(Bungarus flaviceps) red-headed krait
The red-headed krait is an extremely venomous snake, although bites are reported rarely. Krait venom appears to function primarily as a neurotoxin, preventing communication across neuromuscular synapses, causing paralysis and death by asphyxiation because the victims can no longer breathe on their own. When the venom from the red-headed krait takes effect, the most highly innervated muscles are the first to suffer: the muscle that elevates the upper eyelid and the ocular and ciliary muscles controlling the lens. Between 20 minutes and several hours after being bitten, the victim may have a real struggle to keep his or her eyelids open. This medical condition is known as bilateral ptosis and it is a classic, tell-tale sign of severe envenomation. Other common symptoms include diplopia, dysphagia, vomiting, headache, and hypersalivation. Sometime later the symptoms of paralysis tend to worsen, with progressive involvement of various muscles, including those of the jaws, in some cases, become locked. Respiratory distress may occur as a result of paralysis of the diaphragm, the main muscle controlling breathing. Its venom also contains a novel postsynaptic neurotoxin, termed κ-flavitoxin, which is a potent inhibitor of nicotinic transmission in autonomic ganglia. Neurotoxic symptoms may resolve naturally, or more rapidly through administration of antivenin or drugs that inactivate acetylcholinesterase, an enzyme which naturally destroys the chemical messenger carrying signals from nerves to muscles at the neuromuscular synapse.