#acute heart attacks

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Enrollment Completed in Phase 2 ALLSTAR Cardiac Clinical Trial

Enrollment Completed in Phase 2 ALLSTAR Cardiac Clinical Trial

Capricor Therapeutics Inc. has announced the completion of patient enrollment in their Phase 2 ALLSTAR clinical trial.  ALLSTAR stands for ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration, and this trial will test Capricor’s CAP-1002 product in patients suffering from cardiac dysfunction following a heart attack. CAP-1002 cells are cardiosphere derived cells (CDCs) that were…

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Adult Directly Reprogrammed With Proteins into Cardiac Progenitor Cells Heal Heart After a Heart Attack and Make New Heart Muscle

Adult Directly Reprogrammed With Proteins into Cardiac Progenitor Cells Heal Heart After a Heart Attack and Make New Heart Muscle

Jianjun Wang from Wayne State School of Medicine in Detroit, Michigan and Xi-Yong Yu from Guangzhou Medical University and a host of graduate students and postdoctoral research fellows in their two laboratories have teamed up to make human cardiac progenitor cells (CPCs) from human skin fibroblasts through direct reprogramming. Direct reprogramming does not go through a pluripotent intermediate,…

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Combining Umbilical Cord Cells with Hyaluronic Acid Improves Heart Repair After a Heart Attack

Combining Umbilical Cord Cells with Hyaluronic Acid Improves Heart Repair After a Heart Attack

Umbilical cord blood cells have an advantage over bone marrow or peripheral blood cells in that aging, systemic inflammation, and stress or damage caused by cell processing procedures can potentially compromise and diminish the regenerative capability of these cells. This problem is particularly acute in the case of treating patients who have recently suffered a heart attack, since transplanted…

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Umbilical Cord Stem Cells Improve Heart Function after a Heart Attack

Umbilical Cord Stem Cells Improve Heart Function after a Heart Attack

The umbilical cord connects the baby to the placenta and contains umbilical arteries, umbilical veins, and a gooey material between the umbilical vessels called Warton’s jelly. Warton’s Jelly (WJ), besides being rich in extracellular matrix molecules also contains a mesenchymal stem cell population that is rather primitive. These WJ mesenchymal stem cells or WJMSCs have excellent potential for…

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Heart Muscle Cells Produced from Induced Pluripotent Stem Cells Repair Heart Attacks in Pigs

Heart Muscle Cells Produced from Induced Pluripotent Stem Cells Repair Heart Attacks in Pigs

When heart muscle cells are made from embryonic stem cells, they integrate into the heart and form proper connections with other heart muscle cells. Such experiments have been conducted in mice, guinea pigs, and nonhuman primates (i.e. monkeys). Chong and others earlier this year (Nature(2014) 510, 273-277) implanted heart muscle cells produced from embryonic stem cells into the hearts of…

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Conditioning Stem Cells to Survive in the Heart

Conditioning Stem Cells to Survive in the Heart

After a heart attack, the heart is a very inhospitable place for implanted stem cells. These cells have to deal with low oxygen levels, marauding white blood cells, toxins released from dead or nearly dead cells, and other nasty things.

Getting cells to survive in this place is essential if the cells are going to provide any healing to he heart. Fortunately, a Chinese group has discovered that…

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Stem Cell Therapy Replaces Dead Heart Muscle in Primates

Stem Cell Therapy Replaces Dead Heart Muscle in Primates

The laboratory of Charles Murry at the University of Washington has used embryonic stem cells to make heart muscle cells that were then used to regenerate damaged hearts in non-human primates. This experiment demonstrates the possibility of using heart muscle cells derived from pluripotent stem cells, but it also underscores the many challenges that still must be overcome.

When the heart…

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Nonhematopoietic Stem Cells from Umbilical Cord Blood Improve Heart Function After a Heart Attack

Nonhematopoietic Stem Cells from Umbilical Cord Blood Improve Heart Function After a Heart Attack

Xin Yu, who has dual appointments at Case Western Reserve University, in Cleveland, Ohio and the University of Minnesota Medical School in Minneapolis, Minnesota, has published a remarkable paper in the journal Cell Transplantationthat describes the use of a stem cell population from umbilical cord blood to treat mice that had suffered heart attacks. The non-invasive way in which these cells were…

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