May 2
CALB2 mediates tumor progression and immune escape in colorectal cancer by shaping an inhibitory immune microenvironment - Research
Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, characterized by a highly immunosuppressive tumor microenvironment (TME) that facilitates immune evasion and tumor progression. Methods: Integrated analysis of TCGA and GEO datasets was performed to evaluate CALB2 expression and its prognostic significance in CRC. Functional experiments including…
#Apoptosis#CALB2#Cancer#CD8-Positive T-Lymphocytes / immunology#Cell Line#Cell Movement#Cell Proliferation#Chaonan Huangfu#Chemokine CCL5 / metabolism#colorectal#Colorectal Neoplasms* / genetics#Colorectal Neoplasms* / immunology#Colorectal Neoplasms* / metabolism#Colorectal Neoplasms* / mortality#Colorectal Neoplasms* / pathology#Disease Progression#doi:10.3389/fimmu.2026.1791363#escape#Female#Gene Expression Regulation#humans#Immune#inhibitory#Macrophages* / immunology#Macrophages* / metabolism#mediates#MEDLINE#microenvironment#National Center for Biotechnology Information#National Institutes of Health