Quality Herb

Qualityherb We specialize in herbal extract and the development of the most effective and specialized botanical ingredients for the Pharmaceutical, Nutraceutical and Cosmetic industries. Furthermore, we are dedicated to combining the characteristics of each herb by our own scientific research in order to develop the optimal formulation.

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The Pursuit of Purity: Sourcing Notoginseng Total Saponins 75% HPLC from China

In the botanical extract industry, words like "natural" and "herbal" are frequently used, but for manufacturers and formulators, one word carries more weight than any other: pure. When developing pharmaceutical intermediates, dietary supplements, or functional cosmetics, the presence of impurities, residual solvents, or inconsistent active compound ratios can derail an entire product launch.

This is why the search for reliable China supplier wholesale Pure ingredients has become a strategic priority for companies worldwide. Among the most sought-after botanicals in traditional Chinese medicine, Panax Notoginseng stands out for its remarkable cardiovascular benefits. However, harnessing those benefits requires an extract that meets the highest standards of purity and potency. Today, we examine what it truly means to source Notoginseng Total Saponins 75% HPLC as a pure ingredient and how the Chinese wholesale market delivers on that promise.

Defining "Pure" in the Context of Botanical Extracts

Purity in herbal extracts is not simply about removing dirt or physical debris. It is a comprehensive concept that encompasses chemical composition, contaminant levels, and consistency. When a supplier advertises Notoginseng Total Saponins 75% HPLC, they are making a specific claim about the concentration of bioactive compounds in the final powder.

The "75%" refers to the total saponin content, measured specifically by High-Performance Liquid Chromatography (HPLC). This method separates the individual components of the extract, allowing the manufacturer to quantify not just a vague "total" but the exact levels of key markers such as:

Notoginsenoside R1

Ginsenoside Rg1

Ginsenoside Re

Ginsenoside Rb1

Ginsenoside Rd

A truly pure ingredients supplier will provide a Certificate of Analysis (COA) that breaks down each of these compounds individually, ensuring that the ratio matches the natural profile of high-quality Panax Notoginseng root. Furthermore, purity extends to what is not in the powder. Reputable suppliers test for heavy metals (lead, arsenic, cadmium, mercury), microbiological contaminants (bacteria, yeast, mold), and residual solvents from the extraction process. Meeting pharmacopoeial standards such as CP2025 (Chinese Pharmacopoeia), USP, or EP is the hallmark of a pure ingredient.

The China Advantage: Where Purity Begins at the Source

Sourcing Notoginseng Total Saponins 75% HPLC from China is not merely a matter of cost-efficiency; it is a matter of authenticity. Panax Notoginseng is indigenous to China, with the primary cultivation regions located in the mountainous areas of Yunnan and Guangxi provinces . The soil, climate, and altitude of these regions contribute unique characteristics to the saponin profile that cannot be replicated elsewhere.

Leading China supplier wholesale Pure ingredients operations leverage this geographic advantage through vertical integration. Instead of purchasing raw material from spot markets, these manufacturers often operate their own Good Agricultural Practices (GAP) farms or maintain direct, long-term contracts with local growers. This control at the agricultural level allows them to:

Ensure varietal authenticity: Confirming that the plants are true Panax Notoginseng, not substitutes or adulterants.

Monitor growing conditions: Managing pesticide use, irrigation, and harvest timing to optimize saponin accumulation.

Traceability: Maintaining documentation from seed to finished extract.

The Extraction Process: Engineering Purity

Converting a fibrous root into a fine, light-yellow powder containing Notoginseng Total Saponins 75% HPLC requires sophisticated technology. Chinese manufacturers have invested heavily in state-of-the-art extraction facilities that rival those found in Europe or North America.

The typical process involves several stages designed to isolate and concentrate the saponins while removing unwanted plant materials:

Extraction: The dried root material is processed with food-grade ethanol or water to draw the saponins out of the plant matrix.

Concentration and Separation: The liquid extract is concentrated under vacuum to preserve heat-sensitive compounds. Various separation techniques, including macroporous resin chromatography, are used to selectively adsorb the saponins while washing away sugars, starches, and pigments.

Drying: The purified saponin solution is spray-dried or vacuum-dried into a fine powder. This step must be carefully controlled to prevent degradation of the actives.

Screening and Milling: The final powder is milled to a uniform particle size to ensure consistent flow and mixing properties for downstream manufacturing .

A supplier committed to pure ingredients will validate each of these steps, ensuring that the process itself does not introduce contaminants.

Why Purity Matters for Different Applications

The specification of Notoginseng Total Saponins 75% HPLC is versatile enough to serve multiple industries, but the requirement for purity remains constant across all applications.

Pharmaceutical Intermediates: For companies developing drugs for cardiovascular conditions, cerebral ischemia, or diabetic retinopathy, purity is non-negotiable. Impurities can interfere with pharmacological activity or introduce safety risks in injectable formulations. The 75% HPLC standard provides the consistency required for reproducible clinical outcomes .

Dietary Supplements: In the crowded supplement market, efficacy drives repeat purchases. A pure, standardized extract ensures that each capsule delivers the promised dose of active saponins, building consumer trust in the brand.

Cosmetics and Personal Care: When used in anti-aging serums or creams, the extract must be free of microbial contaminants and heavy metals to be safe for topical application. The anti-inflammatory and antioxidant properties of notoginseng saponins are increasingly valued in cosmeceuticals, but only if the ingredient base is clean .

Navigating the Wholesale Market for Pure Ingredients

For procurement managers and R&D directors, finding a trustworthy China supplier wholesale Pure ingredients partner requires due diligence. The market includes many players, but those focused on purity distinguish themselves through transparency.

Key indicators of a reliable supplier include:

Third-Party Testing: They regularly submit samples to independent laboratories like SGS, Eurofins, or Bureau Veritas for verification of their in-house COAs .

Certifications: Look for ISO9001 (Quality Management), ISO22000 (Food Safety), and applicable organic or religious certifications (Kosher, Halal) .

Sample Availability: A supplier confident in their purity will provide a sample for pre-qualification testing, allowing you to verify the HPLC profile in your own lab before committing to a bulk order .

Conclusion

As the global demand for natural, plant-based therapies continues to grow, the ingredients that power these products must meet increasingly rigorous standards. Notoginseng Total Saponins 75% HPLC represents a benchmark of quality in the botanical world—a precise, well-characterized extract with decades of traditional use and modern scientific validation behind it.

By partnering with a specialized China supplier wholesale Pure ingredients manufacturer, companies gain access to authentic raw materials, advanced processing technology, and a commitment to purity that ensures their final products are safe, effective, and consistent. In an industry where reputation rests on results, starting with a pure ingredient is not just a preference; it is a necessity.

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The Green Standard: Sourcing Sodium Copper Chlorophyllin GB/USP from Chinese Suppliers

There is something almost alchemical about the transformation of green leaves into a stable, water-soluble powder that retains the colour of life itself. Sodium copper chlorophyllin—the semi-synthetic derivative of chlorophyll—represents one of the most successful marriages between nature's chemistry and industrial processing. Today, this vivid green powder has found its way into food, pharmaceuticals, cosmetics, and dietary supplements across the globe. And for manufacturers seeking consistent quality, Chinese suppliers have become the primary source, offering product that meets the two most important international standards: GB (Guobiao, the Chinese national standard) and USP (United States Pharmacopeia) .

What Is Sodium Copper Chlorophyllin?

Sodium copper chlorophyllin is a stable, water-soluble derivative of chlorophyll, the naturally occurring pigment that gives plants their green hue . It is produced through a carefully controlled process: chlorophyll is first extracted from plant sources such as alfalfa, grass, lucerne, or nettle, then subjected to saponification to remove the magnesium atom at the centre of the molecule, followed by replacement with copper . The resulting compound is a green to black powder that dissolves readily in water, yielding brilliant emerald-green solutions .

The chemical formula is C₃₄H₃₁CuN₄Na₃O₆, and it carries the CAS number 11006-34-1 . In the world of food additives, it is designated as INS 141(ii) in the Codex Alimentarius and E 141(ii) in Europe .

The GB and USP Standards: What They Mean for Buyers

When a Chinese supplier offers sodium copper chlorophyllin that meets GB or USP standards, they are signalling compliance with rigorous quality parameters that matter to international buyers.

The GB Standard (GB26406-2011)

China's national standard for sodium copper chlorophyllin, GB26406-2011, sets specific requirements for purity and quality. Key parameters from this standard include :ParameterGB26406-2011 RequirementExtinction coefficient (E¹%₁cm at 405nm)≥ 568Absorbance ratio (E405/E630)3.2 ~ 4.0pH (1% solution)9.0 ~ 10.7

These specifications ensure batch-to-batch consistency and serve as reliable markers of quality. The extinction coefficient, in particular, is a critical measure of colour strength and purity—the higher the number, the more intense and pure the colour.

The USP Standard

For pharmaceutical applications, compliance with the United States Pharmacopeia is often required. USP-grade sodium copper chlorophyllin meets additional testing requirements for identity, purity, and contaminants, making it suitable for use in dietary supplements and medicinal products.

Additional Quality Parameters

Beyond the pharmacopoeial specifications, reputable suppliers test for:

Total copper content: Typically above 4.0% as specified in pharmaceutical monographs 

Heavy metals: Lead, arsenic, cadmium, and mercury within strict limits

Microbiological purity: Total plate count, absence of pathogens

Loss on drying: Typically ≤ 5-7%

Residual solvents: Within pharmacopoeial limits

The Chinese Supplier Landscape

China has emerged as a leading source of sodium copper chlorophyllin, with manufacturing expertise concentrated in several provinces.

Key Manufacturing Hubs

Hebei Province hosts established producers like Baoding Faithful Industry Co., Ltd., which focuses on plant extracts for nutraceutical, cosmetic, and pharmaceutical applications. The company emphasizes production via advanced technique and up-to-date equipment, ensuring product quality reaches international levels and meets EU and US standards .

Shandong Province is home to multiple manufacturers including Shandong Lanmo Biotech Co., Ltd., which specializes in natural food colorants including sodium copper chlorophyllin, sodium magnesium chlorophyllin, oil-soluble chlorophyll, and other natural pigments . The concentration of producers in Shandong reflects the region's strength in fermentation and extraction technology.

Production Process

Manufacturers typically follow a consistent production flow:

Raw material selection: High-quality alfalfa, mulberry leaves, or silkworm feces serve as chlorophyll sources

Extraction: Solvent extraction using food-grade solvents removes chlorophyll from plant material

Saponification: Alkaline treatment removes the central magnesium atom

Copper insertion: Copper salts are introduced to form the stable copper complex

Purification: Multiple purification steps remove impurities and by-products

Drying: Spray-drying or vacuum drying produces the final powder

Standardization: Testing against GB or USP specifications ensures compliance

Quality control: Comprehensive analysis including spectrophotometry, HPLC, and heavy metal testing

The extinction coefficient at 405nm serves as a key quality indicator during production, with values exceeding 568 indicating high purity .

Quality Certifications

Reputable Chinese suppliers maintain certifications including:

ISO 9001 (quality management)

GMP (good manufacturing practices)

HACCP (hazard analysis critical control points)

Kosher and Halal certifications for appropriate markets

FSSC 22000 for food safety management

Many suppliers also offer third-party testing through laboratories such as SGS, Eurofins, or Bureau Veritas, providing additional verification for international buyers.

Applications Across Industries

The versatility of sodium copper chlorophyllin supports multiple commercial applications.

Food and Beverage Industry

As a food colorant, sodium copper chlorophyllin imparts stable green hues to a wide range of products. Typical applications include :

Confectionery: Candies, gums, and mints

Beverages: Soft drinks, juice blends, and functional drinks

Dairy products: Yogurts, ice cream, and flavoured milks

Bakery products: Fillings, icings, and decorative elements

Soups, sauces, and seasonings: Where natural green colour is desired

Convenience foods: Ready meals and snack foods

In the United States, sodium copper chlorophyllin is permanently listed as exempt from certification and may be used to colour citrus-based dry beverage mixes at levels not exceeding 0.2% in the dry mix .

In Europe, copper complexes of chlorophyllins (E 141ii) are authorized for use at quantum satis levels—meaning no maximum level is specified—in specific foods and beverages .

Pharmaceutical and Health Applications

Sodium copper chlorophyllin has documented therapeutic applications. In China, it is available in tablet form (20mg) for medical use, with indications including :

Leukopenia (reduction in white blood cells)

Acute and chronic hepatitis as an adjunctive treatment

Hepatoprotective effects: The compound appears to activate hepatic reticuloendothelial cells, promoting liver function recovery and enhancing hepatocyte resistance to damage

The pharmacological mechanism involves stimulation of hematopoietic stem cells and modulation of bone marrow stromal cells, promoting recovery of hematopoietic function . Studies suggest chlorophyllin increases white blood cell counts by enhancing sympathetic nervous system activity and facilitating neutrophil release from bone marrow, with involvement of hepatic and adrenal function .

Beyond these established uses, chlorophyllin has been investigated for:

Chemopreventive properties: It forms non-covalent complexes with mutagenic and carcinogenic molecules, potentially inhibiting cancer initiation and progression 

Radiation protection: Animal studies suggest it may mitigate radiation-induced hematopoietic syndrome by increasing hematopoietic stem cell abundance and enhancing granulopoiesis 

Antioxidant, antiapoptotic, and immunostimulatory effects 

Clinical trials have explored chlorophyllin for conditions including glioblastoma (Phase 2), glioma (Phase 2), and haemorrhage (Phase 2) . It has also been investigated for improving quality of life in individuals with fecal incontinence due to spinal cord injury, bowel cancer, psychotic disorders, or following colostomy or ileostomy .

Cosmetics and Personal Care

In cosmetics, sodium copper chlorophyllin serves both functional and aesthetic purposes. It may be used in:

Dentifrices: In the United States, potassium sodium copper chlorophyllin may be used to colour dentifrices that are drugs at levels not exceeding 0.1%, and in cosmetics at up to 0.1% in combination with specifically listed substances 

Skincare products: For its antioxidant and soothing properties

Colour cosmetics: Providing natural green tones

Dietary Supplements

The supplement industry uses sodium copper chlorophyllin in tablets and capsules, often marketed for internal deodorizing properties, immune support, and general wellness. Its water solubility makes it suitable for various delivery formats .

Animal Health

Chlorophyllin has also found application as a fungicide and microbiocide in agricultural settings, though regulatory status varies by region .

Regulatory Status and Safety

Sodium copper chlorophyllin has undergone extensive safety evaluation by international bodies.

JECFA Evaluation

The Joint FAO/WHO Expert Committee on Food Additives (JECFA) established an Acceptable Daily Intake (ADI) of 0-15 mg/kg body weight for both chlorophylls, copper complexes (13th Report, 1969) and chlorophyllins, copper complexes sodium and potassium salts (22nd Report, 1978) .

More than 55 food categories have maximum permitted levels for chlorophylls and chlorophyllins in the Codex General Standard of Food Additives .

European Status

The European Food Safety Authority (EFSA) re-evaluated copper complexes of chlorophylls (E 141i) and chlorophyllins (E 141ii) in 2015, withdrawing the previous ADI but confirming their safety for use at quantum satis levels in specified foods .

United States Status

In the US, sodium copper chlorophyllin was permanently listed in 2002 as exempt from certification and may be safely used for specific applications under 21 CFR regulations .

Acute Toxicity

The acute oral LD₅₀ in mice is reported as > 7000 mg/kg, indicating very low acute toxicity .

Sourcing Considerations for Buyers

When approaching Chinese suppliers for sodium copper chlorophyllin meeting GB/USP standards, several factors warrant attention.

Sampling and Verification

Reputable suppliers offer samples for evaluation, typically 50-100 grams at no cost or for a nominal fee credited toward the first bulk order. This allows you to verify:

Colour intensity and shade

Solubility in your target formulation

pH of solution

Compatibility with other ingredients

Specifications to Verify

Ensure your Certificate of Analysis documents:ParameterTarget SpecificationExtinction coefficient (405nm)≥ 568 (GB)Absorbance ratio (E405/E630)3.2 - 4.0 (GB)pH (1% solution)9.0 - 10.7 (GB) or as specifiedTotal copper≥ 4.0% (pharmaceutical grade)Loss on drying≤ 5-7%Total heavy metals≤ 10 ppmLead (Pb)≤ 2-3 ppmArsenic (As)≤ 1-2 ppmMercury (Hg)≤ 1 ppmCadmium (Cd)≤ 1 ppmTotal plate count≤ 1000-10000 cfu/gYeast & mould≤ 100-1000 cfu/gPathogensNegative

Minimum Order Quantities

Industry standard MOQs typically start at:

1 kilogram for sampling and R&D purposes

25 kilograms for commercial orders (standard fibre drum)

Custom packaging available for larger volumes

Documentation Requirements

Ensure your supplier provides comprehensive documentation including:

Certificate of Analysis with full specifications

Material Safety Data Sheet

Allergen statement

Non-GMO declaration

Kosher/Halal certificates (if required)

Phytosanitary certificate for international shipping

Specification sheet detailing physical and chemical parameters

Batch traceability documentation

Storage and Stability

Sodium copper chlorophyllin should be stored in cool, dry conditions away from direct sunlight and heat—typically sealed containers in temperatures below 25°C with controlled humidity. Under optimal conditions with packaging intact, shelf life extends to 24-36 months from manufacture date.

The compound is sensitive to light during storage; opaque packaging is essential for maintaining colour strength.

Shipping Logistics

Shipping options accommodate various volumes:

Courier services (DHL, FedEx, UPS) for small orders: 3-7 days transit

Air freight for medium volumes: 2-4 days transit

Sea freight (FCL/LCL) for bulk shipments: 10-35 days depending on destination

Major ports of departure include Shanghai, Tianjin, Qingdao, and Guangzhou. Suppliers typically handle export documentation and customs clearance at origin, with delivery terms including FOB, CIF, or EXW.

Note on Pharmaceutical Applications

For pharmaceutical applications, additional considerations apply. The Chinese pharmacopoeia specifies that sodium copper chlorophyllin tablets should contain 90.0% to 115.0% of the labelled amount, with total copper content verified at ≥ 4.0% . Pharmaceutical-grade material requires stricter quality control and documentation.

The Future of an Established Ingredient

Sodium copper chlorophyllin has maintained its position in the global market for decades, and several trends suggest continued relevance. The clean-label movement favours natural colours over synthetic alternatives. The growing interest in plant-based ingredients aligns well with a chlorophyll derivative. And the expanding body of research into chlorophyllin's therapeutic properties—from chemoprevention to radiation protection—opens new opportunities for pharmaceutical and nutraceutical applications.

The compound's stability, water solubility, and brilliant green colour ensure its place in food, beverage, and cosmetic formulations for years to come. Its documented safety profile, backed by decades of use and rigorous evaluation by international bodies, provides confidence to formulators and consumers alike.

For manufacturers and formulators seeking a reliable source of this versatile ingredient, Chinese suppliers offer access with the consistency, certifications, and scalability required for commercial success. Whether destined for a naturally coloured beverage in North America, a liver health supplement in Europe, or a pharmaceutical preparation in Asia, properly sourced sodium copper chlorophyllin meeting GB and USP standards delivers the quality that formulators rely on—batch after batch, year after year.

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The Natural Sweet Revolution: Inside China's Steviol Glycosides Market

The global shift away from refined sugar has created one of the most significant transformations in food history. Consumers demand sweetness without consequences—zero calories, natural origins, and clean labels. At the center of this revolution stands stevia, specifically the compounds that make it sweet: steviol glycosides. For manufacturers and formulators seeking to capitalize on this trend, understanding China's sophisticated supply chain for total steviol glycosides from Stevia rebaudiana extract is essential knowledge.

Understanding Steviol Glycosides

Steviol glycosides are the sweet components found in the leaves of Stevia rebaudiana, a plant native to the rainforests of Paraguay and Brazil that has been used for centuries by indigenous peoples to sweeten beverages . These compounds—primarily stevioside and rebaudiosides—share a common steviol backbone but differ in their sugar attachments, creating distinct sweetness profiles and intensities.

What makes steviol glycosides remarkable is their potency. Depending on the specific glycoside composition and purity level, these extracts deliver sweetness 150 to 450 times greater than sucrose . A compound like Rebaudioside A (Reb-A), considered the best component in stevia extracts for its clean taste, achieves this intensity while contributing virtually no calories .

The chemistry is precise. Steviol glycosides have the molecular formula C38H60O18, appear as white to light yellow powder, and demonstrate stability across wide temperature and pH ranges—properties that make them exceptionally versatile for food manufacturing .

China's Dominance in Global Stevia Production

China has emerged as the undisputed leader in stevia cultivation and processing. Today, more than 90% of the world's stevia is grown in China . This dominance stems from favorable growing conditions, established agricultural expertise, and massive investment in extraction infrastructure.

The concentration of production capacity is staggering. Individual suppliers like Hangzhou Food Ingredients Cloud report monthly production capacity reaching 1,000 tons . Kingherbs Limited in Hunan province maintains 50,000 kilograms per month capacity, operating as an audited supplier since 2007 . This scale enables Chinese manufacturers to serve global demand with consistency and competitive pricing.

Major production clusters have formed across several provinces. Shandong province hosts numerous certified facilities including Tangbaobao Biotechnology's FSSC22000-certified operations, Weifang Tinmu Chemical, and Jining USP International . Hunan province contributes established players like Kingherbs . Shandong's concentration of stevia processing expertise has created a competitive environment benefiting buyers through multiple sourcing options.

Understanding the Specification Spectrum

The market for total steviol glycosides offers products across a broad purity range, each serving distinct applications and price points.

Entry-Level Specifications (50-75%) provide cost-effective solutions for mass-market products. Stevioside STV50, standardized at 50% total steviol glycosides, offers balanced sweetness with minimal herbal aftertaste, making it suitable for beverages, confectionery, and light-processed foods where subtle sweetness enhancement is desired . Steviol Glycosides 75 (SG75) represents a mid-tier option with exceptional sweetness quality and reduced bitterness, delivering 150-170 times sucrose sweetness . Tangbaobao's SG75 product, produced in FSSC22000-certified facilities, exemplifies this category with its smooth taste profile and excellent solubility in water, ethanol, and glycerin .

Mid-Range Specifications (80-90%) target premium applications requiring cleaner taste profiles. Stevioside STV80 delivers advanced sweetness quality with minimal herbal notes, ideal for high-end beverages, gourmet confectionery, and quality dairy products . Rebaudioside A 90% products, containing ≥90% Reb-A and ≥95% total steviol glycosides, represent the sweetest components extracted from specially planted stevia materials . Qufu Xiangzhou Stevia Products specializes in these higher-purity extracts for food, beverage, and nutrition applications .

High-Purity Specifications (95-99%) serve demanding pharmaceutical and premium food applications. Products meeting JECFA standards with total steviol glycosides exceeding 95% have received regulatory approval from US FDA (2008) and European regulators (2011) . Hangzhou Food Ingredients Cloud offers ≥95% total steviol glycosides with Reb-A content ≥90%, meeting FCC standards with tight specifications for heavy metals (all ≤1 ppm) and microbiological purity .

Quality Parameters and Testing

Professional buyers evaluate steviol glycosides against comprehensive quality specifications that extend beyond simple purity percentages.

Physical and Chemical Properties provide initial quality indicators. Products should appear as white to light yellow powder with characteristic sweet taste and no off-odors . Loss on drying typically falls below 4-6%, ash content under 0.1-1%, and pH in 1% solution between 4.5-7.0 depending on specific product . Specific optical rotation between -30° and -38° confirms proper stereochemistry .

Purity Verification requires analytical rigor. High-Performance Liquid Chromatography (HPLC) provides definitive quantification of individual glycosides and total content . Reputable suppliers provide Certificates of Analysis documenting stevioside, rebaudioside A, and other glycoside proportions alongside total steviol glycosides.

Heavy Metal and Safety Testing ensures consumer safety. Responsible manufacturers maintain strict limits: lead ≤1 ppm, arsenic ≤1 ppm, cadmium ≤1 ppm, mercury ≤1 ppm . Solvent residues fall within permissible ranges—methanol ≤200 ppm, ethanol ≤5000 ppm .

Microbiological Purity confirms suitability for food applications. Specifications require total plate count ≤1000 CFU/g, negative for pathogens including Salmonella, E. coli, and Staphylococcus, and yeast/mold within acceptable limits .

Certifications and Compliance

Leading Chinese stevia suppliers maintain comprehensive certifications enabling global distribution. ISO9001 for quality management and FSSC22000 or ISO22000 for food safety appear standard among established manufacturers . Jining USP International exemplifies this commitment with ISO9001, FSSC22000, Kosher, and Halal certifications .

For specific markets, additional credentials matter. Kosher and Halal certifications expand accessibility to religious dietary markets . Organic certifications (USDA, EU) appeal to premium segments. JECFA compliance ensures acceptance in regulated markets worldwide .

Tangbaobao Biotechnology's FSSC22000-certified facility produces SG75 with available Halal and Organic certifications, demonstrating the certification depth available from quality suppliers .

Applications Across Product Categories

Total steviol glycosides find applications across an extraordinary range of products, reflecting their versatility and regulatory acceptance.

Beverages represent the largest application category. Clear soft drinks, functional waters, ready-to-drink teas, and flavored fermented milks all benefit from stevia's stability in both hot and cold processing . The combination of stevia with high fructose syrup or other sweeteners creates optimal taste profiles in low-calorie colas and health drinks .

Confectionery and Bakery applications leverage heat stability. Chocolates, candies, sugar-free gum, cakes, and pastries maintain sweetness through thermal processing without degradation . Steviol glycosides perform exceptionally in hard candies when combined with sugar alcohols like maltitol and lactitol .

Dairy Products including yogurt, ice cream, and flavored milk benefit from clean sweetness profiles that complement rather than mask dairy flavors . STV80's enhanced purity makes it particularly suitable for premium dairy applications .

Health and Pharmaceutical applications represent growing segments. Nutritional supplements, protein powders, meal replacements, and pharmaceutical syrups utilize stevia's zero-calorie, non-glycemic properties . Liquid medications benefit from the sweetness without contributing to sugar intake.

Tabletop Sweeteners provide direct consumer access, with products positioned for diabetic and weight-conscious consumers .

Leading Suppliers and Capabilities

China's steviol glycosides market features numerous established suppliers with distinct capabilities.

Shandong Tangbaobao Biotechnology offers comprehensive stevia extract lines including SG75, STV50, STV80, and higher purities from their FSSC22000-certified facility . Their technical parameters for SG75 demonstrate exceptional quality: ≥75% total steviol glycosides, ≤5% moisture, ≤0.8% ash, with 36-month shelf life .

Kingherbs Limited (Hunan) operates as a Diamond Member since 2007 with 50,000kg/month capacity. Their stevia leaf extract specifications focus on stevioside content with applications across multiple categories .

Hangzhou Food Ingredients Cloud offers ≥95% total steviol glycosides with tight specifications: loss on drying ≤4%, ash ≤0.1%, pH 5.5-7.0, and all heavy metals ≤1 ppm .

Weifang Tinmu Chemical (Shandong) supplies steviol glycosides with 250-450 times sucrose sweetness, emphasizing cost savings exceeding 60% compared to cane sugar. Their 5-year audited supplier status includes SGS/BV certification .

Jining USP International (Shandong) provides multiple specification options including STV95 (≥96% total glycosides) and TSG95STV70 (≥95% total, 70% stevioside). Their comprehensive testing covers heavy metals by ICP-MS and full microbiological panels .

Qufu Xiangzhou Stevia Products specializes in Reb-A products including Reb-A 60% and Stevia 95%, cultivated from their own stevia plantations .

ZIO Chemical supplies stevia sweetener powder with ≥80% total steviol glycosides, detailed specifications including specific rotation (-31 to -38), absorbance (≤0.05), and complete heavy metal profiles .

Pricing Structures and Order Flexibility

The steviol glycosides market accommodates buyers across scales with various pricing models. ZIO Chemical's stevia sweetener powder with ≥80% purity represents commercial-grade pricing, though specific figures require direct inquiry . Weifang Tinmu lists products at approximately $50/kg with minimum orders of 1000kg, targeting larger commercial operations . Hangzhou Food Ingredients Cloud offers flexible minimum orders starting at 1 piece . Kingherbs lists reference FOB price as negotiable with 1kg minimum order, enabling startups and small businesses to access quality materials .

Supplier Evaluation Best Practices

Successful sourcing from Chinese steviol glycosides suppliers follows established patterns. Requesting samples enables verification before commitment—most reputable suppliers provide samples, sometimes complimentary. Clear communication about desired specifications, purity levels, and applications prevents misunderstandings.

Documentation review remains essential. Comprehensive Certificates of Analysis should accompany all shipments, providing detailed test results from accredited methods. Suppliers offering third-party verification (SGS, BV) demonstrate commitment to transparency .

Payment terms and logistics require attention, with established suppliers offering various shipping options and navigating international requirements efficiently.

Market Outlook

The global stevia market continues expanding as consumers and manufacturers alike seek natural, zero-calorie sweetening solutions. Regulatory approvals in major markets including the United States (2008) and European Union (2011) have legitimized steviol glycosides as food additives .

As research continues clarifying optimal glycoside profiles for specific applications, demand for specialized specifications will likely increase. Suppliers investing in rigorous testing, maintaining transparent supply chains, and offering formulation support position themselves advantageously.

Final Thoughts

For businesses seeking natural sweetening solutions with proven consumer appeal, China's total steviol glycosides market offers remarkable depth, technical sophistication, and manufacturing scale. The availability of specifications from 50% to 99% purity enables sourcing matched precisely to application requirements and budget constraints.

The concentration of extraction expertise across Shandong and Hunan provinces creates competitive dynamics benefiting buyers through multiple specification options and service levels. Whether developing mass-market beverages, premium confectionery, pharmaceutical preparations, or tabletop sweeteners, the landscape of Chinese steviol glycosides suppliers offers viable options for virtually every business model.

Success depends on thorough due diligence, clear specification communication, and patient relationship building. Suppliers demonstrating consistent quality, transparent practices, and responsive service position themselves as preferred partners as the natural sweetener revolution continues its global expansion.

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The Unsung Ingredient: Exploring China's Tannic Acid Market from Gallnut Extract

In the world of natural ingredients, some compounds work quietly behind the scenes, essential yet uncelebrated. Tannic acid—specifically food-grade tannic acid derived from Chinese gallnuts—occupies exactly this space. It appears in your glass of wine, your skincare routine, your pharmaceutical formulations, and even industrial processes, yet few recognize its name. For businesses seeking this versatile ingredient, understanding China's sophisticated supply chain for gallnut-derived tannic acid opens doors to quality sourcing at competitive prices.

What Makes Gallnut-Derived Tannic Acid Special

Tannic acid belongs to a class of compounds called hydrolysable tannins—plant polyphenols with the remarkable ability to bind and precipitate proteins . Unlike condensed tannins found in many plants, the tannic acid from Chinese gallnuts (Galla Chinensis) dissolves readily in water, making it exceptionally versatile for food and pharmaceutical applications .

Chinese gallnuts are unique botanical structures—growths formed when parasitic aphids interact with sumac trees (Rhus chinensis Mill.), creating natural factories for tannin production . This traditional raw material, long valued in Chinese medicine for its astringent and antidiarrheal properties, has evolved into a modern industrial ingredient with applications spanning multiple sectors .

The chemical structure of tannic acid—technically a mixture of polygalloyl glucose esters with the formula C76H52O46—enables its characteristic functions: antioxidant activity, antimicrobial effects, and protein-precipitating capabilities .

Leading Suppliers and Manufacturing Capabilities

China's tannic acid market features several established manufacturers with distinct strengths and production philosophies.

Jiurui Biology & Chemistry Co., Ltd., established in 1996 and located in Zhangjiajie Economic Development Zone, Hunan Province, represents perhaps the most significant player . With 130,000 square meters of facilities and over 200 employees, the company claims the greatest gallnut processing capability in China . What sets Jiurui apart is its scientific foundation—chairman Zhao Guofeng holds a Ph.D. in organic chemistry from Nankai University, and the company leverages this academic connection for continuous product development . Their product portfolio includes tannic acid, gallic acid, and propyl gallate, serving pharmaceutical, food, feed, and industrial applications with certifications including ISO9001, HACCP, HALAL, KOSHER, and FAMI-QS .

Dalian Sinobio Chemistry Co., Ltd., established in 2011, offers tannic acid at 90% and 93% specifications from their production site in Jiangxi province . As a Diamond Member on Made-in-China.com with verified business licenses, they emphasize rapid response and sample availability. Their ISO9001 and ISO14001 certifications demonstrate commitment to quality management and environmental standards .

Xian prius biological engineering co.,ltd provides tannic acid at higher purity levels—95% and 98%—positioned at competitive price points between $18-27 per kilogram . Their extensive extraction infrastructure includes multi-functional extraction equipment, reactors, concentration systems, and chromatographic columns, enabling consistent production at scale .

Shaanxi Bolin Biotechnology Co., Ltd offers comprehensive gallnut extract specifications ranging from 40% to 99% tannic acid content, with testing verified through HPLC methodology . Their product lineup includes gallic acid and ellagic acid alongside standard tannic acid, providing buyers with multiple sourcing options from a single supplier .

Shaanxi Laon rounds out the major suppliers with 98% tannic acid available in food and pharmaceutical grades, packaged in convenient 1kg aluminum foil bags . Their Gold Member status on Made-in-China.com and multiple certifications (RoHS, BRC, ISO, FDA, HACCP) indicate commitment to international quality standards .

Quality Specifications and Testing

The tannic acid market demonstrates clear quality tiers that buyers should understand when evaluating suppliers. Common specifications include 81%, 90%, 93%, 95%, and 98% purity, with higher concentrations commanding premium pricing .

Testing methodology matters significantly. Reputable suppliers use High-Performance Liquid Chromatography (HPLC) or UV spectrophotometry for verification . Certificates of Analysis should accompany all shipments, providing detailed results for purity, heavy metals, and microbiological parameters.

Physical characteristics provide additional quality indicators. Tannic acid typically appears as light yellow to brown powder, though color can vary slightly based on processing methods . Particle size specifications ensure consistent handling and formulation properties.

Heavy metal testing represents a critical safety parameter for food-grade applications. Responsible suppliers maintain strict limits for lead, arsenic, cadmium, and mercury, typically ensuring total heavy metals below 10-20ppm .

Food-Grade Applications

Food-grade tannic acid finds applications across multiple product categories. As a food antioxidant, it helps prevent oxidative rancidity in oils and fats, often combined with vitamin E, vitamin C, or gallic acid for enhanced effectiveness . This synergistic approach maximizes shelf-life extension while maintaining natural ingredient profiles.

In beverage processing, tannic acid serves as a clarifying agent for low-alcohol wines and fruit wines, binding with proteins that cause haze and precipitating them for removal . This application leverages the same protein-binding properties that make tannins essential in traditional winemaking.

The compound's antimicrobial properties make it valuable for natural preservation systems . As consumer demand grows for clean-label products, tannic acid offers an alternative to synthetic preservatives, particularly in products where its astringent character complements the flavor profile.

Functional food applications represent a growing category. Tannic acid's documented benefits for gastrointestinal health—including treatment of chronic diarrhea and dysentery—align with traditional uses while meeting modern formulation requirements .

Beyond Food: Pharmaceutical and Industrial Applications

The versatility of gallnut-derived tannic acid extends far beyond food processing. In pharmaceutical applications, it serves as raw material for clearing heat, reducing inflammation, and supporting immune function . Its astringent properties make it valuable for treating local bleeding and formulating products for digestive health .

The cosmetics industry incorporates tannic acid for multiple benefits. Its protein-binding capability helps prevent hair fiber dissolution in shampoos, protecting hair structure during cleansing . In nail products, it increases strength and durability. The compound's free radical scavenging activity—comparable to gallic acid and catechin compounds—makes it valuable for sun protection and skin lightening formulations . Its astringent and antibacterial properties translate effectively to oral care products, with applications in toothpaste for gum protection and bleeding prevention .

Industrial applications demonstrate the compound's remarkable range. In water-based drilling fluids, tannic acid reduces viscosity and fluid loss while improving filter cake quality . Water treatment leverages its flocculation, deoxidation, scale inhibition, and sterilization properties—the hydroxyl and carboxyl groups in its molecular structure bind calcium and magnesium ions, preventing scale formation in boiler systems .

The leather industry represents a traditional application, with tannic acid tanning raw hides into finished leather through protein cross-linking . Printing, dyeing, and metallurgy industries also utilize this versatile compound .

Certifications and Compliance

Leading suppliers maintain certifications demonstrating commitment to quality and safety. ISO9001 for quality management systems appears common among established manufacturers . ISO22000 or HACCP certifications indicate food safety compliance .

For international distribution, additional credentials matter. Kosher and Halal certifications expand market accessibility to religious dietary markets . Organic certifications (USDA, EU) appeal to specific market segments, though availability varies by supplier. REACH registration enables European Union distribution .

Jiurui's comprehensive certification approach—including ISO9001, ISO14000, ISO22000, ISO45001, ISO56005, HACCP, FAMI-QS, HALAL, KOSHER, REACH, and AEO status—exemplifies the credential depth available from top-tier suppliers .

Geographic Manufacturing Clusters

Tannic acid production concentrates in regions with strong botanical extraction expertise and access to gallnut resources. Hunan province, particularly Zhangjiajie, hosts Jiurui, leveraging proximity to Wuling Mountains gallnut resources . Shaanxi province, including Xi'an, hosts multiple suppliers such as Xian prius, Shaanxi Bolin, and Shaanxi Laon, benefiting from established herbal processing infrastructure . Liaoning province (Dalian Sinobio) and Jiangxi province add geographic diversity to supply options .

This distribution provides buyers with multiple sourcing options and competitive dynamics that benefit pricing and service levels.

Pricing Structures and Order Flexibility

The tannic acid market accommodates buyers across scales with various pricing models. Xian prius lists 95-98% tannic acid at approximately $18-27 per kilogram, with minimum orders starting at 1kg . Shaanxi Laon offers samples at $65/kg for evaluation before bulk commitment . Alibaba listings show ranges from $5-50 per kilogram depending on specifications and volume .

Minimum order quantities typically start at 1kg for commercial extracts, enabling startups and small businesses to access quality materials . Some suppliers accommodate even smaller quantities—100g or 10g—for research and development purposes .

Packaging options include 1kg aluminum foil bags for sample and small orders, progressing to 25kg drums for commercial quantities . Custom packaging accommodates specific requirements.

Supplier Evaluation Best Practices

Successful sourcing from Chinese tannic acid suppliers follows established patterns. Requesting samples enables verification of product characteristics before commitment—most reputable suppliers provide samples, sometimes free with freight collect .

Clear communication about desired specifications, purity levels, certifications, and applications prevents misunderstandings. Response quality and timing often indicate overall professionalism—Sinobio promises reply within 2 hours .

Documentation review remains essential. Comprehensive CoAs should accompany all shipments, providing detailed test results from accredited methods. Suppliers offering third-party verification (SGS, BV) demonstrate commitment to transparency .

Payment terms and logistics require attention, with established suppliers offering various shipping options (DHL, FedEx, UPS, air, sea) and navigating international requirements efficiently .

Market Outlook

The global market for natural polyphenols continues expanding, driven by consumer interest in clean-label ingredients, natural preservatives, and plant-based functional components. Tannic acid's versatility across food, pharmaceutical, cosmetic, and industrial applications positions it favorably for sustained demand.

As research continues clarifying tannic acid's antioxidant, antimicrobial, and therapeutic mechanisms, applications will likely expand. Suppliers investing in rigorous testing, maintaining transparent supply chains, and offering formulation support position themselves advantageously for this growing market.

Final Thoughts

For businesses seeking a versatile natural ingredient with applications spanning food preservation, pharmaceutical formulation, cosmetic development, and industrial processing, China's tannic acid market offers remarkable depth and technical sophistication. The availability of gallnut-derived extracts with verified purity, comprehensive testing, and flexible ordering enables sourcing matched precisely to application requirements.

The concentration of extraction expertise across Hunan, Shaanxi, Jiangxi, and Liaoning provinces creates competitive dynamics benefiting buyers through multiple specification options and service levels. Whether developing functional foods, natural cosmetics, pharmaceutical preparations, or industrial formulations, the landscape of Chinese tannic acid suppliers offers viable options for virtually every business model.

Success depends on thorough due diligence, clear specification communication, and patient relationship building. Suppliers demonstrating consistent quality, transparent practices, and responsive service position themselves as preferred partners as the market for this versatile compound continues its growth trajectory.

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The Current Development Status and Future Development Forecast of the Extract Industry

The extract industry, as a crucial branch of biotechnology, plays a significant role in various sectors including pharmaceuticals, health products, food, and cosmetics. Driven by continuous technological advancement and evolving market demands, the industry is ushering in new development opportunities.

Market Scale and Growth Trends

China has become one of the world’s important producers and consumer markets for extracts. In recent years, the industry scale has continued to expand, maintaining steady growth momentum.

Analysis of Application Fields

Pharmaceutical Field Extracts are widely used in medicine and serve as important raw materials for various drugs. For example, artemisinin extract has shown remarkable efficacy in treating malaria; salvia miltiorrhiza extract is commonly used in cardiovascular disease treatment; and astragalus extract, known for its immune-regulating and antioxidant properties, is widely used in the production of traditional Chinese patent medicines and health products.

Health Products Field With increasing health awareness, the demand for health products is growing. Extracts are favored for their natural origin and diverse health functions, demonstrating clear effects in areas such as enhancing immunity, relieving fatigue, and improving sleep.

Analysis of Competitive Landscape

The current extract industry is highly competitive, presenting a diversified market landscape. Internationally renowned companies hold significant advantages in areas such as R&D, production processes, and quality control, with strong brand influence allowing them to capture a share of the high-end market. Domestic enterprises have developed rapidly in recent years, gradually expanding their market influence by increasing R&D investment, improving efficiency, and optimizing their industrial structure.

Future Development Forecast

(1) Trends in Technological Innovation

Continuous Upgrading of Extraction Technologies Advanced technologies such as supercritical fluid extraction, microwave-assisted extraction, and enzymatic extraction will further enhance extraction efficiency and product quality, enabling more precise separation of components.

Increasingly Sophisticated Component Detection Technologies Analytical methods including high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) will be more widely applied in quality control, allowing for more accurate detection of active ingredients and impurities to ensure product safety and efficacy.

(2) Policy Support and Development Opportunities

Policy Support for the Health Industry Governments worldwide are placing greater emphasis on the health industry. For instance, China has incorporated the development of traditional Chinese medicine into its national strategy, supporting the R&D, production, and international cooperation of TCM extracts, thereby creating a favorable policy environment for the industry.

Consumption Upgrading Driving Demand As living standards improve and consumption concepts evolve, the demand for natural and healthy products continues to rise. The application scope of extracts in fields such as food, health products, and cosmetics is expected to further expand.

(3) Expansion of Application Fields

Agricultural Field Plant extracts can serve as natural pesticides, plant growth regulators, etc., promoting the development of green agriculture. Adding extracts to animal feed can help enhance animal immunity and reduce antibiotic use.

Environmental Protection Field Some extracts possess functions such as antimicrobial and bioremediation, making them applicable in the development of environmentally friendly coatings, soil and water remediation materials, and offering new pathways for environmental management.

Challenges Facing Industry Development

(1) Limitations of Raw Material Resources

The supply of certain plant materials is constrained by growth environments, seasons, and resource conservation policies, leading to insufficient stability. The establishment of large-scale, standardized cultivation bases still requires substantial investment.

(2) Lack of Unified Quality Standard Systems

Discrepancies in quality standards and testing requirements for extracts across different countries increase the difficulty for enterprises in production and export. Establishing internationally recognized quality and testing systems is key to enhancing industry credibility.

(3) Increasingly Fierce Market Competition

As more enterprises enter the industry, competition continues to intensify. Companies need to maintain competitiveness through technological innovation, quality improvement, brand building, and service optimization.

Conclusion

With the expansion of market scale and the broadening of application fields, the extract industry boasts broad prospects. Technological innovation and policy support will continue to inject momentum into the industry. However, challenges such as raw material supply, the establishment of standard systems, and market competition require collaborative efforts from all stakeholders to achieve healthy and sustainable development of the industry.

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Traditional Chinese Medicine and Ayurveda Tribulus Terrestris Extract

Unlock the Benefits of Tribulus Terrestris Extract

Tribulus Terrestris is a plant used a lot in herbal medicine worldwide. It’s called puncture vine and goat’s head too. This plant is big in both Traditional Chinese Medicine and Ayurveda.

It’s known for boosting libido, helping keep hormones in balance, and making athletes perform better. Let’s explore why Tribulus Terrestris benefits are still popular. And why it’s used a lot in natural health supplements.

Introduction to Tribulus Terrestris

Tribulus Terrestris is a well-known plant because of its health benefits. It’s used in traditional medicine around the world. This plant has a long history and special qualities.

Origins and Historical Use

The Tribulus Terrestris origin is found in many places. Some of these are India, China, the southern USA, Mexico, Spain, and Bulgaria. It goes by several names like Gokshur and puncture vine. It is important in Ayurveda and Chinese medicine.

In Ayurveda, it helps with many sexual and urinary issues. In Chinese medicine, it treats eye problems, swelling, and sexual issues.

It is known to increase desire, help with water retention, and reduce inflammation. Research shows it helps with heart, liver diseases, and other conditions.

Botanical Characteristics

The botanical description shows Tribulus Terrestris as a small shrub. It likes dry places. It has many chemical parts like flavonoids and alkaloids. These make it very powerful medicinally.

The plant’s fruits and roots are especially useful. They contain saponins, flavonoids, and other compounds. The saponin part varies by location.

Health Benefits of Tribulus Terrestris Extract

Tribulus Terrestris extract is known for many medicinal benefits. These range from better sexual health to metabolic management. Many studies support the health perks of Tribulus extract, highlighting its effectiveness and safety.

There’s a lot of evidence on the big impact Tribulus Terrestris has on sexual health. One study found that Tribulus, along with other compounds, greatly helped improve erectile function, and overall sexual satisfaction in men facing erectile problems. Another study showed it was more effective than a placebo for erectile dysfunction.

Tribulus Terrestris also helps with metabolic health. A study showed its extract improved blood sugar and cholesterol in diabetic women. After three months, women taking 1,000 mg of Tribulus Terrestris extract daily saw major health improvements.

Muscle strength and body composition improve with Tribulus too. Elite rugby players got stronger and saw better body composition after five weeks of use.

The health benefits of Tribulus extract are significant. However, it’s important to be mindful of possible side effects. Though rare, some people reported kidney issues and stomach problems. Yet, most research finds it safe with few adverse reactions.

Research indicates men with low sex drives saw a 79% increase in desire after taking 750-1,500 mg of Tribulus daily for two months. Also, 67% of women with low libidos felt more desire after 90 days of taking 500-1,500 mg daily.

In conclusion, the medicinal benefits of Tribulus Terrestris extract are vast. It boosts sexual health, metabolic health, and muscle strength. Despite a few possible side effects, its safety and health potential make it a great natural health choice.

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Agaricus blazei extract

Agaricus blazei extract

【Product Name】Agaricus blazei murill Extract

【Extraction site】Fruit body

【Specification】Polysaccharide 10% ~ 50%

【Character】Yellow to yellow brown powder

【Mesh】80 mesh

【Detection method】UV

【Packaging】25 kg/barrel, can be packaged according to customer requirements

【Storage conditions】Sealed away from light, store in a cool, dry, ventilated place

It originated from Brazil, so it is also named the Brazilian mushroom. Its fruit body tastes good, and it is a kind of edible mushroom with high contents of protein and sugar. Every 100 grams of dried mushroom contains 40-45% crude protein, 38-45% sugar, 18.3% amino acids, 5-7% crude ash, 3-4% crude fat. Besides, it also contains vitamin B1, B2. The fruit body contains various active substances which possess the activity of antitumor, cholesterol depressing, blood-glucose depressing, and anti-thrombotic. It can prevent and treat tumors, lower blood sugar, lower blood pressure etc. Agaricus blazei has the function to strengthen the body and has been given much more attention in Japan.

Agaricus blazei polysaccharide

Agaricus blazei polysaccharide mainly contains polysaccharides and ergosterol.The Agaricus blazei polysaccharide which is extracted using hot water has the strong effect to anti-tumor. It can strongly enhance immunity, anti-oxidization, prevent from senility, restrain tumor, increase the patients’ leucocyte number after chemotherapy.

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Panax Notoginseng Saponins (PNS): Clinical Data Summary

Panax notoginseng saponins (PNS) are the primary active components extracted from the root or rhizome of Panax notoginseng (also known as Tianqi or Sanqi), containing various saponins such as ginsenosides Rg1, Rb1, Re, Rd, and notoginsenoside R1. Clinical research has primarily focused on its effects in cardiovascular and cerebrovascular diseases, anti-inflammatory activity, antioxidant properties, and tissue protection. Below is a summary of existing clinical data:

Cardiovascular and Cerebrovascular Diseases

(1) Ischemic Stroke

Clinical Studies:

Multiple randomized controlled trials (RCTs) indicate that PNS (e.g., Xuesaitong Injection or oral formulations) combined with conventional treatment (e.g., aspirin) can improve neurological deficit scores (NIHSS) and daily living ability (Barthel Index) in stroke patients, with significantly higher efficacy than control groups (PMID: 32350721).

Mechanism: Inhibits platelet aggregation, improves microcirculation, and reduces ischemia-reperfusion injury.

(2) Coronary Heart Disease/Angina Pectoris

Meta-analysis (including dozens of RCTs):

PNS injections (e.g., Xueshuantong) can reduce the frequency of angina attacks and improve ECG ST-T segment changes (total effective rate ~70-85% vs. 50-65% in control groups) (PMID: 31568905).

Potential mechanisms include coronary artery dilation and antithrombotic effects.

(3) Recovery After Cerebral Hemorrhage

Small-scale trials suggest PNS may promote hematoma absorption, but more high-quality evidence is needed (controversial).

Antithrombotic and Microcirculation Improvement

Clinical Observations:

PNS inhibits platelet-activating factor (PAF) and thrombin, reducing blood viscosity, and is used for hypercoagulable states or post-surgical thrombosis prevention (some studies show comparable efficacy to low-molecular-weight heparin).

Other Clinical Applications

(1) Diabetic Complications

Adjunctive therapy for diabetic peripheral neuropathy (improving numbness and pain) and retinopathy (delaying microvascular damage).

(2) Anti-inflammatory and Antioxidant Effects

In chronic kidney disease and pulmonary fibrosis, PNS may reduce inflammation by inhibiting the NF-κB pathway (limited clinical data).

(3) Wound Healing

Topical application (e.g., gel formulations) may accelerate wound healing and reduce scarring (supported by animal studies, limited human trials).

Safety Data

Adverse Reactions:

Generally well-tolerated; mild side effects include dizziness, gastrointestinal discomfort, or injection-site pain.

Injections may cause allergic reactions (e.g., rash, dyspnea)—close monitoring required.

Contraindications:

Use with caution in patients with bleeding disorders, perioperative periods, or pregnancy (due to antiplatelet effects).

Controversies and Limitations

Quality of Evidence:

Most studies are from China, with limited international recognition; some trials have small sample sizes or design flaws (e.g., lack of double-blinding).

Unclear Mechanisms:

While in vitro/animal studies suggest multi-target effects, pharmacokinetics and exact mechanisms in humans require further validation.

Preparations and Dosage

Common Products:

Xuesaitong (injection/lyophilized powder), Xueshuantong capsules, Compound Danshen Dripping Pills (containing PNS).

Dosage:

Oral: Typically 100-200 mg/dose, 2-3 times daily; injections require medical supervision.

Conclusion

PNS demonstrates potential efficacy in adjuvant therapy for cardiovascular and cerebrovascular diseases (especially stroke and angina), but more high-quality international multicenter studies are needed. It should be used under medical supervision to avoid bleeding risks when combined with anticoagulants.

Panax notoginseng saponins

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Panax Notoginseng Extract Notoginseng Total Saponins

Notoginseng Total Saponins refers to a group of active compounds extracted from the roots of Panax notoginseng, a plant commonly used in traditional Chinese medicine. Notoginseng, also known as Tienchi ginseng, is valued for its potential health benefits and therapeutic properties.

Radix Notoginseng Extract Notoginseng Total Saponins

English name: Panax Notoginseng Extract,

Other Name: Sanqi, TianQi, Sanchi, Three Seven, Panax pseudoginseng

Specification:

Notoginseng Total Saponins ≥75% HPLC

Ginsenoside Rb1 ≥30%

Ginsenoside Rg1 ≥25%

Notoginsenoside R1≥5%

Ginsenoside Re ≥2.5%

Ginsenoside Rd ≥5%

Notoginseng Powder 100 mesh Pollution-Freee

Description:

off-white to faint yellow amorphous powder, bitter in taste, slightly sweet.

Action:

Reduce the body’s oxygen consumption and improve the body’s tolerance to hypoxia.

Inhibition of platelet aggregation induced by ADP.

Dilated cerebrovascular, Increased cerebral blood flow.

Increase cerebral blood flow.

Antithrombotic and anticoagulant effects.

Packing:

20kg/bag, inner packing is a medical polyethylene bag. outer packing is a cardboard drum.

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Natural Paeonol vs. Synthetic Paeonol: A Complete Guide to Sources, Differences, and Applications

Paeonol is a natural compound with various pharmacological effects, including anti-inflammatory, analgesic, and antioxidant properties. It is widely used in pharmaceuticals, cosmetics, and health supplements. Paeonol can be extracted from plants like tree peony bark (Moutan Cortex) and Cynanchum paniculatum, or synthesized chemically. But what are the key differences between natural and synthetic paeonol? Which one is better for your needs? This article compares them in terms of sources, production methods, purity, cost, and applications.

Sources and Production Methods

(1) Natural Paeonol

Source: Extracted from medicinal plants like peony root bark (Moutan Cortex), Paeonia lactiflora, and Cynanchum paniculatum.

Extraction Process: Uses solvents (ethanol, water), followed by purification steps like column chromatography and crystallization.

Characteristics: Relies on plant cultivation, has a longer production cycle, but aligns with traditional medicine principles.

(2) Synthetic Paeonol

Source: Derived from petrochemical products (e.g., resorcinol, p-hydroxybenzoic acid) via organic synthesis.

Production Process: Chemical reactions (e.g., Friedel-Crafts acylation), followed by purification to obtain high-purity paeonol.

Characteristics: Shorter production time, suitable for large-scale industrial production, and more cost-effective.

✅ Key Difference: Natural paeonol depends on plant resources, while synthetic paeonol relies on chemical synthesis, offering higher efficiency.

Composition and Purity Comparison

AspectNatural PaeonolSynthetic PaeonolMain ComponentsPaeonol + co-extracted compounds (e.g., flavonoids, glycosides)High-purity paeonol (typically ≥98%)ImpuritiesMay contain tannins, pigmentsMay contain synthetic intermediates or catalyst residuesBioactivityMulti-component synergy, gentler effectsSingle compound, precise but may lack synergistic effects

✅ Key Difference: Natural paeonol may offer broader bioactivity, while synthetic paeonol is more standardized for pharmaceutical use.

Cost and Environmental Impact

Natural Paeonol:

Higher cost (due to plant cultivation and extraction inefficiency).

More eco-friendly (but solvent recovery must be managed).

Synthetic Paeonol:

Lower cost (industrial production is more efficient).

Environmental concerns (may involve toxic reagents and waste disposal).

✅ Key Difference: Synthetic paeonol is more economical, but natural paeonol aligns better with green consumer trends.

Applications and Market Acceptance

(1) Pharmaceuticals & Supplements

Natural Paeonol: Preferred in traditional medicine and natural health products.

Synthetic Paeonol: Used in standardized drugs (e.g., anti-inflammatory or cardiovascular medications).

(2) Cosmetics

Natural Paeonol: Used in high-end skincare (marketed as “plant-derived”).

Synthetic Paeonol: Common in mass-market products for anti-allergy and antioxidant benefits.

(3) Regulatory Standards

Natural extracts must comply with heavy metal and pesticide residue limits.

Synthetic versions must meet chemical purity (e.g., ICH guidelines) and solvent residue regulations.

How to Choose?

Choose Natural Paeonol if:

You need traditional medicine formulations, premium cosmetics, or “natural” branding.

Choose Synthetic Paeonol if:

You require high purity, low cost, and large-scale production for pharmaceuticals or cosmetics.

Conclusion

Both natural and synthetic paeonol have pros and cons, and the choice depends on cost, efficacy needs, and market positioning. Natural extracts are ideal for traditional medicine and high-end markets, while synthetic paeonol dominates in standardized drugs and mass-market products. In the future, bio-synthesized paeonol (e.g., microbial fermentation) may emerge as a sustainable alternative!

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Roselle Extract (Hibiscus sabdariffa) – Production, Benefits, and Applications

Roselle Extract Major Producing Countries

Roselle extract is primarily produced in tropical and subtropical regions. The main producing countries and regions include:

Africa

Sudan: One of the world’s largest producers and exporters of roselle, known for high-quality dried calyces and extracts.

Egypt: A traditional growing region, widely used for local consumption and export.

Senegal, Nigeria, Mali: Key producers in West Africa, mainly used in food and traditional medicine.

Asia

China: Cultivated in southern provinces (Guangdong, Guangxi, Fujian, Yunnan), with rapidly growing extract production.

Thailand: Extensively used in beverages and food processing, with significant exports.

India: Grown in southern and central regions for local markets and extract processing.

Latin America

Mexico: A traditional producer, where roselle (locally called “Jamaica”) is used in drinks and medicine.

Brazil: Increasing large-scale production, with some extracts exported.

Other Regions

Malaysia & Philippines: Small-scale cultivation in Southeast Asia, mainly for regional demand.

Extract Processing Countries

Besides raw material production, countries like China, the U.S., and Germany import roselle for advanced processing into high-value extracts (e.g., anthocyanins, organic acids) before re-exporting globally.

Introduction to Roselle Extract

Roselle extract is derived from the flowers of Hibiscus sabdariffa (Malvaceae family). It has various health benefits, including:

Calming liver fire

Reducing inflammation

Quenching thirst

Lowering blood pressure and lipids

Improving mental clarity

Eliminating free radicals

Applications in Food & Beverages

Roselle is a rising ingredient in food industries. Its calyx can be used in:

Jams, candied fruits, high-end beverages

Cold/hot teas, sodas, ice creams, cakes

Canned foods, wines, champagnes

Natural food colorants (vibrant red pigment)

Nutritional supplements (rich in vitamin C for children & elderly)

Active Compounds

Roselle contains:

Proteins, organic acids, vitamin C, amino acids

Natural pigments & minerals

Fresh calyx composition:

Vitamin C (0.93%), Vitamin B (0.21%), protein (0.45%), pectin (1.39%)

Sugars (2.55% as glucose), starch (1.76%), carotenoids (0.01%)

Dried calyx composition:

Anthocyanins (1–1.5%), organic acids (10–15%, e.g., citric & hibiscus acids)

Reducing sugars (16%), fiber (11%), 17 amino acids (~1%)

Additional bioactive compounds:

Flavonoids, glycosides, phenols, alkaloids, resins

Health Benefits & Nutritional Value

Roselle is rich in antioxidants (vitamin C & anthocyanins), which combat free radicals, slow aging, and boost immunity.

Key Findings (2024 Studies)

Cardiovascular Health: Anthocyanins help lower blood pressure, especially in hypertensive patients.

Liver Protection: Extracts enhance detoxification and repair damaged liver cells.

Diabetes Management: Regular consumption stabilizes blood sugar levels.

Extraction Methods

Water extraction (cost-effective for polysaccharides & alkaloids)

Ultrasonic extraction (efficient for large-scale production)

Microwave extraction (preserves bioactive compounds)

Pharmacological Effects of Roselle

Modern research highlights its bioactive components:

Phenolic acids (e.g., protocatechuic acid)

Flavonoids (e.g., hibiscetin, quercetin)

Anthocyanins (e.g., delphinidin-3-sambubioside, cyanidin-3-sambubioside)

Organic acids (e.g., citric, hibiscus, tartaric acids)

Proven Benefits

Antihypertensive Effects

A 4-week trial (39 patients) showed reduced systolic BP (139.05 → 123.73 mmHg) and diastolic BP (90.81 → 79.52 mmHg).

Mechanism: Vasodilation + ACE inhibition via anthocyanins.

Antidiabetic Effects

A 14-day study (diabetic women) found lowered fasting glucose (111.25 → 88.58 mg/dL) due to flavonoid-induced enzyme inhibition.

Lipid Reduction

Roselle powder decreased cholesterol, triglycerides, and LDL in obese subjects.

Kidney Protection

28-day consumption reduced creatinine, uric acid, and albuminuria in diabetic nephropathy patients.

Hibiscus sabdariffa, Roselle Extract

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Stachyose

Description: Stachyose is a white powdery product made from stachys affinis (also known as Chinese artichoke and crosne) by cleaning, slicing, extracting, filtering, concentrating, drying, pulverizing, sieving and packing.

CAS Number: 10094-58-3

Molecular Formula：C24H42O21

Molecular Weight：666.59

Product specifications：60%,70%,80% HPLC

Source: Stachys sieboldii, Stachys floridana

Form: white or light yellow powder, no smell

Solubility：≧98%

Taste: slightly sweet, 22% of sucrose

Viscosity: higher than sucrose, lower than malt syrup

Application: It is widely used in medicine, food, dairies, beverages and other fields.

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Bromelain 200gdu/g to 2400gdu/g pineapple stem

Bromelain, also known as pineapple protease, is extracted from pineapple stem, pericarp etc. it’s a pure natural protease after biotechnology, its molecular weight is 33000, isoelectric point is 9.55. It belongs to –SH protease with pineapple odor, can proceed protein hydrolyze and other biochemical reaction. Bromelain can widely apply on food, Cosmetic, Pharmaceutical and other industry. Our bromelain can reach pharma and food grade demand.

Bromelain Activity:

The activity is from 200gdu/g to 2400gdu/g, we can supply formulations according to customer requirement.

Application area

Food processing industry: add the bromelain to the dough to degrade the gluten and soften the dough, can congeal the casein for cheese, tenderize the meat, increase bean cake and bean flour PDI value and NSI value, then produce soluble protein product and grain food and beverage,

Cosmetic industry area: The bromelain has the ability of tender-skin, Whitening and Freckle-removing effect. Prompt the skin’s metabolism, relieve the skin become dark that cause by sunshine. Keep the skin white and tender

Pharmaceutical and health care industry：Restrain tumour cells growing，Prevent the cause of cardiovascular disease，Apply to treat the skin burn crust，Apply to diminish inflammation，Assist absorb of pharmaceutical

Feed industry: Add the bromelain to the feed can highly improve protein utilization and transformation rate, and also develop more protein source, that finally reduce the cost of feed.

Suggested use condition:

Reaction temperature:30-45℃；reaction PH value is 6-6.8.

(Can adjust the temperature and PH value according to the kind and concentration of the substrate)

Dosage: 0.1%-0.5%.

Matters needed attention:

Bromelain is a bioactivity material, can easily be inhibited and destroyed by oxidant and heavy metal ion（ Fe 3+ 、 Cu 2+ 、 Hg + 、 Pb + etc.）should avoid with its contacting. Bromelain is a sensitization source, absorb bromelain will lead to allergy, but oral absorb can not cause allergy, so should strictly avoid absorbing enzyme powder.

Storage condition:

Store in low temperature（4℃）in cold storage or dry place avoiding sunlight.

[qualityherb]

Black Tea Extract 40% 80% Tea Theaflavins

Black Tea Extract 40% 80% Tea Theaflavins https://www.qherb.net/

BlackTeaExtract #Theaflavins #TeaExtract #BlackTea #Antioxidants #Polyphenols #TeaFlavonoids #HealthBenefits #NaturalTea #OrganicTea #TeaSupplement #TheaflavinsBenefits #TeaCompounds #TeaBioactives #HerbalSupplements #HealthyLiving #ImmuneSupport #TeaLovers #TeaForHealth #TeaScience #DetoxTea #TeaAntioxidants

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Konjac Root Extract Powder Konjac Glucomannan

Konjac Root Extract Powder Konjac Glucomannan Latin Name: Anorphophallus konjac K Koch Active ingredient: Glucomannan CAS No.: 37220-17-0 Molecular Formula: C26H43O22 Molecular Weight: 780 Specificatin: 60%~95% Glucomannan Appearance: White fine powder

Introduce:

50% to 60% glucomannan, 20% to 30% starch, 5% cellulose, 5% to 10% crude fat, 3-5% soluble sugar (monosaccharide and oligosaccharide), and 3-5% ashy materials (mineral elements) are all present in dry konjac.

According to both domestic and international studies, konjac glucomannan is a polysaccharide that is joined by many β-1-4 glycosidic links with D-glucose and D-mannose at a gramme molecular ratio of 1:1.6. Its molecular weight ranges from one million to two million daltons.

A naturally occurring dietary fiber with a large molecular weight and exceptionally high viscosity, konjac glucomannan may retain up to 200 times its original volume of water and transform it into a viscous liquid. Due to the unique β-1-4 linked structure of D-glucose and D-mannose, Konjac glucomannan does not supply calories and is not impacted by human digestive enzymes.

The food, beverage, health care, pet food, and chemical sectors all make extensive use of konjac glucomannan as a gelling agent, thickening, stabilizer, emulsifier, and film forming.

Common Konjac Glucomannan  Property:

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Yohimbe Bark Extract 

Yohimbe Bark Extract 

Botanical Source: Pausinystalia Yohimbe

Part Used: Bark

Appearance: Red-brown to white fine powder

Specifications: 8%-98% Yohimbine HPLC

CAS NO.: 523-06-8

Description:

The origin of yohimbine is Africa. The active ingredient of Yohimbe is yohimbine, which is widely used for curing sexual dysfunction that results from tension, pressure, and fatigue. Meanwhile, it could also increase the strain of sexual muscle, providing urine repressing function with no damnification. In addition, it could speed the body’s energy circulation to increase the energy supply. It is mainly used as the raw nourishment material to improve sexual performance.

[qualityherb]

Gardenia Extract

Gardenia Extract

Botanical Source: Gardenia jasminoides Ellis Part used: Fruit

Active ingredients: Crocin, Geniposide, Genipin, Gardenia Yellow, Gardenia Blue, Gardenia Green

Specifications:

Geniposide 10%- 98% HPLC

Crocin 50%

Crocetin 70%

Introduction:

Fructus Gardenia, the dried ripe fruit of Gardenia jasminoides Ellis (Rubiaceae), is widely used in traditional medicine for its cholagogue, sedative, diuretic, antiphlogistic, and antipyretic effects. Additionally, it is an externally used drug with a long heritage and tradition in the treatment of sprain. Many iridoid glycosides were isolated from Gardeniae Fructus in previous investigations, including Geniposide.