The aim of the present study is to evaluate the therapeutical potential of in-vivo and in-vitro plants of Cleome gynandra L. in alleviating diabetes by assessment of body weight and blood glucose level of STZ-induced diabetic rats. Ethanolic shoot extracts of C. gynandra used in the traditional management of diabetes. Nicotinamide 120mg/kg was used as a positive control. A glucometer was used for blood glucose level measurement and body weight was measured by weighing balance at intervals. Total cholesterol and triglycerides of the lipid profile were analyzed. Treatment of STZ-induced Wistar diabetic with the ethanolic plant extracts of C. gynandra (500mg/kg) compared to the glibenclamide standard drug, the in-vitro plant extracts of C. gyanandra were best reacted against body weight reduction and when compared to in-vivo shoots caused significant (P