#cell proliferation

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Forces and Signals

The leg folds of a fruit fly provides a model for studying how the mechanical forces resulting from cell proliferation co-ordinate with the pathway of molecular signals called NOTCH to precisely shape epithelial tissue into 3D organs during embryo development

Read the published research article here

Image from work by Alonso Rodríguez and colleagues

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Development, April 2024

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[year-of-the-rabid-dog]

|Cell Proliferation|

Artist; T-Koni

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TRPS1 as possible unique biomarker for triple-negative? Investigations on cellular biology and mechanisms

The mammary gland is a complex tissue comprising a variety of cell types. Their proper functioning is crucial for the health of the breast. Breast cancer is the widest condition affecting breast health and can be categorized as estrogen receptor (ER)/progesterone receptor (PR)-positive luminal, human epidermal growth factor receptor 2 (HER2)-positive, or triple-negative breast cancer (TNBC) types…

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Breast tumor enlarges the carcinogen list: chemical suspects are more than what was thought

Recent statistics indicate that breast cancer is the most prevalent form of cancer and the major cause of cancer-related mortality among women across the world. In the U.S., the lifetime risk of women developing breast cancer is double that of the risk of developing lung cancer. Furthermore, the incidence of breast cancer among younger women is increasing, with mortality rates due to breast…

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Doomeotic regulations of tumors: is it a hoax or a HOXA member to decide the breast cancer destiny?

Doomeotic regulations of tumors: is it a hoax or a HOXA member to decide the breast cancer destiny?

HOXA5 is found in the cells lining the breast, where it normally acts as a tumor suppressor and transcription factor. It helps new cells mature towards performing their final functions. The loss of HOXA5 causes cells to get stuck in their incomplete differentiation phase, during which they start dividing too much. This can lead to cancer. HOXA5 expression is lost in approximately 60-70% of all…

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Fighting endometrial cancer: it's imperative for survival signaling not even to wERK 5 more minutes

Fighting endometrial cancer: it’s imperative for survival signaling not even to wERK 5 more minutes

Endometrial cancer is the most common type of gynecological cancer and is the fourth most common type of tumor in women in developed countries. Although it has a good prognosis if detected early, advanced and aggressive cases have a high mortality rate and are often resistant to standard chemotherapy treatments. Now, a study published in the journal Cellular and Molecular Life Sciences identified…

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Former orphan TLX becomes unique for its effects while triple-negative falling into its nuclear nets

Former orphan TLX becomes unique for its effects while triple-negative falling into its nuclear nets

Breast cancer is categorized into three major subtypes: hormone receptor-positive, HER2-positive, and triple-negative. Although there are targeted therapeutic approaches for the first two, there are limited options for triple negative-breast cancer patients. In a new study, researchers have discovered that the nuclear receptor TLX can potentially be used for therapeutic intervention. Researchers…

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The role of serotonin in cancers: from carcinogenesis, to cellular growth and the influence of immunity

The role of serotonin in cancers: from carcinogenesis, to cellular growth and the influence of immunity

Introduction Serotonin is a neurotransmitter well known for its positive effects on mood. In depressed people, the concentration of serotonin in the brain can decrease. The hormone also affects many other functions throughout the body. Most serotonin is not found in the brain, but is stored in platelets. Serotonin reuptake inhibitors (SSRIs), used to treat depression, increase serotonin levels in…

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