Generic/Unknown/Fictional Poison Treatments
Whether youāre a writer trying to avoid getting yourself put on a watchlist, medically inclined or just curious, these are the general steps we as veterinarians would take with a poisoning or toxicity case when we donāt know exactly what weāre dealing with, including a completely hypothetical made up poison.
What you do first depends on what state the patient is in.
Are they conscious and what are their vital signs?
What symptoms do they have?
Have they eaten the poison, or been exposed to a toxin some other way?
Treat the urgent problems
Treat the symptom most likely to result in death first. Trouble breathing? Control the airway. Irregular heartbeat? Get an intravenous line in and start symptomatic treatment. Seizures? Medicate them. The aim is to just make them ānot deadā in the next fifteen minutes so you can figure everything else out.
If they present without an urgent problem, so before they have symptoms, then move on to decontamination.
How did the patient come into contact with the poison or toxin?
Did they eat it, if so can we make them vomit? Is it safe to do so (able to swallow, toxin does not release gas, isnāt corrosive), if not, stomach pump time, +/- enema. (some toxins, like snail bait, speed up the gut transit time so the poison is often sitting in the large bowel by the time symptoms set in)
Is it on them somehow? Rinse, dissolve or otherwise remove from their skin.
Is it injected? Well, weāre going to have to do this the hard way.
So, patient is currently alive and not at immediate risk of dying in the next 20 minutes (hopefully), but still poisoned, and we want to clear that.
Most patients will have a perfectly decent liver and pair of kidneys to do most of the work for us, but we can help them along in a hospital setting. There are a few possible pathways any given toxin can take to be rendered harmless or to leave the body:
It can be metabolised. Be wary though, some toxins, like antifreeze, are actually metabolised into more toxic compounds before they are rendered harmless.
It can be excreted in urine. Unfortunately, some of these toxins can also be re-absorbed from the bladder.
It can be excreted in bile, enter the gastrointestinal tract and leave the body in the stool. But, many of these can also be re-absorbed from the gastrointestinal tract too.
So, how do we support these functions?
First, give an antidote if you have access to one. But with an unknown toxin, you probably donāt.
Intravenous fluids. The liver and kidney both like lots of fluid to work with, so we make sure they have enough, but not too much. This also helps dilute any toxin inside the kidney, reducing the damage it might do, and speeds up renal clearance.
You can couple this with a urinary catheter to drain urine immediately instead of letting it sit in the bladder, where it may be reabsorbed. We sometimes do this in a severe chocolate toxicity.
Oral activated charcoal. Whether itās fed or administered by some sort of stomach tube, flooding the gut with activated charcoal absorbs most organic toxins (those with chains of multiple carbon atoms) and prevents them being absorbed. It wont work for very small molecules or heavy metals, but itās a fair guess for a lot of unknown toxins.
Laxatives. Activated charcoal is often paired with a laxative, so that gut contents contaminated with the toxin arenāt sitting in the intestine any longer than they have to be.
And then, if weāre still going, things start to get a bit more involved.
That hardworking liver may well benefit from a collection of antioxidants and amino acids if itās having a hard time. It uses those molecules to bind to all sorts of toxins and their breakdown products, and if itās running out you can supplement many of them. Some can be given intravenously, some orally. SAMe is used a lot for just genetic āgive the liver a little helpā purposes.
Some toxins bind to fat, which is a problem because the brain is mostly fat, and they donāt dissolve into the water of the blood to be cleared very easily. So we may use an intravenous fat infusion, usually used for nutrition, to help make the toxin accessible and clear it. Thereās already plenty of water and protein in the blood, but not much fat except for immediately after a meal.
And while you are decontaminating and clearing the patient, you need to maintain symptomatic control. That is basically using whatever works to control any symptoms the poison or toxin is producing, as they happen. Thatās the basic ākeep it aliveā side of treatment while decontamination and clearing is the āactually treat the problemā side.
And with a bit of luck, some good equipment and a bunch of skill, you can keep them alive long enough to figure out whatās going on.