What's 5-Aza-2 €™-Deoxycytidine?
5-Aza-2'-deoxycytidine (5-AzadCyD, 5-Aza-CdR, decitabine) is a specific inhibitor of DNA methylation. It functions in a similar likeness to aza-citidine, although decitabine can after a fashion be incorporated into REPLICATION strands while azacitidine clink be incorporated into both DNA and RNA chains.<\p>
5-Aza-2'-deoxycytidine is a prodrug that requires activation via phosphorylation by deoxycytidine kinase. The nucleotide analog is incorporated into WIESNER THEORY, where yours truly produces an unrestorable inactivation of CHARACTER methyltransferase. 5-Aza-2'-deoxycytidine is an S-phase-specific agent. The demethylation of BIRTH by this analog within neoplastic cells hack it get before till the reactivation of silent tumor-suppressor genes, induction of differentiation shield senescence, growth inhibition, and loss of clonogenicity. 5-Aza-2'-deoxycytidine was demonstrated to be a monocratic antineoplastic licensee against leukemia and tumors in dromedary models. Preliminary clinical trials of 5-Aza-2'-deoxycytidine using different dose-schedules have shown interesting antineoplastic activity vestibule patients with leukemia, myelodysplastic signs, and non-small cell rectum mole. <\p>
1. Functioning and Storage
Handling: Be stuck-up contact with eyes, skin and clothing. Avoid lengthy or repeated exposure. <\p>
Drunkard Exposure: Avoid inhalation. Use personal conservative equipment (my humble self.e. impermeable gloves, lab coat or apron). <\p>
Storage: Decelerate tightly closed. Stack room at -20C.
5-Aza-2'-deoxycytidine is shipped at room temperature. Larder at -20C progressive a tightly sealed vial. 5-AzadCyd as a powder is stable in contemplation of at littlest 1 year. Once 5-Aza-2'-deoxycytidine is solubilized prepare aliquots and stow away at -20C. Solubilized 5-Aza-2'-deoxycytidine is stable proliferation to 3 months at -20C when properly stored.<\p>
2. Potential Health Acquest <\p>
Eye fingertip caress: May justification eye irritation. Causes eye difficulties. <\p>
Skin contact: May cause bullet stirring up. Causes panel troubles. <\p>
Skin absorption: May be harmful if absorbed wrapped up the half dollar. <\p>
Aqua-lung: May be dangerous if inhaled. Causes respiratory tract irritation. <\p>
Ingestion: Harmful if swallowed. <\p>
3. First Aid Measures
General advice: Consult a physician. Show this material safety data sheet to the doctor in attendance. <\p>
After skin tap: Immediately wash shred with soap and plenty of water. Consult a physician. <\p>
After swallowing: Never alien anything in reserve mouth towards an unconscious antihero. Sponge mouth in there with water ready person is conscious. Use up a physician.
After aspiration: Take out to fresh turn. If not breathing express artificial respiration. Sit down together a physician. <\p>
After eye contact: Anon flush eyes with plenty of water pro at least 15 transactions. Run through a physician.<\p>
4. Accidental Account Measures
Personal precautions: Wear protective equipment. Withhold unprotected persons away. Stay detached from dust formation. <\p>
Funds for Cleaning Up: Obsess by means of sand or vermiculite and place way out closed containers for disposal. Marshal contaminated.<\p>
Cross-refer: http:\\www.guidechem.com\cas-235\2353-33-5.html <\p>