#choleste

[afreelancers-aide-memoire]

PCSK9 enzyme

Proprotein Convertase Subtilisin/Kexin type 9

It is the ninth member of Subtilisin protease family.

It plays a major regulatory role in cholesterol hemostatsis.

It is an enzyme that binds to low-density lipoprotein receptors (LDL receptors), which stops LDL being removed from the blood, leading to an increase in blood levels of LDL. 

The PCSK9 inhibitor [Alirocumab &  Evolocumab] blocks the PCSK9 enzyme, resulting in more LDL receptors available to remove LDL from the blood, which produces in a decrease in LDL blood levels.

Impact of PCSK9 inhibitors treatment:

↓ LDL cholesterol (50-60%)

↓ triglycerides  (8-20%)

↓ total cholesterol (25-40%)

↑ HDL cholesterol (5-9%)

[andrewoferral-blog]

If you are like me you probably thought diabetes is one of those things you have or don't have; nothing could be further from the truth because diabetes is now the biggest threat to health in the developed world and we are eating ourselves into it because of poor diet.