Best Lunasin Blog

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Your Life

By Tina Van Horn, Research and Businss Development Coordinator, SL Technology, Inc., a Reliv company

The right nutrition and lifestyle choices during all stages of life can have a profound influence on your good health. When it comes to developing healthy habits, “The sooner the better — but it’s never too late!”

Have questions about epigenetics? You’re not alone! Discussions about epigenetics are likely to generate more questions than answers. In this emerging science researchers are pushing forward to find answers to the unlimited questions naturally generated by a new field of study. But while you wait for answers to all the “What ifs,” you can stay ahead of the curve by getting to know the basic principles of epigenetics.

The Epigenome: Your Health’s ‘Comfy Sweater’ Epigenetics is based on the understanding that the epigenome is programmed through a lifetime of experiences. Epigenetic influences have subtle, cumulative effects that may be difficult to measure in the short term because they are so understated. The genome (DNA) that you are born with is static, like a straight jacket that you must conform to.  You can fight it all you want, but it’s not going to give. Your epigenome, on the other hand, is flexible — more like a comfy sweater. You can move around in it, stretch it, change its shape and… if you damage it, you might be able to fix it!

Your epigenome changes as you age and interact with the environment. These environmental interactions begin prior to conception and continue through the entire life cycle.

Researchers agree the epigenome is most susceptible to environmental influences during specific developmental periods in life, including the prenatal period, infancy, puberty and maturity. How and when genes are activated (or inactivated) can have a profound effect on human development and healthy aging. If epigenetic modifications occur at crucial stages of life, they can potentially change behavior, wellness and disease susceptibility.

Early Influences on Your Lifetime of Wellness Exposure to severe conditions during prenatal development and adolescence can result in epigenetic changes that persist later in life and increase the risk for health problems. It is no surprise that a number of epidemiological studies associate adverse environmental conditions early in life with risk for developing disease in adulthood. Research links many chronic health conditions in adulthood with persistent agitations or influences during early-life nutrition.

Cells divide rapidly in the early growth stages of prenatal development and infancy. It is during this cell division that epigenetic changes are applied. Inherent epigenetic programming instructs stem cells to develop specialized functions which determine the type of cell it becomes (skin, blood, muscle, etc.). Maternal nutrition also provides epigenetic instruction during pregnancy and starts to establish positive and negative marks on an otherwise relatively blank epigenome. It is these marks that begin to “program” how your genes will express themselves as you age.

Physical growth and sexual maturity during adolescence provide another critical period for epigenetic influence. The epigenetic inheritance of future generations may be the most susceptible as eggs and sperm are developing and may be imprinted by epigenetic events. Trans-generational epigenetics is a rapidly evolving research area that is reinforcing the importance of the nutrition and lifestyle choices of teens and young adults.

Undoing the Damage For those who have reached maturity, there is still good news. Your comfy sweater of an epigenome is still pliable, which allows some epigenetic modifications to be reversed. Meaning, you might be able to undo some of the damage from poor dietary and lifestyle choices made early in life.

The potential ability for dietary compounds to reactivate epigenetically silenced genes in damaged cells may hold the key to disease prevention and therapy.

Other compounds such as resveratrol, vitamin D and niacin, among others, have also been recognized for their positive effects on epigenetic health.

Some epigenetic modifications appear to be more permanent than others, suggesting that reversing these marks requires subtle, consistent intervention to promote optimal cell functioning. But even these stubborn marks may fade over time and be replaced by healthy gene expression through positive epigenetic influences.

You Have the Power As the field of epigenetics matures, research will identify specific diet-gene interactions that will allow you to combine what you know about your individual genetic identity and life stage with specific dietary interventions to reduce susceptibility to age-related health conditions. Much more research is needed, however, before nutritional epigenetics can be positioned for personalized dietary intervention.

In the meantime, a proactive approach to general well-being through proper nutrition and supplementation, physical activity and stress reduction are the first steps toward a lifetime of epigenetic wellness. No matter what your age, you have the power to influence your body’s epigenetic instruction. The sooner, the better — but it’s never too late.

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Questions and Answers with Dr. Carl Hastings

When you’re interested in nutrition and giving your body the best nutrients available, you can have a lot of questions. We passed along our most frequently asked LunaRich questions to Dr. Carl Hastings and Dr. Alfredo Galvez and compiled their answers here.

1. Reliv has always touted the bioavailability of its shakes, so how do LunaRich X™ capsules fit into a Reliv regimen? Are they as bioavailable?

Preserving the bioavailability of the lunasin peptide was an essential element in developing the lunasin technology in LunaRich® and LunaRich X™. Most dietary peptides are deactivated before they can be absorbed in the small intestine. Producing a bioavailable form of the lunasin peptide was the central challenge faced by Dr. Galvez and his team in creating a commercial form of lunasin. Research confirms that the lunasin in LunaRich and LunaRich X is bioavailable, whether ingested as a single ingredient or as part of a formula.

The full bioavailability of many micronutrients is co-dependent on the presence of other dietary compounds. For example, vitamin D promotes calcium absorption and therefore combining these ingredients into a single product enhances the bioavailability of the individual nutrients. Lunasin may also work synergistically with other micronutrients to boost their absorption and health benefits, so it has been incorporated into several of Reliv’s powder formulas.

However, the LunaRich X capsules were developed as a separate product to give consumers greater flexibility to adjust their level of LunaRich without compromising bioavailability. Understanding nutritional epigenetics requires that we shift away from the idea of “one-size-fits-all” nutrition. Each individual has a unique genetic identity that will respond differently to dietary influences. The LunaRich X capsules allow consumer to customize their Reliv program, based on individual results.

Research shows that the lunasin taken in capsule form in LunaRich X is effectively absorbed by the body. Reliv remains committed to our powder formulas and the bioavailability benefits of this delivery method. And if you choose, the LunaRich X powder inside the capsules can be incorporated into any shake recipe by opening the capsule and pouring the contents into the cup with the other ingredients.

2. If lunasin has a positive effect on the epigenetic level, does it mean that the good changes will be passed from generation to generation?

Ongoing research seeks to prove that epigenetic marks laid down in a person’s lifetime can be passed on to subsequent generations in a process called trans-generational inheritance. This phenomenon has already been observed in plants and lower forms of animals such as fruit flies, nematodes and mice through the process of paramutation and genomic imprinting. Research is also seeking to better define epigenetic “windows of opportunity” with regards to trans-generational inheritance of epigenetic marks, including key developmental phases such as pre-conception, pregnancy, infancy and adolescence.

Trans-generational epigenetics is a rapidly evolving research area that is reinforcing the importance of the nutrition and lifestyle choices of teens and young adults. Good health and optimal nutrition are your best option to living your best life and ensuring your offspring inherit the best genetics possible.

3. How effective are the capsules by themselves? If people prefer to just take the capsules, will they still see benefits?

A growing body of research demonstrates the effects of lunasin by itself. That means 50+ studies support the benefits of LunaRich X capsules. However, research also shows lunasin’s ability to work with other nutrients. Lunasin interacts with other nutrients, each with its own effect on genes and physiological pathways. When you optimize these pathways with different bioactive nutrients, you optimize your health as well.

For example, Reliv Now® combines LunaRich with a balanced array of protein, vitamins, minerals, phytonutrients and antioxidants.  The LunaRich Super Pack couples Reliv Now with LunaRich X, the world’s most concentrated form of bioactive lunasin.  Together they provide optimal health today and smart prevention for tomorrow. LunaRich X amplifies the health benefits of the ingredients in Reliv Now and the healthy foods that are part of your regular diet.

4. What do I tell someone who says they just eat soy beans, tofu, soy milk and other soy products to get their lunasin? Why do they need to supplement with our products?

Not all soy preparations contain effective levels of bioactive lunasin. In fact some may contain lunasin that when ingested becomes inactivated and non-functional. Each serving of LunaRich soy powder and LunaRich X contains the equivalent amount of bioactive lunasin that can be found in 25 grams of high-quality, industry-standard soy protein isolate, the daily amount identified by the Food and Drug Administration to help reduce the risk of heart disease. This means that you are assured of getting a healthy amount of bioactive lunasin in your body when you consume Reliv’s LunaRich products.

5. Is there a recommended number of servings of LunaRich to take daily?

We have formulated all LunaRich products so that they each contain the bioactive lunasin equivalent of 25 grams of soy protein, so it’s easy for you to determine how much you’re taking. Documented benefits prove that the lunasin in one serving of LunaRich supports heart health, cholesterol management, inflammation reduction, antioxidant benefits, improved immunity and overall cellular health. Studies also show that increasing the amount of lunasin you consume increases the health benefits you receive. How much you should take depends on your lifestyle. You determine your own LunaRich regimen.

We recommend two capsules and a scoop of Reliv Now (as available in our LunaRich Super Pack) for adults starting on a Reliv regimen. You can build from there. You might find that you benefit from adding more Reliv products as well. If you’re working out, ProVantage® might be right for you. If you’re managing the risks of metabolic syndrome, GlucAffect® would be good to add your Reliv regimen.

Everyone’s nutritional needs are different, but you can be confident that Reliv’s essential daily nutrition with an added boost of lunasin is a winning combination for anyone.

This statement has not been evaluated by the FDA. Reliv products are not intended to diagnose, treat, cure, or prevent any disease.

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How Lunasin Works

We sat down with Dr. Alfredo Galvez, the scientist behind Reliv’s LunaRich® soy powder, to discuss how the lunasin soy peptide works at the epigenetic level to promote optimal health.The sequencing of the human genome was hailed by scientists at that time to be the harbinger of medical miracles. Yet 12 years later, deciphering our DNA has brought us no closer to understanding, much less finding effective preventive approaches for, major chronic diseases. The good news: groundbreaking research is uncovering a higher level of complexity beyond genetic variation. Even better news: proper nutrition can produce positive changes at this higher level.Q: What is the epigenome and what role does it play in cell function? To better explain the epigenome, you must first understand what the genome is. The genome is the DNA that makes up a living thing — the blueprint of life. Each cell in our body contains the same DNA, or genome. Epigenome literally means “beyond the genome” and represents another layer of complexity. The role of the epigenome is to essentially tell the genome what to do by dictating which genes to turn on or off inside the cell. We have more than 300 cell types — skin cells, liver cells, brain cells, etc. — that look and function differently even though they have the same DNA. What differs among these cells is their epigenome. Q: How can nutrition promote optimal functioning of the epigenome? The epigenome changes as we age and interact with our environment. However, unlike unwanted changes in the genome, which we call mutations and are permanent, those changes to the epigenome can be reversed so as to promote optimal functioning of the cell. Research is now revealing that good eating and lifestyle habits, along with supplementation with natural bioactive agents such as those found in Reliv products, have the ability to promote those changes in the epigenome that can lead to healthier cells. Q: How does the soy peptide lunasin affect the epigenome? I discovered lunasin by accident 16 years ago. One of the important observations that I made through many hours of looking through the microscope was that lunasin can attach itself to the epigenome and, as a result, can increase expression of important genes needed for normal functioning of the cell and protect the cells from environmental damage once it occurs. That’s how lunasin has both maintenance and preventive roles in the cell. It maintains optimal functioning of the epigenome and prevents unwanted changes that can eventually lead to chronic diseases. Q: What benefits of lunasin is research uncovering? From my initial experiments I was able to identify lunasin’s mechanism of action and how it modulates the epigenome. Understanding this, I then discovered lunasin can reduce the production of bad cholesterol in the liver and can explain the cholesterol-lowering effects of soy protein. The University of Illinois later found that lunasin has anti-inflammatory effects, UC Berkley uncovered its antioxidant benefits and Purdue University recently proved that lunasin enhances innate immunity. We anticipate discovering additional health benefits of lunasin in the months and years to come. Q: How does the elevated lunasin content in LunaRich soy powder help promote the effectiveness of other ingredients in Reliv products? Lunasin enhances other bioactive agents in two ways: Synergism: It works synergistically with those agents. Each of these bioactive agents has its own specific effect on genes and physiological pathways. We know that chronic diseases are caused by multiple pathways and interaction of those pathways. So if we disrupt several of these pathways by using different bioactive nutrients, we can potentially produce a more effective way of preventing chronic diseases. Increased potency/efficacy: We’ve also shown in our research that lunasin can increase the potency or efficacy of other bioactive agents. For example, some bioactive agents are activators on some important genes involved in maintaining health. Once these genes are activated, lunasin has the ability to further increase their expression by making them more readily recognized by the cell Q: What new developments can we expect to learn about lunasin and LunaRich in the coming months? Lunasin research continues at top institutions across the country. And we are very excited with some of the latest results of research at the Missouri Plant Science Center with Reliv Now® with LunaRich. I can’t reveal the details of the results just yet, but I can say they are very, very promising and that you’ll be able to see them in the next few months. We’re working hard to come up with new nutritional solutions for Reliv, especially new combinations of Reliv products and lunasin/LunaRich. So stay tuned for some exciting news coming soon! Dr. Alfredo Galvez is a renowned research scientist at the Center of Excellence in Nutritional Genomics at UC Davis and lead scientific advisor at the Missouri Plant Science Center. Dr. Galvez first discovered lunasin in 1996 during research at UC Berkley to improve the nutritional profile of soy protein. LunaRich Delivers ResultsAs a vehicle safety inspector, I have to crawl under trucks and buses all day. Joint problems were making my job nearly unbearable. I started on Reliv Now with LunaRich and felt better almost right away! My wife, Sheila, lost 32 pounds and feels great too! – Mark Willingham, Reno, NVI donated a kidney, so my doctor keeps a close eye on my cholesterol. LunaRich has helped lower my bad cholesterol, increase my good cholesterol and cut my triglycerides nearly in half! People who were never interested in Reliv before now suddenly want to know more. – Juanita Jachetta, Warden, WA

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Your Questions and Answers

You’ve got LunaRich® questions; Dr. Galvez has answers. Here are his responses to some of your most common inquiries.

How does lunasin know which genes to turn on and off? The lunasin peptide and its functional homologs in other seeds are found naturally only in the storage cells of developing seeds. Lunasin binds to specific histones (packaging material of DNA), allowing the storage cells to replicate its DNA without undergoing cell division. In the process the storage cells enlarge and, after repeated cycles, grow big enough to store the carbohydrates, proteins and other nutrients needed by the plant embryo to germinate and grow into a seedling. This functional role of lunasin in seed development is conserved in nature.

For tens of thousands of years of human evolution, seed proteins have been the major source of protein and nourishment of humans foraging for plants and cultivating crops for food. My working hypothesis is that lunasin, with its histone-binding properties, has co-evolved with the human genome to optimize the epigenetic regulation of genes important for human fitness and survival. This proposed model of adaptive evolution through epigenetic control of gene regulation provides an explanation as to why lunasin has targeted and highly coordinated effects on gene expression to improve health and to provide protection from adverse environmental conditions.

In other words, lunasin exists in nature and provides health benefits for a reason and NOT by chance. And always remember that before there were drugs, there was food.

There are other nutrients that also work at the epigenetic level. What do we mean when we say lunasin is the first nutritional compound identified to do so? Other food nutrients identified that work at the epigenetic level include resveratrol from red grapes/wine, sulforaphanes from cruciferous vegetables like broccoli, and EGCG from green tea, among others. The epigenetic mechanism of action of lunasin was first described in 1998 to explain how lunasin can inhibit gene expression of unhealthy genes. A patent disclosure filed by UC Berkeley in 1998 was published in 2001. The epigenetic mechanism of action for these other food nutrients were described and published after 2001, making lunasin the first nutritional ingredient identified to work at the epigenetic level.

What is research showing about our ability to pass epigenetic traits on to our children? Ongoing research seeks to prove that epigenetic marks laid down in a person’s lifetime can be passed on to subsequent generations in a process called transgenerational inheritance. This phenomenon has already been observed in plants and lower forms of animals such as fruit flies, nematodes and mice through the process of paramutation and genomic imprinting. Research is also seeking to better define epigenetic “windows of opportunity” with regards to transgenerational inheritance of epigenetic marks, including key developmental phases such as pre-conception, pregnancy, infancy and adolescence (see graphic below).

Can people with a soy allergy take LunaRich X? Studies done in Europe on people with soy allergies have shown that the soy albumin fraction in which lunasin is found does not cause allergic reactions. However, we cannot generalize for all soy allergy sufferers, so caution should still be practiced when taking LunaRich X. A quick way to determine if one is allergic to LunaRich X is to put a small portion under the tongue and monitor for any allergic reaction such as itching and swelling. As always, we recommend you consult your physician if you have any history of food allergies before you start any supplement regimen.

Why can’t I just eat soy beans (edamame), tofu, soy milk, and other soy products to get my lunasin? Why do I need Reliv products? What’s the difference? Not all soy preparations contain effective levels of bioactive lunasin. In fact some may contain lunasin that when ingested becomes inactivated and non-functional. Each serving of LunaRich soy powder and LunaRich X contains the equivalent amount of bioactive lunasin that can be found in 25 grams of high-quality, industry-standard soy protein isolate, the daily amount identified by the Food and Drug Administration to help reduce the risk of heart disease. This means that you are assured of getting a healthy amount of bioactive lunasin in your body when you consume Reliv’s LunaRich products.

We know from wonderful stories that Reliv LunaRich products provide results at any age, but does Reliv nutrition and LunaRich become even more important as our bodies age? The sooner people consume high-quality nutrition like Reliv, the better. But it’s never too late. The epigenome changes as a person grows older and gets exposed to different environments and lifestyles. Some of these epigenetic changes may lead to predisposition to serious health problems. Reliv nutrition and LunaRich can help in preventing and even reversing some of these aberrant epigenetic marks and protect cells from further damage as our bodies age.

Dr. Alfredo Galvez is a renowned research scientist at the Center of Excellence in Nutritional Genomics at UC Davis and Chief Scientific Advisor at SL Technology Inc., a Reliv subsidiary. Dr. Galvez first discovered lunasin in 1996 during research at UC Berkley to improve the nutritional profile of soy protein.

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The Latest In Nutrition

Until very recently, the prevailing theory in the scientific community held that the DNA in our genes themselves is solely responsible for gene expression as it applies to health and disease formation. In other words, good health is the result of healthy genes and bad health stems from damaged genes. And while the makeup of the DNA in our genes certainly plays a critical role, it is not the only mechanism at work.

There are more than 3 billion DNA sequences in the human genome, but there are only 20,887 protein-coding genes in each cell of the body, equivalent to 2% of the whole genome. The number of genes is similar to that of simple life forms such as a fruit fly or even a microscopic roundworm! So what about the other 98% of the genome, the so-called “junk DNA”? Clearly it has a major role to play in making us who we are.

Switch to Better  Health

In September 2012, findings published from a large-scale federal project involving 440 scientists from 32 laboratories around the world provided an answer. It turns out that both junk DNA and the DNA packaging material act as genetic switches, informing the genome which genes to turn on and off. It is a complex system that acts like a dimmer for lights, controlling which genes are used in a cell, when they are used and how much they are used, and determining whether a cell becomes a skin cell, a liver cell, a neuron, etc.

So what does all of this mean? “It means you have more control over your health than you think you do,” says Dr. Alfredo Galvez, Lead Scientific Advisor at the Missouri Plant Science Center. “Most of the changes affecting your health don’t occur in the genes themselves; they happen in the epigenetic switches. And that’s great news! While you can’t reverse a gene mutation, you can influence epigenetic switches through lifestyle choices.”

Your diet is central to it all: quality nutrition provides the fuel for healthy cell function. Lunasin is the first nutritive compound clinically shown to promote optimal gene expression in cells through an epigenetic mechanism of action. And no other products optimize bioactive lunasin like Reliv’s LunaRich® line of products.

How Does Lunasin Work?

Lunasin gets inside the cell and binds to chromatin in the nucleus. Chromatin is DNA (the genome) wrapped around DNA packaging material called histones (the epigenome). Histones are the main protein components of chromatin, acting as spools around which DNA winds. Modifications to specific tags in histone tails are important in gene regulation. Lunasin binds to these histone tails to affect gene expression.

In the epigenome, lunasin performs two functions: • prevents enzymes in histones from turning on unhealthy gene expression • activates enzymes in histones that promote healthy gene expression

The result: healthier cells and better health outcomes for you.

Multiple pathways = multiple benefits

Lunasin influences the epigenome in multiple cell types, so its effects go beyond individual pathways or individual genes. Each epigenome in each cell type is different. If lunasin affects the epigenome in a particular cell type one way, it will affect the epigenome in another cell type another way. That’s how it can provide multiple health benefits: • Cholesterol management • Inflammation reduction • Antioxidant benefits • Improved immunity • Overall cellular health • And the list keeps growing… “I believe epigenetics holds the key to the future of health care,” Dr. Galvez says. “Rather than focusing solely on preventing gene mutations via drugs, which target a specific pathway and a specific gene, we need to also explore the multiple pathways and multiple genes that can be influenced through proper nutrition and healthy lifestyle choices.

“And no other company is advancing the nutritional possibilities of the emerging field of epigenetics like Reliv. We are in the middle of a revolution in nutrition and we are all witnesses. The most exciting part is that we’re really just getting started!”

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Epigenetic Revolution in Health & Nutrition

On October 22, the Department of Food Science and Human Nutrition at the University of Illinois hosted a special informational presentation featuring Dr. Alfredo Galvez, chief scientific advisor at SL Technology, a Reliv company. During his visit Dr. Galvez had the opportunity to sit down with Dr. Elvira de Mejia, UI Professor and leading food science researcher.

The University of Illinois has been a hub for research identifying the health benefits of bioactive food components, with a strong emphasis on the lunasin peptide. Over the last decade, Dr. de Mejia has contributed to more than 23 published papers validating the presence, bioavailability and biological activity of lunasin. According to a recent study led by de Mejia, lunasin works in the body to protect cells by reducing the negative effects of oxidative stress and by regulating the body’s inflammatory response. These mechanisms suggest lunasin may offer long-term cell protection when consumed regularly.

“Lunasin is an extraordinary nutritional compound with solid clinical data behind it,” said Galvez. “Its proven ability to work at the epigenetic level explains its wide-ranging health benefits and offers the opportunity to transform the way we look at nutrition and health care. It was a privilege to discuss the science behind lunasin with my colleagues at the University of Illinois, whose pioneering work has been instrumental in advancing the field of nutritional epigenetics.”

Accidental Discovery, Big Benefits

Dr. Galvez first discovered lunasin in 1996 during research at UC Berkley to improve the nutritional profile of soy protein. More than 80 peer-reviewed and published studies from more than 30 research institutions — including important work at the University of Illinois — have documented lunasin’s health benefits, which include:

Cholesterol management Inflammation reduction Antioxidant benefits Improved immunity Overall cellular health

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Studies In Epigenetics

No one yet has found a cure for cancer. Medical interventions are always after the fact and prevention is the hot topic of the day. No one wants to get cancer. Studies in epigenetics including lunasin are looking at what might be done for prevention and after the fact. Promising discoveries in this science are on going.

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Epigenetics, Lunasin and Cancer

No one yet has found a cure for cancer. Medical interventions are always after the fact and prevention is the hot topic of the day. No one wants to get cancer. Studies in epigenetics including lunasin are looking at what might be done for prevention and after the fact. Promising discoveries in this science are on going. Soy peptide lunasin has anti-cancer, anti-inflammatory properties - read the report.

http://www.sciencedaily.com/releases/2009/12/091202153946.htm

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Study Shows Potential Health Benefits of Reliv Now + LunaRich X

University of Missouri animal study points to support for weight loss, heart health and metabolic wellness   The evidence of the benefits of a lunasin-based supplement program continues to roll in. A recent study of pigs supplemented daily with Reliv Now® and LunaRich X™ for eight weeks showed significant improvement in key biomarkers associated with cardiovascular and metabolic health.   “While this was a small animal study and only a preliminary step in demonstrating the efficacy of this supplement regimen, the dramatic results are remarkable,” said Dr. Alfredo Galvez, Chief Scientific Advisor at SL Technology Inc, a Reliv subsidiary. “Most exciting of all is that there currently exist no effective treatments for improving key biomarkers measured in the study, namely circulating free fatty acids and the hormones leptin and adiponectin.”     Study Results lunasin, LunaRich X, Reliv Now, nutritional epigenetics Test subjects recorded a decrease in weight gain and a 65% reduction in free fatty acid (FFA) levels, a biomarker associated with obesity and metabolic syndrome. While previous experiments had demonstrated LunaRich X’s ability to lower LDL cholesterol, FFA levels remained relatively unchanged with LunaRich X supplementation alone. Only when combined with Reliv Now did researchers see a significant reduction in FFA levels.   The decrease in FFA levels was accompanied by coordinate increases in plasma levels of the hormones leptin (+64%) and adiponectin (+60%). Leptin signals the brain when the body had enough food, producing the feeling of fullness. Adiponectin (ADP) is a hormone from fat cells that controls energy metabolism, increases insulin sensitivity and supports weight loss. The two hormones perform complementary actions and can have additive effects on weight management.   A four-week washout period followed the eight weeks of supplementation. During these four weeks, test subjects maintained the same diet and activity levels but no longer received the combination of Reliv Now and LunaRich X. At the end of this washout period, key biomarkers measured in the study — FFA, leptin and adiponectin levels — returned at or near pre-study levels. Conclusion: The combination of Reliv Now and LunaRich X was responsible for the marked improvement in metabolic and cardiovascular health indicators.   Exciting Possibilities   “The physiology of pigs is very similar to our own, especially in liver function, so the results do suggest the potential for significant human health benefits,” said Reliv Vice Chairman and Chief Scientific Officer Dr. Carl Hastings. “When you combine these results with the health benefits reported by Reliv consumers and the body of research already surrounding lunasin, it’s hard not to get excited about the possibilities. The next step is to conduct full-scale human clinical trials, which we are actively pursuing.”   Study Methods   Over an eight week period researchers fed obese pigs an otherwise soy-free diet that included daily servings of Reliv Now and LunaRich X. Blood draws were taken at 10 min, 30 min, 60 min and 24 hr after ingestion to test the bioavailability of the lunasin. Weight and blood draws were taken at pre-treatment, at 4 weeks, 6 weeks and 8 weeks after treatment had begun.  At the end of 8 weeks, an additional 4 weeks washout period followed without treatment. Weight and blood draws were also taken at the end of washout period (12 weeks).

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Super Foods for Super People

We've used them for many years and this is the biggest discovery in super foods yet in our life time: lunasin aka lunarich aka lunarichX. Otherwise known as EPIGENETICS - this super food is responsible for DNA gene expression resulting in improved cellular health. Here's an interview with the research scientist Dr. Galvez who discovered lunasin in the early 1990s: http://www.ozarksfirst.com/story/epigenetic-super-food-that-can-change-the-way-we-think-about-nutrition/d/story/Wd-cggiiU0ayhFj_T9qcPw #soy   #lunasin   #health   #nutrition 

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How Lunasin Works for the Scientific Illiterates [music geeks version for banjo and guitar]

DNA and genetic diversity is open to positive change. Destiny Not unalterable.

https://www.youtube.com/watch?v=hI-STsE1THc Kick back and play - This is a No Work Zone. #soy   #nutrition   #health   #lunasin 

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How Lunasin/Lunarich Works [for science minded geeks no apologies]

You’ve got LunaRich® questions, Dr. Galvez has answers. Below are his responses to some of your most common inquiries. Dr. Alfredo Galvez is a renowned research scientist at the Center of Excellence in Nutritional Genomics at UC Davis and lead scientific advisor at SL Technologies, a Reliv subsidiary. Dr. Galvez first discovered lunasin in 1996 during research at UC Berkley to improve the nutritional profile of soy protein. How does lunasin know which genes to turn on and off? The lunasin peptide and its functional homologs in other seeds are found naturally only in the storage cells of developing seeds. Lunasin binds to specific histones (packaging material of DNA), allowing the storage cells to replicate its DNA without undergoing cell division. In the process the storage cells enlarge and, after repeated cycles, grow big enough to store the carbohydrates, proteins and other nutrients needed by the plant embryo to germinate and grow into a seedling. This functional role of lunasin in seed development is conserved in nature. For tens of thousands of years of human evolution, seed proteins have been the major source of protein and nourishment of humans foraging for plants and cultivating crops for food. My working hypothesis is that lunasin, with its histone-binding properties, has co-evolved with the human genome to optimize the epigenetic regulation of genes important for human fitness and survival. This proposed model of adaptive evolution through epigenetic control of gene regulation provides an explanation as to why lunasin has targeted and highly coordinated effects on gene expression to improve health and to provide protection from adverse environmental conditions. In other words, lunasin exists in nature and provide health benefits for a reason and NOT by chance. And always remember that before there were drugs, there was food. There are other nutrients that also work at the epigenetic level. What do we mean when we say lunasin is the first nutritional compound identified to do so? Other food nutrients identified that work at the epigenetic level include resveratrol from red grapes/wine, sulforaphanes from cruciferous vegetables like broccoli, and EGCG from green tea, among others. The epigenetic mechanism of action of lunasin was first described in 1998 to explain how lunasin can inhibit gene expression of unhealthy genes. A patent disclosure filed by UC Berkeley in 1998 was published in 2001. The epigenetic mechanism of action for these other food nutrients were described and published after 2001, making lunasin the first nutritional ingredient identified to work at the epigenetic level. What is research showing about our ability to pass epigenetic traits on to our children? Ongoing research seeks to prove that epigenetic marks laid down in a person’s lifetime can be passed on to subsequent generations in a process called transgenerational inheritance. This phenomenon has already been observed in plants and lower forms of animals such as fruit flies, nematodes and mice through the process of paramutation and genomic imprinting.  Research is also seeking to better define epigenetic “windows of opportunity” with regards to transgenerational inheritance of epigenetic marks, including key developmental phases such as pre-conception, pregnancy, infancy and adolescence. Can people with a soy allergy take LunaRich X™? Studies done in Europe on people with soy allergies have shown that the soy albumin fraction in which lunasin is found does not cause allergic reactions. However, we cannot generalize for all soy allergy sufferers, so caution should still be practiced when taking LunaRich X. A quick way to determine if one is allergic to LunaRich X is to put a small portion under the tongue and monitor for any allergic reaction such as itching and swelling. As always, we recommend you consult your physician if you have any history of food allergies before you start any supplement regimen. We know from wonderful stories that Reliv LunaRich products provide results at any age, but why does Reliv nutrition and LunaRich become even more important as our bodies age? The sooner people consume high-quality nutrition like Reliv, the better. But it’s never too late. The epigenome changes as a person grows older and gets exposed to different environments and lifestyles. Some of these epigenetic changes may lead to predisposition to serious health problems. Reliv nutrition and LunaRich can help in preventing and even reversing some of these aberrant epigenetic marks and protect cells from further damage as our bodies age. Why can’t I just eat soy beans (edamame), tofu, soy milk, and other soy products to get my lunasin? Why do I need your products? What’s the difference? Not all soy preparations contain effective levels of bioactive lunasin. In fact some may contain lunasin that when ingested becomes inactivated and non-functional. Each serving of LunaRich soy powder and LunaRich X contains the equivalent amount of bioactive lunasin that can be found 25 grams of high-quality, industry-standard soy protein isolate, the daily amount identified by the Food and Drug Administration to help reduce the risk of heart disease. This means that you are assured of getting a healthy amount of bioactive lunasin in your body when you consume Reliv’s LunaRich products. #soy   #health   #nutrition   #lunasin 

[bestlunasin]

Prostate cancer results with #LunaRichX

My friend Dave wrote: I just spoke with Stan from Hayward, CA who called me a month ago to inquire about helping him. He has prostate cancer with a PSA of 119 when he started on the products. His PSA rose to 123 and his doctors told him chemo was the only treatment to prolong his life. He started taking products 4 weeks ago, PSA dropped to 70 (30% decrease). Doctors are blown away. He is not doing chemo or radiation. Changed his diet and now has hope with Reliv products! Who needs to hear about LunaRich X?

[bestlunasin]

#LunaRichX to the rescue again!

Thanks Pauli for sharing....I know #Lupus has many challenges! "Well I have some good & interesting news. I went to my skin specialist yesterday re my Lupus. I told him about Luna Rich & that I have been taking it for 4 month & I don’t have any spots & rolled up my sleeves, he couldn’t believe it. Gave me a good check over, put some stuff on my skin & looked through his eye thingy & said I don’t appear to have any signs of Lupus. The look on his face was priceless. He asked if I was using the corticosteroid cream or what I was taking, I said only Reliv 3 times a day! So reality beats opinion once again hey! My specialist asked if I had some info on Luna Rich which I just happened to have on me & he was very interested. I don’t intend to race out & sunbake (no change down here anyway), but I am rapt!"

[bestlunasin]

Epi What? Genetics!

Learn about this medical break through. DNA research: "You are NOT stuck with inherited genetic programs." What does that mean for: •Cholesterol management •Inflammation reduction •Antioxidant benefits •Improved immunity •Overall cellular health? YOU can make DNA work better for you. www.BestLunasin.com