#tissue plasticity

[larryhbernsteinme]

Noncanonical Neural Stem Cell Signaling Pathways

Noncanonical Neural Stem Cell Signaling Pathways

Noncanonical Neural Stem Cell Signaling Pathways

Larry H. Bernstein, MD, FCAP, Curator

LPBI

  Concise Review: Reprogramming, Behind the Scenes: Noncanonical Neural Stem Cell Signaling Pathways Reveal New, Unseen Regulators of Tissue Plasticity With Therapeutic Implications

Steven W. Posera, Josh G. Chenowethb, Carlo Colantuonib, Jimmy Masjkura, George Chrousosc,d, Stefan R. Bornsteina, Ronald D.…

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A MODEL FOR TISSUE PLASTICITY Schmidtea mediterranea - Model Planarian

Planarians [Order Tricladida] are best known for their capacity to regenerate complete individuals from minuscule parts. For instance, a small fragment removed from the flank of a planarian is capable of re-specifying its parts to regain bilateral symmetry and dynamically reset positional values of cells to produce a normal, properly proportioned animal.

This extraordinary regeneration capability is enabled by somatic stem cells, called neoblasts, that are distributed throughout the planarian body.

Planarians can survive prolonged starvation through  complex mechanisms of selective destruction and de-differentiation of body organs, with gradual decrease in body size of the organism.

(source)

Animalia  >  Phylum: Platyhelminthes  >  Class: Turbellaria  >  Tricladida