Nick MD

GC. Be the best na be the be the at kakain ng sistema.

[copingnurse-deactivated20240217]

Me, when the patient’s family refuses every med & treatment....

[freshrn]

Lol the absolute best gif for this situation.

[bpod-bpod]

No Ear-fects

These ghostly blobs are actually inner ear hair cells, stained with a fluorescent dye. Sound waves cause stereocilia, tiny hairs on these cells, to vibrate. A minute pore on the surface, called an ion channel, then lets in a wave of charged particles, starting a signal which passes along nerves to your brain where it gets interpreted. Precisely which gene codes for the pore has yet to be identified, but it could be valuable in studying hearing disorders. Researchers recently examined a group of channels, called the TRP channels, which looked like good candidates. The cells in the image are from a normal mouse (top) and from a mouse missing one of the TRP channels (below). Unfortunately, none of the TRP channels caused any difference in hearing ability. Although it takes time, this brings scientists closer to identifying the channel and studying what affects it.

Written by Esther Redhouse White

Image from work by Xudong Wu and Artur A. Indzhykulian, and colleagues

Department of Neurobiology, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts, USA

Image originally published under a Creative Commons Licence (BY 4.0)

Published in PLOS One, May 2016

You can also follow BPoD on Twitter and Facebook

[journal-of-science]

Breakthrough cancer research uses Optogenetics to obliterate cancer cells http://www.jasonbuell.com/2016/07/optogenetics-kill-cancer-cells/

[nickaneparaffin]

Generation Why (Y)

Conceited, cynical, disrespectful, megalomaniac, narcissistic, and “you know nothing”. Have you been depicted as such? If yes, do we know nothing but to glamorize and herald ourselves, always that keen towards our superficial well-being and suffered miserably skin deep?

[medresearch]

Mouse Study Suggests Autism is Not Just a Disorder of the Brain

Autism spectrum disorders (ASD) have generally been though to be caused by deficits in brain development, but a mouse study from Harvard University, suggests that the disorder may also affect the peripheral nerves found throughout the limbs and digits.

The Harvard researchers found that aspects of ASD, including the perception of touch and the presence of anxiety and social abnormalities, are linked to defects in the parts of the nervous system that communicate sensory information to the brain.

“An underlying assumption has been that ASD is solely a disease of the brain, but we’ve found that may not always be the case,” said senior author David Ginty, the Edward R. and Anne G. Lefler Professor of Neurobiology at Harvard Medical School and a Howard Hughes Medical Institute investigator. “Advances in mouse genetics have made it possible for us to study genes linked to ASD by altering them only in certain types of nerve cells and studying the effects.”

Read more

Funding: This study was supported by a Hearst Postdoctoral Fellowship; a SFARI Pilot Award from the Simons Foundation; and NIH grants T32 NS007484-14, DE022750 and NS34814.

Raise your voice in support of expanding federal funding for life-saving medical research by joining the AAMC’s advocacy community.

[mynotes4usmle]

ADH problems

[mynotes4usmle]

Diabetes Insipidus

Dx: 

Water deprivation test = If urine volume remains high, and urine osmolality remains low, is DI. 

Vasopressin test = to dx Central vs. Nephrogenic; If Urine osmolality increases, it’s Central, if it remains low, it’s Nephrogenic.

Tx:

Central DI: intransal desmopressin

Nephrogenic DI: HCTZ, amiloride, Chlorthilidone, indomethacin.

SIADH

Dx:

Euvolemic hyponatremia: <130mEq/L

Plasma osmolality < 270mOsm/kg

Urinary Na >20mEq/L 

Tx:

Tx underlying cause

Fluid restriction (800-1000mL/d)

Demeclocycline (inhibits ADH at V2 Collecting duct). Conivaptan, Tolvaptan (V2 receptor blockers)

Severe SIADH (CNS involvement, eg seizures) Hipertonic saline 3% (200-300ml IV in 3-4h)

[fandom]

Fandometrics In Depth: Game of Thrones Edition

Winter has finally arrived in Westeros. 

Season six of Game of Thrones had everything: Time travel, necromancy, dragons, shame… It also had 7.4 million tagged posts and 8.2 million searches here on Tumblr (that’s through the duration of the season, April 24th to June 26th, 2016). We analyzed literally everything tagged #GOT and #Game of Thrones for this special edition of Fandometrics.

Top Episodes

6x09, “Battle of the Bastards”: 53% of the posts

6x05, “The Door”: 14%

6x04, “Book of the Stranger”: 11%

And the least popular: 6x06, “Blood of My Blood”: only 1.7% of the posts.

Top Characters

Jon Snow had the biggest year (of course) with more than 1.5 million of the 7.4 million GOT posts tagged with character names. To illustrate your absolute favorites, we now bring you charts!

Top Ships

There were more than half a million posts about 13 different pairings during season six. Interestingly, most didn’t use the common portmanteaus (think: Stucky) that are popular with modern ships. 61% of the tags used a classic “character 1 x character 2" naming structure instead. Here are your favorites:

Jon Snow x Sansa Stark, 33% of the posts

Brienne of Tarth x Jaime Lannister, 24%

Brienne of Tarth x Tormund Giantsbane, 15%

And the least favorite: Sansa Stark x Tyrion Lannister, with just 0.22% of the posts.

[nickaneparaffin]

We’re missing Lyanna Mormont in this picture.

[blissfullyignoran-t]

[bvddhist]

+

[nickaneparaffin]

Co-dominance.

[tastefullyoffensive]

[nickaneparaffin]

And it is scary enough to know that those .1% or .01% left are the superbugs that developed a resistance to it.

[nickaneparaffin]

God  Bless Pilipinas!

Today is the day. The day wherein the media are in utmost busy, the day where everybody is in optimistic mode, the day where the coveted promise “Change” will be assumed.                                                        

Change is not coming, change is not the countries that helps us to stand on our own, change is not our leaders, and definitely change is not something you have after you bought something from the store. Change is within us, it is innate, it is there when you were born. You, yourself is predestined to change something and it is for you to find out how to utilize it; either for the good of your well-being and of others or the other way around.

Now, let us unite to use our innate ability to change something regardless of who and why you support that political person during election. Let’s do our best to be the best to our ‘kababayan’ and Pilipinas: Perlas ng Silangan.

[medresearch]

Whole-exome Sequencing Aids in Testing Cancer Treatment

To aid researchers to better match patient tumors with their closest genetic cell line match, ensuring that the cancer cells grown in a dish and used to test treatment accurately represent human tumors, University of Colorado Cancer Center researchers used next-generation sequencing technologies to perform the most detailed DNA-based analysis to date of 25 commonly used bladder cancer cell lines.

“The idea is very simple but very important,” says Dan Theodorescu, MD, PhD, director of the CU Cancer Center. “With our sequencing and transcriptional data, we can figure out which of these cell lines most closely match the human tumors. Once we know which ones match, we should only use these in our experiments in order to have the best chance that our experimental findings then apply to patients and their tumors.”

The study, which was published in the journal Oncogene, used whole-exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25 cell lines commonly used as models of bladder cancer. 

Read more

Funding: This work was in part supported by NIH grants CA143971 and CA075115 for DT; Intramural Research Program of the NIH, the National Cancer Institute, Center for Cancer Research for MLN and MD; National Library of Medicine T15 training grant LM009451 for NW; Shenzhen municipal science and technology project CXZZ20140826163906370 for SW.

Raise your voice in support of expanding federal funding for life-saving medical research by joining the AAMC’s advocacy community.

[nickaneparaffin]

YES! After four long years of studying, clinical exposures, lab works, community immersions and seminars. I can now say that I am couldn’t been more ready to face new challenges and endeavors that awaits me. Of course I wouldn’t be here if not with those people who really backs me up and cheered me, through sickness and in health LOL. You all guys rocks! Thank you for being there in times of need. More than appreciated than ever! 

Thank you.

Thank you God. 

Now...let the medical school battle royale begin.

Nick Joseph Cacal Montealto Bachelor of Science in Biology major in Preparatory Medicine Cum Laude

[medical-gal]

Not serology but parasitemia needs to be confirmed by parasitologist. This test proves not antibodies but the presence plasmodium so for active infection

[bioproblemsofficials-deactivate]

Yup. Merong function sa MS Excel where you can do stat anal. Here’s how to install it:

For MS Excel 2013 1. Open MS Excel. 2. Click the File tab, then Options. 3. Click Add-ins, then in “Manage”, choose Excel Add-ins then click go. 4. Select Analysis Toolpak, Analysis Toolpak - VBA, and Solver Add-in, then click ok.

For MS Excel 2010 1. Open MS Excel. 2. Click the Microsoft Office button, then Excel options. 3. Click Add-ins, then in “Manage”, choose Excel Add-ins then click go. 4. Select Analysis Toolpak, Analysis Toolpak - VBA, and Solver Add-in, then click ok.

To be able to use the function after installing it: 1. Click Data, then Data Analysis. 2. Choose the statistical tool na gagamitin mo, then click ok.

Yung nga lang, hindi ka makakapag-post hoc analysis, if necessary. But if you know how to do the post stat anal, then perhaps, pwede mo syang imanual via MS Excel. I did it para sa thesis ko last school year, and ok naman. :)

And yes, you can use other software like SPSS, Stata, SOFA Stat, GraphPad, and other softwares out there. :)

Admin DNA/Ser Deoxy

#BioProblems #BioTips #Biostatistics

[nickaneparaffin]

This will help my stat anal after I gathered data

[nickaneparaffin]

#BangonKaibigan Official Music Video done by me LOL

[nickaneparaffin]

SO RANDOM

[nickaneparaffin]

Just the TYPICAL ME

mmkayy nothing much to do and I guess I just finished all my reading beyond "the my self-deadline" -_-

Yeah Preparatory Med student life is pretty boring for some, but hey! I enjoy this life and I don't suck at this, actually I do excel *wink*.