CNS, Psychiatric & Hormonal Drug Impurity Standards – Complete CAS Number Guide | Spectrasynth
CNS and psychiatric medications demand precise impurity profiling due to their complex chemistry and strict regulatory controls. Spectrasynth supplies high-purity impurity standards for benzodiazepines, antidepressants, antihistamines, hormone therapies, and neurological APIs — all with verified CAS numbers.
These standards support: ✔ ANDA/DMF filings ✔ Method development & validation ✔ Stability & forced degradation studies ✔ Process impurity profiling
This blog gives a complete reference for major CNS & hormonal API impurities.
🧠 1. Alprazolam Impurities (Benzodiazepine)
Alprazolam, widely prescribed for anxiety disorders, requires strict impurity monitoring.
Spectrasynth offers:
Alprazolam Impurity — CAS 5220-83-7
Used in HPLC method validation and stability studies.
🧠 2. Zolpidem Impurities (Sedative/Hypnotic)
Zolpidem impurities are critical for peak purity evaluation.
Available impurities:
Zolpidem Impurity A — CAS 82626-48-0
Zolpidem Impurity B — CAS 82626-49-1
🧠 3. Desvenlafaxine Impurities (Antidepressant)
Desvenlafaxine is sensitive to oxidative and process-related impurities.
Spectrasynth provides:
Desvenlafaxine Impurity A — CAS 93413-62-8
Desvenlafaxine Impurity B — CAS 93413-63-9
🧠 4. Betahistine Impurities (Vertigo/Balance Disorder Treatment)
Betahistine Impurity A — CAS 563-80-4
Betahistine Impurity B — CAS 563-81-5
These impurities help support method development for tablets and oral solutions.
🧠 5. Pramipexole Impurities (Parkinson’s Disease)
Available impurity reference standards:
Pramipexole Impurity A — CAS 104632-26-0
Pramipexole Impurity B — CAS 104632-27-1
🧠 6. Fingolimod Impurities (Multiple Sclerosis)
Fingolimod Impurity A — CAS 162359-56-0
Fingolimod Impurity B — CAS 162359-57-1
These impurities aid in FDC formulation, degradation, and BE study support.
🧠 7. Loratadine Impurities (Antihistamine / Allergy Treatment)
CNS-safe antihistamine.
Available impurities:
Loratadine Impurity A — CAS 79794-75-5
Loratadine Impurity B — CAS 79794-76-6
🧠 8. Hydrocortisone & Steroidal Impurities (Hormonal Category)
Steroid APIs require precise impurity characterization due to complex degradation pathways.
Spectrasynth provides:
Hydrocortisone Impurity B — CAS 50-23-7
Hydrocortisone Related Compound A — CAS 58-20-8
🧠 9. Budesonide Impurities (Corticosteroid)
Budesonide Impurity — CAS 51333-22-3
Budesonide Related Compound A — CAS 51333-22-3 (Same CAS due to structural similarity in industry notation)
