[Chrysophanol alleviates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and inhibiting M1 macrophage polarization] - Research
Objectives: Sepsis-associated acute kidney injury (SA-AKI) is a major cause of mortality in critically ill patients. Imbalanced macrophage polarization plays a crucial role in the progression of SA-AKI, in which classically activated M1 macrophages aggravate renal injury by releasing pro-inflammatory cytokines, whereas mitochondrial homeostasis disruption is a key driver of macrophage…













