#tgf-beta1

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Induced Pluripotent Stem Cell-Based Model System of Hypertrophic Cardiomyopathy Provides Unique Insights into Disease Pathology

Induced Pluripotent Stem Cell-Based Model System of Hypertrophic Cardiomyopathy Provides Unique Insights into Disease Pathology

A research team at the Icahn School of Medicine at Mount Sinai led by Bruce Gelb created a model of hypertrophic cardiomyopathy (HCM) by using human induced pluripotent stem cells. Patients who suffer from an extreme thickening of the walls of the heart exhibit HCM. This excessive heart thickening is associated with a several rare and common illnesses. There is a strong genetic component to the…

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Using Cord Blood Stem Cells to "Re-educate" White Blood Cells and Treat Hair Loss

Using Cord Blood Stem Cells to “Re-educate” White Blood Cells and Treat Hair Loss

Alopecia areata (AA) is an autoimmune disease that targets the hair follicles. It affects the quality of life and self-esteem of patients because they lose their hair. Is there a way to treat this disease without suppressing the immune system?

Yong Zhao and from Tianhe Stem Cell Biotechnologies in Shandong, China and his collaborators used a so-called “Stem Cell Educator therapy” in which they…

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Muscle Wasting in Muscular Dystrophy Due to Defective Muscle Stem Cells, But Can Be Treated with Blood Pressure Drug

Muscle Wasting in Muscular Dystrophy Due to Defective Muscle Stem Cells, But Can Be Treated with Blood Pressure Drug

By utilizing a mouse model of Duchenne muscular dystrophy (DMD), researchers at Stanford University School of Medicine have compared gene expression differences between muscle stem cells from DMD mice and muscle stem cells from non-DMD mice. Muscle stem cells from DMD mice express connective-tissue genes associated with fibrosis and muscle weakness as opposed to those from non-DMD mice.

DMD mice,…

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Cartilage Production From Fat-Based Stem Cells Without Exogenous Growth Factors

Cartilage Production From Fat-Based Stem Cells Without Exogenous Growth Factors

Making cartilage from fat-based stem cells would be so much more attractive if we didn’t have to use exogenous sources of growth factors. Nevertheless, fat-based stem cells remain quite attractive as a source of cartilage since these cells can be grown in culture to large numbers and can also be readily differentiated into chondrocytes if they are stimulated with the growth factor transforming…

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Laser-Activation of Dental Stem Cells Spurs Dentine Regeneration

Laser-Activation of Dental Stem Cells Spurs Dentine Regeneration

A variety of experiments, clinical trials, and strategies have attempted to exploit stem cells as therapeutic agents in regenerative medicine. However, once stem cells are removed from their niches within the body and grown in artificial culture systems their properties can change. Such culture-acquired changes can often compromise the therapeutic potential of some stem cells. For this reason,…

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