Dec 25, 2025
CD58 reshapes the immunosuppressive microenvironment in gliomas through PD-L1 upregulation - Research
Background: Cluster of Differentiation 58 (CD58), a critical immune regulator, is implicated in tumor immune evasion, yet its role in remodeling the immunosuppressive microenvironment of gliomas and regulating programmed death-ligand 1 (PD-L1) remains unclear. This study aimed to elucidate the clinical and mechanistic significance of CD58 in gliomas. Methods: This study integrated…
#CD58#doi:10.3389/fonc.2025.1658467#gliomas#immunosuppressive#MEDLINE#microenvironment#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#NIH#NLM#PDL1#Pengfei Zhao#PMC12719248#pmid:41438981#PubMed Abstract#research#reshapes#Siqi Gou#upregulation#Wei Wei