JMD Histology Inc. & Histologistics Incorporated Human Liver Rhodanine stain for copper. Excess copper is found in the cytoplasm of cells bound to copper-associated protein. DMAB-rhodanine is a bidentate chelating agent, that has a strong affinity for proteinaceous copper deposits. Increased amounts of copper are found in the liver in several disease states including Wilson’s disease, the excess copper has a toxic effect causing liver damage ranging from acute hepatitis and advanced cirrhosis. copper deposits brick red, nuclei: pale blue, bile: green













