Syme and Parsons both asked Winston for razor blades. Winston had some razor blades hoarded up, but I believe it’s mentioned in the book at some point that they were particularly short on razor blades in Airstrip One in general.
Now, Syme, Parsons, Winston, Julia, Ampleforth, and many others all canonically got the axe by the end of the book. That is a LOT of people all from the same building who died. The events of the book all take place within a few months if I remember correctly— excluding, of course, all of the flashbacks to Winston’s childhood and marriage. So that is at least five people from the same general section who have been unpersoned within a few months. A bit odd, don’t you think?
Also remember that Winston was thinking of ways to kill himself to escape torture in Part One, after he gets the diary; the most viable way for one to kill himself is with a razor blade.
Syme was also working on the Eleventh Edition of Newspeak, and comments that eventually no one will be speaking the same language they are now.
Katharine, Winston’s wife, is proof that if a Party member wishes to engage in sex, it must be without pleasure, and with the goal of producing offspring. Enter the Anti-Sex League. Enter ARTSEM (artificial insemination).
Enter the massive change of Eurasia to Eastasia that everyone had to work on like maniacs.
I think every time the Party makes some major change to the language and political climate, they recognize that in order to maintain a new lie, they have to get rid of the evidence. So they manufacture a shortage of razor blades so that no one can kill themselves and force everyone living to work on changing the past and birthing children before they kill off whoever they need to kill to maintain the lie and the population.
After they didn’t need Syme for the language anymore, they discarded him. They still needed Parsons and Winston for Hate Week and to change the records; but AS SOON AS THEY WERE FINISHED, they were shipped off to Miniluv. They may have needed Julia as an extra hand in fiction to produce more materials to distract the proles from all the giant changes, and discarded her after she had made sufficient pornography to do that.
The Party is like a rocket ship; it detonated in stages.
This point is further proven by O’Brien’s dialogue:
“Your kind is extinct. We are the inheritors.”