus in single platform [23,24]. Quinoline-2-pyridone hybrid is displayed in Figure 1 with compound 152-174. Compound 153 endowed with 4-CH3 substituent revealed remarkable MIC of 62.5μg/mL against bacterial strain of E. coli as compared to the standard drug Gentamycin in. From antibacterial activity data, it was observed that compounds 163 (R=6-Cl and R1=4-CH3) and 164 (R=6-Cl and R1=4-OCH3) were identified as most active compounds (MIC=12.5μg/mL) against various Gram-negative as well as Gram-positive bacterial strains. 3-OH analogue possessed maximum inhibition at 12.5μg/mL against Candida albicans fungal strain (Table 5).
*aMIC (in μg/mL) of standard drug Gentamycin against: Ec (MTCC-443): 0.25
*bMIC (in μg/mL) of standard drug Ciprofloxacin against: Ec (MTCC-443): 25; Pa (MTCC 1688): 25; Sa (MTCC-96): 50 & Griseofulvin against: Ca (MTCC-227): 500.
Conclusion
Current article discusses the principle idea for co-relating the structures of potent heterocyclic molecules and antimicrobial activity. The quinoline based molecule classes reported here are pyrazoles, thiazoles, 4-thiazolidinones, pyrimidines and 2-pyridones. Our endeavours to design, synthesis and examine novel quinoline based structural hybrids of various bioactive heterocycles as potential antimicrobial agents have yielded promising results in primary biological evaluation. In our forthcoming efforts, we will assess these structural hybrids and their modified derivatives for further in-vivo studies. The most potent compounds will be validated against various available molecular targets with the goal to produce novel antimicrobial agents with superior remedial effect, minor toxicity and less side effects.
Acknowledgement
Authors are gratified to the UGC, New Delhi and Department of Science and Technology, New Delhi (DST-FIST-SR/FST/CSI- 212/2010) for financial support under the NON-SAP and DST FIST programs, respectively. Dr. Bonny Y Patel is thankful to CSIR (CSIR EMR-II 02(0188)14/EMR-II), New Delhi for CSIR EMR-II Research Associate-I and Mr. Krunalsinh A Jadeja is thankful to UGC, New Delhi for UGC-MRP Project Fellowship (UGC F. No.-43- 164/2014(SR)).
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Landscaping of Quinoline based Heterocycles as Potential Antimicrobial Agents: A Mini Review-Open Access Publishers Novel Approaches in Drug Designing & Development (NAPDD)
In this mini-review, we have compiled our research group's prior efforts aimed at developing potential, novel and safe antimicrobial agents with improved efficiency by using the hybrid molecular approach on quinoline hybrids. Present mini-review article deals with landscaping of quinoline based bioactive analogues with pyrazoles, thiazoles, 4-thiazolidinones, pyrimidines and 2-pyridones heterocycles. Quinoline motifs containing hybrids with two or more fold antimicrobial activity are described hereby. We have reported a mini review of 174 compounds prepared in our laboratory. The SAR of the most promising compounds is also discussed.
Keywords: Quinoline; Antimicrobial agents; Pyrazole; 4-Thiazolidinone; 2-Pyridone
Abbrevations: AC: Aspergillus Clavatus; An: Aspergillus Niger; Ca: Candida Albicans; Ec: Escherichia Coli; Pa: Pseudomonas Aeruginosa; Sa: Staphylococcus Aureus; Sp: Streptococcus Pyogenes
Introduction
The ever swelling incidences of infectious resistance pose a major threat to the scientific society and thus the basic requirement for discovery and development of newer and safer anti-microbial agents with novel mode of action is becoming acute [1]. One of the best ways to tackle this type of enormous problem is to synthesize hybrid molecules by uniting two or more bioactive heterocyclic moieties in a single molecular framework. Libraries of privileged heterocyclic structures can be used in place of modified drugs. In continuation to this, the design of molecules is made in such a way that may have lower adverse effects with shorter treatment regimens [2].
Quinoline is a heterocyclic aromatic organic compound having molecular formula C9H7N, possessed by a double-ring structure containing a benzene ring fused to pyridine at two adjacent carbon atoms [3]. Quinoline is a core pharmacophore in the recently developed anti tubercular drugs bedaquiline (TMC207). This is the first drug with a novel mechanism of action for TB in more than 40 years. Bedaquiline a diarylquinoline is the sole drug specifically indicated to treat MDR-TB [4]. It works via inhibition of enzyme adenosine triphosphate (ATP) synthase, which is the energy source for the bacterium. Furthermore, quinoline moiety exhibits biological activities like antibacterial [5], anti-malarial [6], anti-TB [7], anti-proliferative [8] and anti cancer [9].
*MIC (in μg/mL) of standard drug Ampicillin against: Ec (MTCC-443): 100; Pa (MTCC-1688): 100; Sa (MTCC-96): 250; Sp (MTCC 442): 100 & Griseofulvin against: An (MTCC-282): 100; Ac (MTCC-1323): 100.
According to literature survey, more potent novel chemical entities can be envisaged by uniting two or more heterocyclic systems into a single molecule [10]. With the aim of developing new affordable antimicrobials having new mode of action, our research group is actively involved in developing novel hybrid heterocycles and screen them for antimicrobial activity with some more promising results. We have further modified active molecules to develop compounds with more potency and less toxicity. In this article we report here published results of our effort towards development of more potential antimicrobial agents. Since a couple of years our research group has published several important findings for the benefit of scientific community on quinoline based heterocycles. Previously we have published review articles of our own findings which received very well appreciation by scientific community [11,12] (Table 1).
Quinoline clubbed pyrazole motifs - (Compounds 1-51)
Looking at the versatile biological portfolios of quinoline; pyrazole with 4-thiazolidinones and pyridine heterocyclic ring systems, new structural hybrids of three moieties were prepared and subjected to antimicrobial activity [13-15]. Quinoline-pyrazole hybrids 1-15 and 16-51 are shown in Figure 1. Compounds 1-15 substituted with H at R and 2-Cl, 4-Cl, 4-F and 4-NO2 at R1 position, compounds 4, 5, 6 and 14 came out as most potent antimicrobial agents with MIC of 12.5μg/ mL against various bacterial and fungal strains. Compound 15 displayed excellent antibacterial and antifungal activities against Staphylococcus aureus and Aspergillus niger with MIC of 12.5μg/mL. From the series of compounds 16-51, compound 27 (R=H and R1=4-NO2) stood out as most promising antibacterial as well as antifungal potency with MIC of 12.5μg/mL against P aeruginosa and A. clavatus respectively. Nitro group at ortho position in compounds 37 (R=6-CH3) and 49 (R=6-F) were identified as a most active antimicrobial agents with MIC of 12.5μg/mL against P. aeruginosa and A. clavatus strains taking Ampicillin and Griseofulvin as standard drugs.
Quinoline clubbed thiazole motifs - (Compounds 52–78)
A series of quinoline clubbed thiazole motifs were synthesized and subjected to antimicrobial evaluation [16,17]. Hybrid structure is depicted in Figure 1. Compound 59 (R=H) containing 3,4,5-(OCH3)3 group showed excellent inhibition (25μg/mL) against P aeruginosa bacterial strain as compared to the standard drug Gentamycin. Compounds 74 and 78 (R= 8-CH3) containing electron withdrawing substituents such as -Cl and -F exhibited good antimicrobial activity. It is a well-known fact that electron withdrawing substituents increase the lipophilicity of molecules. This property is directly related to antimicrobial activity as it helps the compound to diffuse through biological membranes and reach the site of action (Table 2).
*aMIC (in μg/mL) of standard drug Gentamycin against: Pa (MTCC- 1688): 0.5
*bMIC (in μg/mL) of standard drug Ampicillin against: Pa (MTCC- 1688): 100 & Griseofulvin against: Ac (MTCC-1323): 100.
Quinoline clubbed 4-thiazolidinone motifs - (Compounds 79-100)
*MIC (in μg/mL) of standard drug Ampicillin against: Sp (MTCC 442): 100 & Griseofulvin against: An (MTCC-282): 100.
Owing to the pharmacological importance of 4-thiazolidinones and quinoline, we synthesized new quinoline derivatives containing 4-thiazolidinone moiety and screened them for antimicrobial activity [18-19]. Quinoline containing 4-thiazolidinone structural hybrids were shown in Figure 1 (Compounds 79-100). Compound 86 substituted with 8-OCH3 at R and H at R1 position displayed MIC of 12.5 and 25μg/ mL against S. pyogenes and A. niger respectively. Compound 97 exhibited maximum antibacterial inhibition (12.5μg/mL) against S. pyogenes using Ampicillin as standard drug. SAR studies revealed that substitution on quinoline ring at 8th position by an electron releasing groups seems to be better than that of electron withdrawing substitutions (Table 3).
Quinoline clubbed pyrimidine motifs - (Compounds 101-151)
Pyrimidine analogues play a vital role in drug discovery and its development process, and have significant pharmacological reputation. In view of broad spectrum biological activities of quinolines and pyrimidines, we designed and synthesized new prototypes of quinoline and pyrimidine nucleus in a single molecular framework and successively evaluated them for antimicrobial activity [20-22]. Structures of quinoline pyrimidine hybrid are represented in Figure 1 (Compounds 101-136 and 137-151). Compound 112 (R=H and R1= 4-NO2) demonstrated the most potent antibacterial activity with MIC of 12.5 μg/mL against E. coli and S. pyogenes. Compounds 121 (R=6-Cl and R1=4-F) and 122 (R= 6-Cl and R1=2-NO2) were identified as the most potent antifungal as well as antibacterial agents with MIC of 12.5μg/mL, respectively. Compound 131 (R= 6-F and R1=2-F) exhibited maximum inhibition against E. coli. It was observed on the basis of SAR studies that high antimicrobial properties of these compounds may be attributed to the presence of electron withdrawing substituents such as nitro and fluoro at phenyl ring of pyrimidine nucleus. On the other hand, compounds 147 and 149 contain electron donating substituents at para position showed 12.5μg/mL MIC against Staphylococcus pyogenes and Staphylococcus aureus. In-vitro cytotoxicity of most active antimicrobial compounds 147 (R=6-Cl and R1=4-OH) and 149 (R=6-Cl and R1=4-OCH3) were evaluated against human cervical cancer cell line (HeLa) by MTT colorimetric assay and the tested compounds exhibited any significant cytotoxic effect on HeLa cells, suggesting a great potential for their in-vivo use as antimicrobial agents (Table 4).
*aMIC (in μg/mL) of standard drug Ampicillin against: Ec (MTCC-443): 100; Sp (MTCC 442): 100
*bMIC (in μg/mL) of standard drug Ciprofloxacin against: Ec (MTCC- 443): 25; Sp (MTCC 442): 50; Sa (MTCC-96): 50 & Griseofulvin against: Ac (MTCC-1323): 100.
Quinoline clubbed 2-pyridone motifs - (Compounds 152-174)
Rich biological silhouette of quinoline and 2-pyridone analogues gave us an impetus to design, synthesis and evaluate new structural hybrids of both these nucleus in single platform [23,24]. Quinoline-2-pyridone hybrid is displayed in Figure 1 with compound 152-174. Compound 153 endowed with 4-CH3 substituent revealed remarkable MIC of 62.5μg/mL against bacterial strain of E. coli as compared to the standard drug Gentamycin in. From antibacterial activity data, it was observed that compounds 163 (R=6-Cl and R1=4-CH3) and 164 (R=6-Cl and R1=4-OCH3) were identified as most active compounds (MIC=12.5μg/mL) against various Gram-negative as well as Gram-positive bacterial strains. 3-OH analogue possessed maximum inhibition at 12.5μg/mL against Candida albicans fungal strain (Table 5).
*aMIC (in μg/mL) of standard drug Gentamycin against: Ec (MTCC-443): 0.25
*bMIC (in μg/mL) of standard drug Ciprofloxacin against: Ec (MTCC-443): 25; Pa (MTCC 1688): 25; Sa (MTCC-96): 50 & Griseofulvin against: Ca (MTCC-227): 500.
Conclusion
Current article discusses the principle idea for co-relating the structures of potent heterocyclic molecules and antimicrobial activity. The quinoline based molecule classes reported here are pyrazoles, thiazoles, 4-thiazolidinones, pyrimidines and 2-pyridones. Our endeavours to design, synthesis and examine novel quinoline based structural hybrids of various bioactive heterocycles as potential antimicrobial agents have yielded promising results in primary biological evaluation. In our forthcoming efforts, we will assess these structural hybrids and their modified derivatives for further in-vivo studies. The most potent compounds will be validated against various available molecular targets with the goal to produce novel antimicrobial agents with superior remedial effect, minor toxicity and less side effects.
Acknowledgement
Authors are gratified to the UGC, New Delhi and Department of Science and Technology, New Delhi (DST-FIST-SR/FST/CSI- 212/2010) for financial support under the NON-SAP and DST FIST programs, respectively. Dr. Bonny Y Patel is thankful to CSIR (CSIR EMR-II 02(0188)14/EMR-II), New Delhi for CSIR EMR-II Research Associate-I and Mr. Krunalsinh A Jadeja is thankful to UGC, New Delhi for UGC-MRP Project Fellowship (UGC F. No.-43- 164/2014(SR)).
For more Open Access Journals in Juniper Publishers please click on: https://juniperpublishers.com
For more articles in Novel Approaches in Drug Designing & Development
please click on: https://juniperpublishers.com/napdd/index.php
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EPM Podcast 45 – Quinoline Yellow: tracklist Tatamax - LDLD IV (Uchelfa) Steve Reich - The Four Sections (Andrea Parker Remix) (Nonesuch) Autechre - Silverside (Warp) The Legendary Pink Dots - 834 (Beta-lactam Ring) Future Sound of London - Max (Astralwerks) Chris Morris & Peter Cook - Eels, Love and Guns (BBC Radio Collection) West Philips - Sucker For a Pretty Face (Vocal) (Quality) Boards of Canada - Nlogax (SKAM) Zoviet:France - Mana (Charrm) Aphex Twin - Untitled (Warp) Aphex Twin - On (28 Mix) (Warp) Stars of the Lid - The Artificial Pine Arch Song (Kranky) Chris Clark - Shonny (Warp) Firefox & 4-Tree - Warning (Powder Mix) (Philly Blunt) FBD Project - The Core (Johnny Jungle Remix) (Bang-In Tunes) Photek - Ni-Ten-Ichi-Ryu (Science) Autechre - Altibzz (Warp) Kool Keith - Regular Girl (Funky Ass) Vulva - Birdwatch (Rephlex) Push Button Objects - Lockligger (Schematic) Whitney Houston - I Wanna Dance With Somebody (Who Loves Me) (Acapella) (Arista) The Conet Project - Phonetic Alphabet - NATO (Irdial Discs) Tatamax - Ebychiad64 (Uchelfa) The Conet Project - NNN Hungarian (Irdial Discs) Astrobotnia - Lightworks (Rephlex) Duplo_Remote - Begin Message Map [-] (Unreleased) Aphex Twin - Btoum-Roumada (Warp) Alder & Elius - Albino Love (The Consumers Research & Development) Geraint Ffrancon - Night Remixes (Quinoline Yellow Remix) (Electroneg) Peppatits - 19/02/08 (Resonance FM Podcasts) Tangerine Dream - Rubycon Part 2 (Virgin) Blame & Justice - Essence (The Jazz Testament) (Moving Shadow) Unknown - Instant Confidence - (Unknown)