#595-33-5

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How dose Megestrol acetate works?

　　Megestrol acetate (CAS.NO:595-33-5), also known as 17α-acetoxy-6-dehydro-6-methylprogesterone, and sometimes abbreviated as MGA or MA, is a steroidal progestin and progesterone derivative (specifically, a 17-hydroxylated progesterone) with predominantly progestational and antigonadotropic effects.    Megestrol is a type of hormone therapy. Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues.(For example, the hormone testosterone made in the testicles is responsible for male characteristics such as deepening voice and increased body hair). The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells.Hormone therapies work by; stopping the production of a certain hormone, blocking hormone receptors, or substituting chemically similar agents for the active hormone, which cannot be used by the tumor cell.The different types of hormone therapies are categorized by their function and/or the type of hormone that is effected.

　　Megestrol is a progestin (a man-made form of the hormone progesterone).It has properties that interfere with the normal estrogen cycle.This interferes with the stimulation of cell growth in estrogen dependent tumor cells.  There is also thought to be some direct effect on the lining of the uterine wall (endometrium).

　　A side effect of megestrol has been weight gain.The exact mechanism of this effect is unclear, however the effects lead to an increase in body fat.Taking advantage of this side effect, megestrol has been studied and used to treat severe appetite loss (anorexia), muscle wasting (cachexia) and weight loss associated with cancer and AIDS.

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Why has veterinarian prescribed Megestrol Acetate on animals?

　　Megestrol acetate(CAS.NO 595-33-5) is used to postpone estrus and alleviate false pregnancy. It may be used in cats to treat behavior problems (e.g. inter-male aggressive behavior, urine spraying, aggression towards people). It has also been used to treat a variety of skin conditions.

　　How do you give this medication? 　　*Give this medicine to your pet as directed by your veterinarian. READ THE LABEL CAREFULLY. 　　*If the medicine is a liquid, measure the dose with reasonable care. 　　*Try to give this medication at about the same time each day. 　　*DO NOT give your pet more medicine than directed and DO NOT give the drug more often than directed 　　*DO NOT stop giving this medication to your pet unless directed by your veterinarian. 　　*Try not to miss giving any doses. 　　What if I miss giving a dose? 　　Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule. Do not give the pet two doses at once. 　　How do I store this medicine? 　　*Keep this medicine out of reach of children 　　*Store this medicine in a cool, dry place at room temperature. 　　*Do not store this medicine in the bathroom, near the kitchen sink or in damp places. The medicine may break down if exposed to heat or moisture. 　　What are the potential side effects? 　　*The following side effects have been reported: excessive thirst, excessive urination, personality changes, drowsiness, and increased weight. In dogs, changes in hair color may occur. 　　*Notify your veterinarian if mammary changes or if side effects are noted. 　　*Other side effects may occur. If the pet experiences anything unusual, contact your veterinarian.

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What is the side effect and precautions of Megestrol Acetate?

　　Megestrol acetate (CAS.NO 595-33-5) belongs to category f progestogen analogue drugs. Megace is an oral suspension that contains megestrol acetate, a synthetic derivative of the naturally occurring steroid hormone, progesterone. Progestogens are largely used as second or third line therapy in conditions such as cachexia, weight loss (as in HIV/AIDS), breast cancer and endometrial cancer.　　 　　What are the possible side effects of megestrol acetate? 　　Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. 　　Call your doctor at once if you have a serious side effect such as: *high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss); *nausea, vomiting, dizziness, weakness, or feeling like you might pass out; *sudden numbness or weakness, especially on one side of the body; *chest pain, sudden cough, wheezing, rapid breathing, fast heart rate; or *high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion). 　　Less serious side effects may include: *upset stomach; *vaginal bleeding; *mild skin rash; *weakness, *sleep problems (insomnia); or *decreased interest in sex, impotence, trouble having an orgasm. 　　Precautions: Before taking megestrol, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. 　　Before using this medication, tell your doctor or pharmacist your medical history, especially of: adrenal gland problems (e.g., Cushing's syndrome), blood clots, congestive heart failure, diabetes, high blood pressure, kidney problems, unusual vaginal bleeding. 　　High blood sugar (hyperglycemia) and worsening of diabetes may occur. Symptoms of high blood sugar include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor immediately. People with diabetes should monitor their blood sugar levels more frequently when they start taking this medication and whenever the dose changes since they may need to change their doses of diabetic medications. 　　This drug may decrease adrenal gland activity. Make sure you tell your doctors and dentists of your megestrol use and when you stopped using it. After stopping this drug, additional corticosteroids (e.g., prednisone or hydrocortisone) may be necessary in stressful situations such as trauma, major surgery or serious infection. Consult your doctor or pharmacist for details. Symptoms of adrenal problems include unusual weakness, dizziness, nausea and rapid weight loss. 　　Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug and to its side effects. 　　This medication must not be used during pregnancy. Megestrol acetate may cause harm to your unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately. Women of childbearing age should use an effective form of birth control while using this medication. Consult your doctor for more details. 　　Megestrol may pass into breast milk and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.