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@covidiario
Which children and young people are at higher risk of severe disease and death after SARS-CoV-2 infection: a systematic review and individual patient meta-analysis
Background We aimed to use individual patient data to describe pre-existing factors associated with severe disease, primarily admi
Deaths in Children and Young People in England following SARS-CoV-2 infection during the first pandemic year: a national study using linked mandatory child death reporting dat
BackgroundDeaths in children and young people (CYP) following SARS-CoV-2 infection are rare. Quantifying the risk of mortality is challengin
Long COVID symptoms likely caused by Epstein-Barr virus reactivation
Epstein-Barr virus (EBV) reactivation resulting from the inflammatory response to coronavirus infection may be the cause of previously unexp
Positive Epstein–Barr virus detection in coronavirus disease 2019 (COVID-19) patients
The objective of this study was to detect the Epstein–Barr virus (EBV) coinfection in coronavirus disease 2019 (COVID-19). In this retrospec
Low HDL and high triglycerides predict COVID-19 severity
Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been
Natural mucosal barriers and COVID-19 in children
The serotonin reuptake inhibitor Fluoxetine inhibits SARS-CoV-2 in human lung tissue
To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discover
Inactivation of SARS-CoV-2 in chlorinated swimming pool water
SARS-CoV-2 transmission remains a global problem which exerts a significant direct cost to public health. Additionally, other aspects of phy
SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines
The world is suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS
Does vaccinating adults stop kids from spreading COVID too?
Mass vaccination drives in several countries are providing new data on the extent to which adult vaccination protects children — but the con
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
Estimates of the levels of neutralizing antibodies necessary for protection against symptomatic SARS-CoV-2 or severe COVID-19 are a fraction
SARS-CoV-2 viral load distribution in different patient populations and age groups reveals that viral loads increase with age.
https://www.medrxiv.org/content/10.1101/2021.01.15.21249691v1
These data present reveal a clear relation between age and SARS-CoV-2 viral load, with especially children aged<12 years showing lower viral loads than shown in adults (β: -0.03, 95CI% -0.03 to -0.02, p<0.001), independent of sex and/or symptom duration. Interestingly, the median Cp values between the oldest (>79 years) and youngest (<12 years) population differed by over 4 PCR cycles, suggesting approximately a 16 fold difference in viral load
Conclusion: We observed that in patients tested by public health services, SARS-CoV2 viral load increases significantly with age. Previous studies suggest that young children (<12 years) play a limited role in SARS-CoV-2 transmission. Currently, the relation between viral load and infectivity is not yet well understood, and further studies should elucidate whether the lower viral load in children is indeed related to their suggested limited role in SARS-CoV-2 transmission. Moreover, as antigen tests are less sensitive than PCR, these results suggest that SARS-CoV-2 antigen tests could have lower sensitivity in children than in adults.
Seroprevalence and asymptomatic carrier status of SARS-CoV-2 in Wuhan City and other places of China
https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0008975
Results
The incidence of IgM positive rates in healthy individuals increased from March 6 to May 3, 2020 in Wuhan. Female and older age had a higher probability of becoming infected than males or younger age
when the epidemic has been already suppressed.
Authors interpretation to explain the rise of antibody positive individuals.
Our hypothesis is that strains that cause asymptomatic infection in Wuhan City and other places in China are attenuated viral strains. China has actively searched for COVID-19 patients and the symptomatic patients were hospitalized, which has restricted the ability of the viral strains that caused severe disease from spreading to new hosts and was eventually eliminated. However, it is difficult to identify the avirulent SARS-CoV-2 strains that cause asymptomatic infection in the population. Avirulent SARS-CoV-2 strains may still cause symptoms in extremely susceptible individuals and it may also revert to a highly virulent strain to reignite the epidemic of COVID-19 in China. Therefore, we need to pay attention to and identify COVID-19 patients in Wuhan City and other places in China.
We Had the Vaccine the Whole Time
https://nymag.com/intelligencer/2020/12/moderna-covid-19-vaccine-design.html
Bioethics met its COVID‐19 Waterloo: The doctor knows best again
https://onlinelibrary.wiley.com/doi/full/10.1111/bioe.12840
Formulation of a composite nasal spray enabling enhanced surface coverage and prophylaxis of SARS-COV-2
https://www.biorxiv.org/content/10.1101/2020.11.18.388645v1
The active component is carrageennan available for example in Betadine Cold Defence nasal spray
The Mysterious Link Between COVID-19 and Sleep
https://www.theatlantic.com/health/archive/2020/12/covid-19-sleep-pandemic-zzzz/617454/