Jul 30, 2025
Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life - New Study
Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life Summary Delivering broadly neutralizing antibodies (bNAbs) against HIV-1 via adeno-associated virus (AAV) vectors in early life holds promise for HIV prevention. Success hinges on several factors: vector design (serotype, promoter choice, and transgene codon optimization impact expression), host factors (immune…