Disintegration Properties and Drug Release Profiles of Sodium Alginate Films Containing Rebamipide_Crimson Publishers
Disintegration Properties and Drug Release Profiles of Sodium Alginate Films Containing Rebamipide by Yoshifumi Murata* in Crimson Publishers: Peer Reviewed Material Science Journals
Film Dosage Forms [FDs] prepared using water-soluble polymers are a strategy for drug delivery to local disease sites. In this study, we prepared FDs incorporating rebamipide as a model drug using various types of sodium alginates [Alg-Nas] as the film base via the casting method. Both the dissolution profile of each FD and the drug dissolution profile from the FD were investigated in a limited amount of physiological saline. A thin film incorporating rebamipide was obtained when either 2-4% low-molecular-weight Alg-Na or 1.5% high-molecular-weight Alg-Na containing chitin were used as the film base. When the FD was brought in contact with the test medium, the film matrix swelled and disintegrated. The disintegration profile of the FD differed according to the type of Alg-Na. However, the disintegration of the FD film matrix did not affect the drug dissolution rate. All materials used for the preparation of the FDs were selected according to their safety for oral administration; therefore, FDs may be an attractive therapeutic form for use in the oral cavity.
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