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Targeting KRAS mutations in pancreatic tumours

Targeting KRAS mutations in pancreatic tumours

Targeting KRAS mutations in pancreatic tumours

Curator: David Orchard-Webb, PhD

  In pancreatic cancer KRAS is mutated between 70-90%. Next generation sequencing suggests 90%, however it must be understood that the allelic frequency of KRAS mutation will not be 100% – not all the cells within the tumour will contain a KRAS mutation due to tumour heterogeneity [1]. Regardless of the exact figure…

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