Vitamin E: good for the heart, bad for the bones?
"2005 report from the Centers for Disease Control and Prevention found that one in nine adults takes more than 267 mg per day of vitamin E, even though the daily recommended dose is only 15 mg per day." ...
"Finally, the authors found that rats or mice fed α-tocopherol for eight weeks at doses that are present in the vitamin E supplements used by many people showed a 20% decrease in bone mass and had increased bone resorption and osteoclast size." ...
"Should people, especially those at risk for osteoporosis, continue to take vitamin E supplements based on these current results? Will the benefits of vitamin E on cardiovascular health outweigh the risks for bone metabolism that the authors associated with high vitamin E intake? Given the previous studies that have suggested that vitamin E can influence bone formation and bone resorption, only carefully conducted clinical trials in humans will be able to resolve these questions."
Source: G. D. Roodman, Vitamin E: Good for the heart, bad for the bones? Nat. Med. 18, 491–492 (2012).