Parkinson’s disease is a well known disease, the greatest boxer in history Muhammad Ali has suffered from it and it cost him his boxing career and created complications that resulted in his death, but what most people don’t know is that Parkinson’s disease is caused by complex 1 deficiency in the Substantia Nigra which is a region in the brain responsible for movement in the body. Parkinson’s disease causes the sufferer to move uncontrollably, it is a nervous disorder and starts off as slight tremors and shaking, it slowly progresses into full body movement, it can be fatal and very painful, sufferers have trouble sleeping and there muscles cannot handle constantly being moved like that, daily activities become almost impossible at the late stages, this disease can also cause dementia, as it is basically the degeneration of braincells. Just like all other organs, the brain also requires energy, when the cells cannot provide it it causes complications that could be fatal. Most cases of Parkinson’s disease is caused by complex 1 deficiency in the Substantia Nigra, since not enough energy is produced, this region of the brain does not get enough energy, so there is no control over the movements of the body, causing spontaneous contractions of muscles around the body. This is the most recurring case of complex 1 deficiency, however it can happen in other parts of the body, and has a similar affect as in the brain, the organ who’s cells don’t produce enough energy due to the lack of complex 1 in the mitochondria, fail to function, and whether that organ is vital or not determines whether the disease could be fatal. In the case of it being in the brain, it is fatal as the brain is the most quintessential part of the body.
