#chondrocyte

[medicomunicare]

No pain, no gain: not true for ion flows regulating cartilage loss in osteoarthritis

Osteoarthritis (OAS) is characterized by cartilage degeneration with the loss of the extracellular matrix that allows the joint to compress without damage. The chondrocytes in OAS show multiple alterations in their metabolism. These occur as part of the chondrocyte response to both external mechanical and internal biochemical stimuli. Chondrocytes also produce multiple inflammatory and enzymatic…

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[medicomunicare]

Limb osteoarthritis: while pain exploits mastcells to make "kneel", talarozole could be a new remedy "at hand"

Limb osteoarthritis: while pain exploits mastcells to make “kneel”, talarozole could be a new remedy “at hand”

More than 40% of individuals will develop osteoarthritis (OA) during their lifetime. Hand osteoarthritis is a common and debilitating medical condition that affects mainly women, especially around the time of the menopause. Despite often being dismissed as just a few aches and pains, OA can have a profound and far-reaching impact on life, affecting people’s ability to work, care for a family, or…

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[medicomunicare]

Tabagism and vertebral disc degeneration: are there relationships and mechanisms?

Tabagism and vertebral disc degeneration: are there relationships and mechanisms?

Cigarette smokers have a higher risk of low back pain which can be caused by disc degeneration and spinal instability. Ischemia, apoptosis, erroneous synthesis of disc macromolecules and an imbalance between matrix proteinases (MMPs) and their inhibitors (TIMPs) may be involved in the pathogenesis of disc degeneration. Along with degeneration, the disc, which by its nature has no blood vessels,…

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[medicomunicare]

Knocking out immunity while leaving neutrophils alone: a drug combo with APPArent selectivity

Knocking out immunity while leaving neutrophils alone: a drug combo with APPArent selectivity

To be healthy, we need an effective immune response, otherwise we would succumb to overwhelming infection, even by everyday bacteria. However, sometimes our immune system can become hyperactive and cause damage through inflammation, even in the absence of any infection. This can sometimes be extreme. Indeed, many rheumatic diseases such as rheumatoid arthritis and osteoarthritis are caused by…

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[singlecellanimation]

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An animation of a group of Chondrocytes * They produce and help maintain the cartilage tissue in our body. They go around filling in areas with a matrix of collagen fibers found in connective tissue such as bones, ligaments, tendons, and cartilage. * #chondrocyte #cartilage #bones #tendons #ligaments #bonejoint (at Denver, Colorado) https://www.instagram.com/p/BrfRJ9FhZn1/?utm_source=ig_tumblr_share&igshid=1atd9auwrrxm0

[postorbital]

At age 11, once their skulls were estimated at full size, the settlers took chondrocyte-altering drugs to stop their skeletal growth, and redirect it to skeletal repair. Few adults were taller than five feet. They ate very little and kept their ceilings low.

[juliaghoulia]