Apr 23, 2024
Increased Oxidative Stress and Decreased Sirtuin-3 and FOXO3 Expression Following Carotid Artery Intimal Injury in Hyperlipidemic Yucatan Microswin
Hypercholesterolemia is a major risk factor for atherosclerosis as oxidized-low-density lipoproteins (ox-LDL) contribute to the formation of foam cells and inflammation. Increased immune cell infiltration and oxidative stress induce instability of a plaque.
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Hematoxylin and eosin staining of left and right ascending pharyngeal arteries (APA - equivalent to internal carotid arteries) in 30% ethanol (vehicle) and TAK-242 treated microswine.Â