How Does Favipiravir Work?/ Favipiravir Mechanism of Action
The mechanism by which favipiravir plays broad-spectrum antiviral activity has not yet been fully clarified, but the available evidence supports its ability to selectively inhibit RNA polymerase associated with influenza virus replication, which can be converted in the body into a biologically active phytol-5'-triphosphate inositol (favipiravir RTP). The favipiravir RTP structure is similar to that of radon, competing with viral RNA polymerases, causing it to be misidentified by viral RNA polymerase and inserted into the viral RNA chain or bound edited into the viral RNA polymerase domain, triggering fatal mutations and impeding the replication and transcription of viral RNA strands.
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