Untitled

[stephypublishers]

Maternal and Neonatal Idiopathic Thrombocytopenic Purpura Immune thromb

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

ocytopenic (ITP) is an autoimmune disease that affects 9.5/100,000 adults in the population.1 It is characterized by autoimmune destruction of platelets leading to potentially life-threatening thrombocytopenia. About 7% of pregnant mothers are affected by thrombocytopenia with 1 to 10 per 10,000 mothers being affected with ITP. Studies have shown that ITP is generally a benign condition in the birthing mother and rarely has a long-lasting effect on the newborn child.2 In the rare event that the newborn is severely affected, treatment is required. We present a case of ITP in both a mother and her newborn.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000504.pdf

[stephypublishers]

Evaluation of Serum Tumor Markers Variation, following the Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

45 cases of female patients aged 16-60 years with thyroid cancer surgery referred to the nuclear medicine department of Nemazi hospital for (iodine treatment after surgery) were selected. The selection was on the basis of interviewing and information of patients is consent forms. Only patients with thyroid cancer and referred for the first time without any other diseases were chosen for this study. The selected patients were prescribed a dose of 150mCi of I-131.From each patient, 4 mL of chelated serum for serological studies on tumor markers and 2 mL of oxalated serum for spectrophotometry studies on cell death were used in three stages. The first stage before the iodine therapy, the second stage, after 48 hours, and the third stage, 30 days after radioiodine therapy were studied and the results were evaluated by the one-way repeated measures ANOVA test.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000503.pdf

[stephypublishers]

Evaluation of Arterial Hypertension Care in Four Brazilian Metropoles

Stephy Publishers

Journal of Cardiology and Current Trends in Surger

Hypertension (AH) is one of the most prevalent chronic diseases in Brazil, which, in 2018, affected about 24.5% of the adult population, reaching 59.3% of people aged 65 and over. (Ministry of Health 2020)  These levels of prevalence and with an increasing trend have a major impact on morbidity and mortality, with high social cost. In this context, the Unified Health System (SUS) has been developing a strategic action plan based on conceptual bases that involve a comprehensive approach to chronic non-communicable diseases, especially AH, at all levels of activity (promotion, prevention and comprehensive care and Organization health services for the care of patients with chronic diseases). The guidelines of the Strategic Action Plan recommend that the care offered should use, in addition to pharmacological Therapy, educational actions to change lifestyle (encouraging the practice of physical activity, the consumption of healthy foods and the reduction of salt consumption),  monitoring the disease by means of routine examinations and searching for damage to a target organ (ECG and Echo cardiogram) in specific populations.

https://www.stephypublishers.com/cardiology-and-current-trends-in-surgery/pdf/JCCTS.MS.ID.000502.pdf

[stephypublishers]

The Diabetic Foot: New Challenges in Management and Care

Stephy Publishers

Journal of Cardiology and Current Trends in Surgery

Early diagnosis of diabetic polyneuropathy (DPN) is important for several reasons. First, careful and regular medical follow-up should be offered to avoid neuropathic DFUs. Secondly, optimised glycaemic control and correction of other vascular risk factors (e.g. hypertension, dyslipidaemia etc) should be diligently pursued. Finally, daily foot hygiene and appropriate footwear are indispensable. A number of practical bedside clinical tools contribute to improved early diagnosis, such as the indicator test Neuropad assessing sweat production in the feet, Vibra Tip, the portable NC-stat DPN Check device and others. Neuropad has been extensively studied and confirmed as an excellent, highly reproducible and practical screening tool with very high sensitivity and negative predictive value for DPN, which renders itself even for patient self-examination. Vibra Tip is a pocket-sized portable device which measures vibration perception at the hallux, whose diagnostic utility has recently been confirmed. NC-stat DPN Check is a special device for automated nerve conduction study of the sural nerve, which may be used by all health care professional after minimal training. We have shown that it yields very high diagnostic performance (sensitivity, specificity, positive and negative predictive value) in both diabetes types.

https://www.stephypublishers.com/cardiology-and-current-trends-in-surgery/pdf/JCCTS.MS.ID.000501.pdf  

[stephypublishers]

Lately Performed Arterial Switch Operation in a Three Years Old Child Diagnosed of Transposition of Great Arteries

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

The Patient with the symptom of severe syanosis from birth have been diagnosed as TGA, VSD and ASD with pediatric cardiology examination in an extarnal hospital. After a withut follow-up period; when 34 months age the patient applicated to our institute hospital by the complains of severe synosis and reduction of effort capacity. According to ecocardiography and angiograghy findings, Arterial switch operation(AS) planned and performed even late age of patient.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000502.pdf

[stephypublishers]

Formulation, Development and Evaluation of Fast Disintegrating Piroxicam Tablets

Stephy Publishers

International Journal of Pharmaceutical Sciences - (IJPS)

Piroxicam is a non-steroidal anti-inflammatory drug used in the treatment of osteo arthritis, rheumatoid arthritis, ankylosing spondylitis, classified in the Bio pharmaceutics Drug Classification system as a Class II drug because it has low solubility and high permeability. It demonstrates a slow and gradual absorption via the oral route and has a long half-life of elimination, rendering a prolonged therapeutic action and a delayed onset of anti-inflammatory and analgesic effect. Thus an attempt is made to formulate piroxicam fast disintegrating tablet so that it helps to render faster onset of anti inflammatory and analgesic effect. To increase the solubility of piroxicam solid dispersion method is opted in the present investigation. Study proposes the use of PVPk30 to prepare solid dispersion of piroxicam and comparison of its invitro dissolution with pure piroxicam. Fast Dissolving tablets can be prepared by conventional direct compression method using solid dispersion. For better Hardness, less friability, faster wetting time and less moisture uptake combination of both MCC and Mannitol are used in the formulation.

https://www.stephypublishers.com/international-journal-of-pharmaceutical-sciences/pdf/IJPS.MS.ID.000501.pdf

[stephypublishers]

Triple Umbilical Incision for Videlaparoscopic Cholecystectomy

Stephy Publishers

Open Access Journal of General Surgery

Triple Umbilical Incision for Videlaparoscopic Cholecystectomy

The laparoscopic surgery is done by using a single port. You place a device through a single incision between 18mm to 50mm and 3-4 trocars can be used. Our work consists of making 3 little incisions to put the three trocars which measure 5 mm and use conventional instruments that measure 36 cm of length of laparoscopic surgery within the internal limits of the umbilicus. Describe the surgery technique and evaluate the initial results of a laparoscopic cholecystectomy option through three intraumbilical incisions. It is a retrospective, descriptive, multicentre and observational study. Since June 2014 to August 2019, 20 patients, 17 females and 3 males, were operated using this method from the age ranges of 16 to 65 years old. The average surgical time was 65 minutes. In all cases the procedures were concluded by the intraumbilical approach. One of the cases had to be re-operated due to intraabdominal bleeding from the posterior branch of the cystic artery. The technique is reproducible; the usual triangulation of the ports is not available. Therefore, fort this technique the surgeon needs to have experience and have had advanced training in laparoscopic surgery. The cases must be selective.

https://www.stephypublishers.com/general-surgery/pdf/OJGS.MS.ID.000501.pdf

[stephypublishers]

Comparative Study of Two Nebulized Preparations of Salbutamol in Children

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

We conducted a prospective double blind randomized trial between April and December 2017 in which 30 children with asthma were included. Children were assigned randomly to receive nebulized Asthalin® or Ventolin®, with 15 patients included in each study arm. For each patient, oxygen saturation, presence of wheezing, retractions and thoraco-abdominal asynchrony, before and after Salbutamol nebulization were recorded. The effect of each treatment dose on oxygen saturation and respiratory rate after stratification of the initial population was analyzed.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000501.pdf

[stephypublishers]

Maternal and Neonatal Idiopathic Thrombocytopenic Purpura Immune thromb

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

ocytopenic (ITP) is an autoimmune disease that affects 9.5/100,000 adults in the population.1 It is characterized by autoimmune destruction of platelets leading to potentially life-threatening thrombocytopenia. About 7% of pregnant mothers are affected by thrombocytopenia with 1 to 10 per 10,000 mothers being affected with ITP. Studies have shown that ITP is generally a benign condition in the birthing mother and rarely has a long-lasting effect on the newborn child.2 In the rare event that the newborn is severely affected, treatment is required. We present a case of ITP in both a mother and her newborn.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000504.pdf

[stephypublishers]

Evaluation of Serum Tumor Markers Variation, following the Radioactive Iodine Therapy in Patients with Differentiated Thyroid Cancer

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

45 cases of female patients aged 16-60 years with thyroid cancer surgery referred to the nuclear medicine department of Nemazi hospital for (iodine treatment after surgery) were selected. The selection was on the basis of interviewing and information of patients is consent forms. Only patients with thyroid cancer and referred for the first time without any other diseases were chosen for this study. The selected patients were prescribed a dose of 150mCi of I-131.From each patient, 4 mL of chelated serum for serological studies on tumor markers and 2 mL of oxalated serum for spectrophotometry studies on cell death were used in three stages. The first stage before the iodine therapy, the second stage, after 48 hours, and the third stage, 30 days after radioiodine therapy were studied and the results were evaluated by the one-way repeated measures ANOVA test.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000503.pdf

[stephypublishers]

Evaluation of Arterial Hypertension Care in Four Brazilian Metropoles

Stephy Publishers

Journal of Cardiology and Current Trends in Surger

Hypertension (AH) is one of the most prevalent chronic diseases in Brazil, which, in 2018, affected about 24.5% of the adult population, reaching 59.3% of people aged 65 and over. (Ministry of Health 2020)  These levels of prevalence and with an increasing trend have a major impact on morbidity and mortality, with high social cost. In this context, the Unified Health System (SUS) has been developing a strategic action plan based on conceptual bases that involve a comprehensive approach to chronic non-communicable diseases, especially AH, at all levels of activity (promotion, prevention and comprehensive care and Organization health services for the care of patients with chronic diseases). The guidelines of the Strategic Action Plan recommend that the care offered should use, in addition to pharmacological Therapy, educational actions to change lifestyle (encouraging the practice of physical activity, the consumption of healthy foods and the reduction of salt consumption),  monitoring the disease by means of routine examinations and searching for damage to a target organ (ECG and Echo cardiogram) in specific populations.

https://www.stephypublishers.com/cardiology-and-current-trends-in-surgery/pdf/JCCTS.MS.ID.000502.pdf

[stephypublishers]

The Diabetic Foot: New Challenges in Management and Care

Stephy Publishers

Journal of Cardiology and Current Trends in Surgery

Early diagnosis of diabetic polyneuropathy (DPN) is important for several reasons. First, careful and regular medical follow-up should be offered to avoid neuropathic DFUs. Secondly, optimised glycaemic control and correction of other vascular risk factors (e.g. hypertension, dyslipidaemia etc) should be diligently pursued. Finally, daily foot hygiene and appropriate footwear are indispensable. A number of practical bedside clinical tools contribute to improved early diagnosis, such as the indicator test Neuropad assessing sweat production in the feet, Vibra Tip, the portable NC-stat DPN Check device and others. Neuropad has been extensively studied and confirmed as an excellent, highly reproducible and practical screening tool with very high sensitivity and negative predictive value for DPN, which renders itself even for patient self-examination. Vibra Tip is a pocket-sized portable device which measures vibration perception at the hallux, whose diagnostic utility has recently been confirmed. NC-stat DPN Check is a special device for automated nerve conduction study of the sural nerve, which may be used by all health care professional after minimal training. We have shown that it yields very high diagnostic performance (sensitivity, specificity, positive and negative predictive value) in both diabetes types.

https://www.stephypublishers.com/cardiology-and-current-trends-in-surgery/pdf/JCCTS.MS.ID.000501.pdf  

[stephypublishers]

Lately Performed Arterial Switch Operation in a Three Years Old Child Diagnosed of Transposition of Great Arteries

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

The Patient with the symptom of severe syanosis from birth have been diagnosed as TGA, VSD and ASD with pediatric cardiology examination in an extarnal hospital. After a withut follow-up period; when 34 months age the patient applicated to our institute hospital by the complains of severe synosis and reduction of effort capacity. According to ecocardiography and angiograghy findings, Arterial switch operation(AS) planned and performed even late age of patient.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000502.pdf

[stephypublishers]

Formulation, Development and Evaluation of Fast Disintegrating Piroxicam Tablets

Stephy Publishers

International Journal of Pharmaceutical Sciences - (IJPS)

Piroxicam is a non-steroidal anti-inflammatory drug used in the treatment of osteo arthritis, rheumatoid arthritis, ankylosing spondylitis, classified in the Bio pharmaceutics Drug Classification system as a Class II drug because it has low solubility and high permeability. It demonstrates a slow and gradual absorption via the oral route and has a long half-life of elimination, rendering a prolonged therapeutic action and a delayed onset of anti-inflammatory and analgesic effect. Thus an attempt is made to formulate piroxicam fast disintegrating tablet so that it helps to render faster onset of anti inflammatory and analgesic effect. To increase the solubility of piroxicam solid dispersion method is opted in the present investigation. Study proposes the use of PVPk30 to prepare solid dispersion of piroxicam and comparison of its invitro dissolution with pure piroxicam. Fast Dissolving tablets can be prepared by conventional direct compression method using solid dispersion. For better Hardness, less friability, faster wetting time and less moisture uptake combination of both MCC and Mannitol are used in the formulation.

https://www.stephypublishers.com/international-journal-of-pharmaceutical-sciences/pdf/IJPS.MS.ID.000501.pdf

[stephypublishers]

Comparative Study of Two Nebulized Preparations of Salbutamol in Children

Stephy Publishers

Journal of Pediatrics and Clinical Neonatology - (JPCN)

We conducted a prospective double blind randomized trial between April and December 2017 in which 30 children with asthma were included. Children were assigned randomly to receive nebulized Asthalin® or Ventolin®, with 15 patients included in each study arm. For each patient, oxygen saturation, presence of wheezing, retractions and thoraco-abdominal asynchrony, before and after Salbutamol nebulization were recorded. The effect of each treatment dose on oxygen saturation and respiratory rate after stratification of the initial population was analyzed.

https://www.stephypublishers.com/pediatrics-and-neonatology/pdf/JPCN.MS.ID.000501.pdf

[stephypublishers]

Triple Umbilical Incision for Videlaparoscopic Cholecystectomy

Stephy Publishers

Open Access Journal of General Surgery

Triple Umbilical Incision for Videlaparoscopic Cholecystectomy

The laparoscopic surgery is done by using a single port. You place a device through a single incision between 18mm to 50mm and 3-4 trocars can be used. Our work consists of making 3 little incisions to put the three trocars which measure 5 mm and use conventional instruments that measure 36 cm of length of laparoscopic surgery within the internal limits of the umbilicus. Describe the surgery technique and evaluate the initial results of a laparoscopic cholecystectomy option through three intraumbilical incisions. It is a retrospective, descriptive, multicentre and observational study. Since June 2014 to August 2019, 20 patients, 17 females and 3 males, were operated using this method from the age ranges of 16 to 65 years old. The average surgical time was 65 minutes. In all cases the procedures were concluded by the intraumbilical approach. One of the cases had to be re-operated due to intraabdominal bleeding from the posterior branch of the cystic artery. The technique is reproducible; the usual triangulation of the ports is not available. Therefore, fort this technique the surgeon needs to have experience and have had advanced training in laparoscopic surgery. The cases must be selective.

https://www.stephypublishers.com/general-surgery/pdf/OJGS.MS.ID.000501.pdf