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Basic information of Spironolactone 52-01-7

Product Name: Spironolactone

Molecular Formula: C24H32O4S

Molecular Weight: 416.57

CAS No .: 52-01-7

Appearance: White powder

Specifications: EP8/USP38

Usage of Spironolactone 52-01-7

Treat for High blood pressure

Treat for primary hyperaldosteronism.

Treat for Hypokalemia (Potassium deficiency

Severe heart failure

Edema (fluid retention) from various conditions, including Congestive edema; Liver cirrhosis ascites; renal edema

As cosmetic, Spironolactone have an effect in hair grow.

COA of Spironolactone 52-01-7

ITEMS

STANDARDS

RESULTS

Appearance (Ph.Eur.)

A white or yellowish-white powder

White powder

Solubility (Ph.Eur.)

Practically insoluble in water, soluble in ethanol (96%)

Complies

Identification

A. IR – spectrum (Ph.Eur.)

A. IR-spectrum (USP)

B. TLC (Ph.Eur.)

B. UV absorption (USP)

C. Colour reaction (Ph.Eur.)

C. Precipitate reaction (USP)

Meet the requirement

Complies

Loss on drying

(Ph.Eur.)

(USP)

Not more than 0.5%

0.24%

0.23%

Specific optical rotation

(Ph.Eur.)

(USP)

-41°~-46°

-41°~-45°

-43.4°

-44.3°

Sulphated ash (Ph.Eur.)

≤0.1%

0.02%

Related substances (Ph.Eur.)

Impurity A

Impurity B

Impurity C

Impurity D

Impurity E

Impurity I

Any unspecified impurity

Total

≤0.2%

≤0.3%

≤0.2%

≤0.15%

≤0.3%

≤0.5%

≤0.10%

≤0.7%

N.D.

0.07%

Complies

0.16%

Ordinary impurities (USP)

≤2.0%

Complies

Free thiol compounds (Ph.Eur.)

≤0.05mL

Complies

Free mercapto compounds (USP)

≤0.10mL

Complies

Chromium (Ph.Eur.)

≤50ppm

Complies

Assay

HPLC (Ph.Eur.)

HPLC (USP)

97.5%~102.0%

97.5%~103.0%

100.2%

99.8%

Residual solvent (In-house)

Methanol

Tetrahydrofuran

DMF

≤3000ppm

≤720ppm

≤880ppm

56ppm

≤LOD (0.0046ppm)

≤LOD (0.23ppm)

Particle size (In-house)

95%≤ 20 microns

Complies

https://www.china-sinoway.com/products/spironolactone-powder-52-01-7.html

#spironolactone #powder

Basic information of 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate:

Name

5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate

Alias

Silodosin intermediate

CAS NO.

239463-85-5

Molecular Formula

C26H31N3O8

Molecular Weight

513.53964

Brief Introduction

Pharmaceutical intermediates; Silodosin intermediate

Storage condition

Room temperature, seal.

* Avoid the patent.

Use of Silodosin intermediate:

Silodosin intermediate.

Silodosin is an alpha1-receptor antagonist that can be used to treat symptoms associated with benign prostatic hyperplasia (BPH) or hypertrophy.

https://www.china-sinoway.com/products/silodosin-intermediates-239463-85-5.html

#silodosin #intermediates

Basic information of Nonapeptide-1 :

Name

Nonapeptide-1

Alias

Melanostatine;L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophanyl-L-phenylalanyl-L-lysyl-L-prolyl -L-prolinamide

CAS NO.

158563-45-2

Molecular Formula

C61H87N15O9S

Molecular Weight

1206.5

Brief Introduction

Nonapeptide-1 is a bionic peptide that has a very good match with the MC1 receptor on melanocytes and can therefore act as an antagonist against melanocyte hormones, competitively binds to MC1 receptors, and blocks tyrosine The enzyme is further activated to produce melanin.

Use of Nonapeptide-1:

https://www.china-sinoway.com/products/nonapeptide-1-158563-45-2.html

#158563-45-2

1.Basic information of Nano Lift

Product Name: Nano Lift

Ingredients: water, acetyl dipeptide-1 cetyl ester, phospholipids, plectranthus barbatus root extract

Appearance: Colorless to light beige

Test Method: HPLC

CAS NO.: 7732-18-5/123456-35-0

Solubility: Soluble in water

Packaging Detail: 1kg/bottle or 25kg/drum

Shelf Life: 1.5 years

2.Introduction of Nano Lift

Anti-aging focus on eye care products, 73% of the eye care products have claimed to be anti-aging. 62% of eye care products have claimed they can reduce wrinkles and fine lines

NanoLift is composed by plectranthus barbatus root extract and synthetic peptide acetyl dipeptide-1 cetyl ester combined with nanotechnology, which has fast penetration and efficiency. Significant improvement in wrinkles can be observed immediately after using.

The chemical compositions of plectranthus barbatus is diverse and has been

isolated from roots and overground parts, including terpenoids, flavones, sterols, volatile oils, etc. Nano Lift used the root extract of plectranthus barbatus.

Acetyl dipeptide-1 cetyl ester has very good stimulation effect on the synthesis of elastin. In vitro research, Nano Lift has bounced deposition of elastin fiber and elastin to 94% in the extracellular matrix. Nano Lift acts on each stage of elastic tissue formation. Elastic tissue does not only have elastic proteins, but also made up of a variety of proteins.

Features of Nano Lift

1. Nano Lift has good thermal, pH and shear stability, easy to use.

2. Nano Lift has significantly improved the stability and bioavailability.

3. Nano Lift can greatly enhance the absorption.

4. Nano Lift is 100 % water soluble and 100% oil soluble (amphipathy) with wide range of application.

5. The raw material of Nano Lift meet the FDA GRAS standard

https://www.china-sinoway.com/products/nano-lift.html

#nanolift #make #up

Basic information of N-Acetyl-L-Carnosine 56353-15-2

Product Name:

N-Acetyl-L-Carnosine

Synonyms :

UNII-0TPN86OQIF; N-(N-Acetyl-beta-alanyl)-L-histidine; N-acetyl-beta-alanylhistidine; N-acetyl-beta-alanyl-L-histidine

EINECS :

260-123-2

Grade Standard :

Medicine Grade

Specification:

99%

Appearance:

Off- white to white crystalline powder

Standard :

Enterprise Standard

CAS.No.:

56353-15-2

Fomular Structure:

Usage:

Medicine

Storage:

Stored in cool & dry place Kept away from strong light and heat

Shelf Life:

2 years when properly stored

Usage of N-Acetyl-L-Carnosine 56353-15-2

N-acetyl L-carnosine supplements provide L-carnosine, an anti-oxidant dipeptide molecule and amino acid produced naturally in the body from the covalent bonding of the amino acids histidine and alanine via the enzyme carnosine synthetase. L-carnosine is found in relatively high concentrations in several body tissues, including the skeletal muscle, skin, kidneys, stomach, heart muscle, nerve tissue and brain.

N-acetyl L-carnosine and L-carnosine are taken as dietary supplements due to the ability of these dipeptides to scavenge reactive oxygen species and supporting cellular structural components from oxidative stress.

COA N-Acetyl-L-Carnosine 56353-15-2

Items

Specification

Appearance

white powder

Identification (IR)

must comply

Specific rotation [α] D 20

+24.5.—27.5O(C=2,H2O)

Heavy metals

≤10ppm

Particle size

80% through 80mesh

Assay(HPLC)

98%

Loss on drying

≤6.5%

Loose Bulk Density

0.322g/ml

https://www.china-sinoway.com/products/n-acetyl-l-carnosine-powder-56353-15-2.html

#nacetyl #carnosine #powder

Basic Information of Febuxostat Intermediates 161798-03-4

CAS No. of key intermediates: 161798-03-4

Other Names: Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate

MF: C14H13NO4S

Purity: 98.0% min

Appearance: Yellow powder, Yellow powder

Usage of Febuxostat Intermediates 161798-03-4

Febuxostat Intermediates for the Treatment of Gout Chronic Hyperuricemia Blood Syndrome.

Gout occurs because the body produces excessive uric acid and decreased renal clearance, uric acid accumulation in the body, resulting in urate crystals in the joints and organs deposition. Therefore, gout treatment is usually taken by means of: uric acid excretion and inhibition of uric acid production, and the use of appropriate measures to improve the symptoms. In vivo uric acid production is related to purine metabolism. In the final purine metabolism step, hypoxanthine produces xanthine under the action of xanthine oxidoreductase (XOR) and further generates uric acid, and the activity of inhibiting this enzyme can be effectively reduced The formation of uric acid. Febuxostat is the most recently developed XOR inhibitor in the world. It effectively treats ventilatory diseases by acting on the oxidase highly selectively, reducing uric acid synthesis in the body and lowering uric acid concentration. For 30 years, allopurinol has been clinically the only drug used to inhibit uric acid production. It is widely used clinically as a gold treatment for gout and has achieved good results in the treatment of gout. Compared with allopurin, febuxostat has obvious advantages:

(1) Allopurinol only inhibited the reduced XOR, while the non-busulfan significantly inhibited the XOR of the oxidized and the reduced XOR. Therefore, its effect of lowering uric acid was stronger and longer;

(2) Since allopurinol is a purine analogue, the effect of other enzymatic activities involving purine and pyridine metabolism is inevitably caused. Therefore, allopurinol treatment, the need for repeated high-dose administration to maintain a high drug level. As a result, serious and even fatal adverse reactions due to drug accumulation are also caused. The non-Boxetan non-purine XOR inhibitors, so have better safety.

https://www.china-sinoway.com/products/febuxostat-intermediates-161798-03-4.html

#febuxostat #intermediates

Basic information of Alprostadil 745-65-3

CAS No .: 745-65-3

Other Names: Prostaglandin E1

MF: C20H34O5, C20H34O5

MW: 354.48

Grade Standard: Medicine Grade

Purity: 99%up

Appearance: White powder

Quality: USP26

Usage of Alprostadil 745-65-3

Alprostadil is used in maintaining a patent ductus arteriosus in newborns

Alprostadil is also as urethral suppositories and in injectable form

Alprostadil is also used for critical limb ischemia

COA of Alprostadil 745-65-3

Items

Specifications

Results

Appearance

White to off-white powder

Complies

Identification

HPLC retention time of sample complies with that of known sample

Complies

Water

≤0.5%

0.03%

Residual solvents

≤0.5%

0.02%

Residual on ignition

≤0.5%

0.20%

Related substances

PGAI: ≤0.5%

Undetected

PGBI: ≤0.5%

Undetected

13,14-Dihydro-PGEI: ≤0.5%

Undetected

Other impurities: ≤ 0.5%

Undetected

Assay

95.0%~105.0%

99.00%

https://www.china-sinoway.com/products/alprostadil-powder-745-65-3.html

#alprostadi #bulk

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