Mar 23
Bie-Jia-Jian Pill: Inhibiting Tumor Glycolysis and Promoting CD8+ Cell-Mediated anti-tumor Immunity by Targeting HIF-1α-PI3K/AKT/mTOR and CCL20 in Hepatocellular Carcinoma - Research
Ethnopharmacological relevance: The efficacy of immunotherapy for hepatocellular carcinoma (HCC) is often limited by an immunosuppressive tumor microenvironment (TME), largely driven by tumor metabolic reprogramming (the Warburg effect) that impairs CD8+ T cells. Targeting this metabolism to restore immunity is a promising strategy. Bie-Jia-Jian Pill (BJJP), a traditional formula for “softening…
#antitumor#BieJiaJian#carcinoma#CCL20#CD8#cellmediated#doi:10.1016/j.jep.2026.121554#Glycolysis#hepatocellular#HIF1αPI3KAKTmTOR#immunity#inhibiting#MEDLINE#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#NIH#NLM#Pill#pmid:41866005#Promoting#PubMed Abstract#research#Songqi He#targeting#tumor#Xuemei Yang#Yang Liu