Read the full paper at: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=49653 DOI: 10.4236/ajps.2014.519302 Author(s) Kartini Ahmad, Siow-Ping Tan, Mohd Aspollah Sukari, Abdul Manaf Ali, Mohd Azlan Nafiah Affiliation(s) Department of Chemistry, Faculty Science and Mathematics, University Sultan Idris, Tanjong Malim, Malaysia. Department of Chemistry, Faculty Science and Mathematics, University Sultan Idris, Tanjong Malim, Malaysia. Department of Chemistry, Faculty Science, University Putra Malaysia, Serdang, Malaysia. School of Biotechnology, Faculty of Agriculture, Biotechnology & Food Science, University Sultan Zainal Abidin, Kuala Terengganu, Malaysia. Department of Chemistry, Faculty Science and Mathematics, University Sultan Idris, Tanjong Malim, Malaysia. ABSTRACT Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds, mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3mg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay. gjreww140916 KEYWORDS Carbazole, Rutaceae, Murraya koenigii, NMR, Cytotoxic
