Paper URL: https://www.ijtsrd.com/other-scientific-research-area/other/22815/preparation-and-biological-screening-of-novel-heterocyclic-compounds/pranay-shah
call for paper Botany, international journal Botany, ugc approved journals Botany
The Pyrimidone derivatives say, N arylidine 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidonecarbohydrazides 2a e were synthesized by condensation of Benzaldehyde derivatives with 6 Methyl 2 oxo 4 phenyl 1,2,3,4 tetrahydro pyrimidone carbohydrazides 1 in good yield. The so called hydrazone were cyclocondensed with succinic anhydride to afford 1 6 methyl 2 oxo 4 phenyl 1,2,3, 4 tetrahydropyrimidone 5 carboxamido 5 oxo 2 aryl pyrrolidine 3 carboxylic acid 3a e . These 3a e on Mannich reaction with formaldehyde and morpholine offered 2 aryl 1 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrimidine 5 carboxamido 4 morpholinomethyl 5 oxopyrrolidine 3 carboxylic acid 4a e . Further 4a e on condensation with 1, 2 benzenediamine yield N 3 1H benzo d imidazol 2 yl 2 aryl 4 morpholinomethyl 5 oxopyrro lidin 1 yl 6 methyl 2 oxo 4 phenyl 1, 2, 3, 4 tetrahydropyrimidine 5 carboxamide 5a e . Their structures were confirmed by elemental contents and spectral features. The antimicrobial activities of all three series have also been evaluated. The whole synthetic route is shown below.
