For other uses, see Sclerosis (disambiguation). Not to be confused with Scoliosis. In medicine, sclerosis (also spelled sclerosus in the names of a few disorders; from Greek σκληρός "hard") is the stiffening of a structure, usually caused by a replacement of the normal organ-specific tissue with connective tissue. Types include: Amyotrophic lateral sclerosis, sometimes known as Lou Gehrig's disease, a progressive, incurable, usually fatal disease of motor neurons. Atherosclerosis, a deposit of fatty materials, such as cholesterol, in the arteries which causes hardening. Focal segmental glomerulosclerosis is a disease that attacks the kidney's filtering system (glomeruli) causing serious scarring and thus a cause of nephrotic syndrome in children and adolescents, as well as an important cause of kidney failure in adults. Hippocampal sclerosis, a brain damage often seen in individuals with temporal lobe epilepsy. Lichen sclerosus, a disease that hardens the connective tissues of the vagina and the penis. An autoimmune disorder. Liver sclerosis is a common misspelling of cirrhosis of the liver. Multiple sclerosis, or focal sclerosis, is a central nervous system disease which affects coordination. Osteosclerosis, a condition where the bone density is significantly increased. Otosclerosis, a disease of the ears. Systemic sclerosis (progressive systemic scleroderma), a rare, chronic disease which affects the skin, and in some cases also blood vessels and internal organs. Tuberous sclerosis, a rare genetic disease which affects multiple systems. Primary sclerosing cholangitis, a hardening of the bile duct by scarring and repeated inflammation. Primary lateral sclerosis, progressive muscle weakness in the voluntary muscles. ^ "Welcome To The NephCure Foundation". Archived from the original on 2009-06-02. ^ "Focal sclerosis definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms". Medterms.com. 2012-09-20. Retrieved 2013-01-12.
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