Going Through NCBI in Numerical Order

No one asked and yet here I am

[geneaday]

Welcome to Gene a Day

I'm insane and I'm going through the entire NCBI Gene Database one gene at a time. Why? Why not!

Posts will appear at midnight UTC-4 (midnight at Bethesda, Maryland) and follow this format:

Symbol:

Full Name:

Type:

RefSeq Status:

Organism:

Sources: NCBI; UniProt

There might be a description sometimes and this format may change depending on the gene.

Asks are always open and you can submit things like blasts, charts, and anything bioinformatic related.

I will skip discontinued and replaced records.

[geneaday]

NCBI Gene 14

Symbol: AAMP

Full Name: angio associated migratory cell protein

Type: Protein Coding

RefSeq Status: Reviewed, Experimental evidence at the protein level

Organism: Homo sapiens, chromosome 2

Description: The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion.

Subcellular Location: Plasma Membrane, Cytoplasm

Sources: NCBI; UniProt

[geneaday]

NCBI Gene 13

Symbol: AADAC

Full Name: arylacetamide deacetylase

Type: Protein Coding

RefSeq Status: Reviewed, Experimental evidence at protein level

Organism: Homo sapiens, chromosome 3

Description: Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.

Subcellular Location: Endoplasmic reticulum

Sources: NCBI; UniProt

[geneaday]

NCBI Gene 12

Symbol: SERPINA3

Full Name: serpin family A member 3

Type: Protein Coding

RefSeq Status: Reviewed, Experimental evidence at the protein level

Organism: Homo sapiens, chromosome 14

Description: Serpin family A member 3 is from the serpin family, which inhibit serine proteases. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Subcellular Location: Secreted

Sources: NCBI; UniProt

[luulapants]

Story time:

In middle school biology, we did an experiment. We were given yams, which we would sprout in cups of water. We then had to make hypotheses about how the yams would grow, based on descriptions of yam plants in our books, and make notes of our observations as they grew.

Here’s what was supposed to happen: we were supposed to see that the actual growth of the plant did not resemble our hypotheses. We were then supposed to figure out that these were, in fact, sweet potatoes.

What actually happened was that every single student in every single class lied in their notes so that their observations perfectly matched their hypotheses. See, everyone assumed the mismatch meant they had done something wrong in the process of growing the plant or that they had misunderstood the dichotomous key or the plant identification terminology. And, thanks to the wonders of a public school education, everyone assumed the wrong results would get us a failing grade. We were trying to pass. We didn’t want to get bitched out by the teacher. Curiosity, learning, science - that had nothing to do with why we were sitting in that classroom. So we all lied.

The teacher was furious. She tried to fail every student, but the administration stepped in and told her she wasn’t allowed to because a 100% fail rate is recognized as a failure of the teacher, not the class. It wasn’t even her fault, really, though her being a notorious hard-ass didn’t help. It was a failure of the entire educational system.

So whenever I see crap like Elizabeth Holmes’s blood test scam or pharmaceutical trials which are unable to be replicated or industry-funded research that reaches wildly unscientific conclusions, I just remember those fucking sweet potatoes. I remember that curiosity dies when people are just trying to give their superiors the “right” answers, so they can get the grade, get the job, get the paycheck. It’s not about truth when it’s about paying rent. There’s no scientific integrity if you can’t control for human desperation.

[geneaday]

NCBI Gene 11

Symbol: NATP

Full Name: N-acetyltransferase pseudogene

Type: Pseudo

RefSeq Status: Inferred

Organism: Homo sapiens, chromosome 8

Sources: NCBI

[geneaday]

NCBI Gene 10

cSymbol: NAT2

Full Name: N-acetyltransferase 2

Type: Protein Coding

RefSeq Status: Reviewed, Experimental evidence at the protein level

Organism: Homo sapiens, chromosome 8

Description: One of the two N-acetyltransferase (NAT) genes in the human genome. The enzyme this gene encodes an both activate and deactivate arylamine as well as hydrazine drugs and carcinogens. Polymorphisms in this gene is responsible for both N-acetylation polymorphism as well as higher incidences of cancer and drug toxicity.

Subcellular Location: Cytoplasm

Sources: NCBI; UniProt

[peatbogbodyhasmoved]

“I very proudly entered the forestry school as an 18-year-old and telling them that the reason that I wanted to study botany was because I wanted to know why asters and goldenrod looked so beautiful together. These are these amazing displays of this bright, chrome yellow and deep purple of New England aster, and they look stunning together. And the two plants so often intermingle rather than living apart from one another, and I wanted to know why that was. I thought that surely in the order and the harmony of the universe, there would be an explanation for why they looked so beautiful together. And I was told that that was not science, that if I was interested in beauty, I should go to art school. Which was really demoralizing as a freshman, but I came to understand that question wasn’t going to be answered by science, that science, as a way of knowing, explicitly sets aside our emotions, our aesthetic reactions to things. We have to analyze them as if they were just pure material, and not matter and spirit together. And, yes, as it turns out, there’s a very good biophysical explanation for why those plants grow together, so it’s a matter of aesthetics and it’s a matter of ecology. Those complimentary colors of purple and gold together, being opposites on the color wheel, they’re so vivid, they actually attract far more pollinators than if those two grew apart from one another. So each of those plants benefits by combining its beauty with the beauty of the other. And that’s a question that science can address, certainly, as well as artists. And I just think that “Why is the world so beautiful?” is a question that we all ought to be embracing.”

— Robin Wall Kimmerer, “The Intelligence of Plants”, from the podcast On Being with Krista Tippett

[geneaday]

NCBI Gene 9

Symbol: NAT1

Full Name: N-acetyltransferase 1

Type: Protein Coding

RefSeq Status: Reviewed, Experimental evidence at the protein level

Organism: Homo sapiens, chromosome 8

Description: One of the two N-acetyltransferase (NAT) genes in the human genome. The enzyme this gene encodes catalyzes acetyl group transfer from acetyl-CoA to different arylamine and hydrazine substrates as well as helping in metabolizing various drugs and other xenobiotics.

Subcellular Location: Cytoplasm

Sources: NCBI; UniProt

[geneaday]

NCBI Gene 3

Symbol: A2MP1

Full Name: alpha-2-macroglobulin pseudogene 1

Type: Pseudo

RefSeq Status: Validated

Organism: Homo sapiens, chromosome 12

Sources: NCBI

[geneaday]

NCBI Gene 2

Symbol: A2M

Full Name: alpha-2-macroglobulin

Type: Protein Coding

RefSeq Status: Reviewed, Experimental evidence at protein level

Organism: Homo sapiens, chromosome 12

Description: Alpha-2-macroglobulin is a protease inhibitor and a cytokine transporter. Using a bait-and-trap mechanism, alpha-2-macroglobulin inhibits a variety of proteases. Alpha-2-macroglobulin also inhibits inflammatory cascades. A2M is implicated in Alzheimer's Disease due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits.

Subcellular Location: Secreted

Sources: NCBI; UniProt

[geneaday]

NCBI Gene 1

Symbol: A1BG

Full Name: alpha-1-B glycoprotein

Type: Protein Coding

RefSeq Status: Reviewed, Experimental evidence at protein level

Organism: Homo sapiens, chromosome 19

Description: Alpha-1-B glycoprotein has an unknown function but there is an overexpression of A1BG in the pancreatic juice of patients with pancreatic ductal adenocarcinoma.

Subcellular Location: Secreted

Sources: NCBI; UniProt