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Diacyl-glicerol in cancer and neuronal cells: specific effects rely on downstream targets
Introduction: Protein Kinase C Cellular proliferation is a highly complex process driven by specific signals that stimulate cells to replicate and generate “daughter” cells, or copies of themselves. Among the various tissues in the body, there are those that are subject to continuous renewal (e.g., bone marrow, skin, internal mucosa, nails) and, therefore, have a high proliferative rate. Cell…
Management anzi-tempo del diabete tipo 1: i risultati di un trial clinico presentati a congresso
Dal 15 al 19 di questo mese di Settembre, la splendida Vienna ha ospitato il Congresso annuale della Associazione Europea per lo Studio del Diabete (EASD), dove sono stati presentati centinaia di posters su ricerca e clinica relativi a questa condizione. Sono stati pubblicati alcuni risultati in via ufficiosa e qualcuno di essi ha attirato l’attenzione di questa redazione scientifica. Una nuova…
The signaling hub won't PIPe down: p53 pipping inositides to drag them into the "core" Akts
Several types of signalosome have been ununcovered in the past twenty years about intracellular signaling; and many more will be surely discovered in the future. P53 ina famous tumor suppressor that intereacts with tens of proteins either inside and outside the nucleus. It is used as a scaffold to recruit dozens of proteins involved in DNA repair, cellular differentiationa and programmed cell…
Finding the Tau of leukemia: the TAUTological focusing on glucose metabolism was not foreseen
A new scientific study identified taurine, which is made naturally in the body and consumed through some foods, as a key regulator of myeloid cancers such as leukemia, according to a paper published in the journal Nature. The Wilmot Cancer Institute investigators at the University of Rochester were able to block the growth of leukemia in mouse models and in human leukemia cell samples by…
Tegaserod: da farmaco contro l'intestino irritabile a nuova arma contro il carcinoma prostatico
Il cancro alla prostata (PCa) è il tipo di tumore maligno maschile più diffuso e la principale causa di morte per cancro tra gli uomini a livello globale. Indipendentemente dalla suscettibilità iniziale alla terapia di deprivazione androgenica (ADT), la maggior parte dei pazienti sviluppa un cancro alla prostata resistente alla castrazione (CRPC) entro 18-36 mesi dal trattamento. Pertanto, vi è…
From Systems to Cells: A Regenerative Model of Healing and Health | ChatGPT4o
[Download Full Document (PDF)] This document presents a comprehensive exploration of a regenerative model of healing and health, emphasizing the interconnectedness of biological, psychological, social, and ecological systems. The introduction highlights the crisis of coherence within living systems, proposing that health is defined not just by the absence of disease but by the presence of…
Omega-6 amici del tumore mammario: ecco come fa l'acido linoleico a stimolare la crescita
L’acido linoleico (polinsaturo omega-6) è un nutriente derivato dalla dieta che è considerato essenziale nei mammiferi per supportare molteplici processi corporei. Tuttavia, l’abbondanza di questo grasso nella dieta “occidentale” è aumentata in modo significativo dagli anni ’50, in concomitanza con il maggiore utilizzo di oli di semi in cibi fritti e ultra-lavorati. Ciò ha portato a…
AML fighting is not just BH-3: SRChing target protein kinases to TORCh 1 or 2 more Akts
Acute myeloid leukemia (AML) is the deadliest form of leukemia, with a median survival of less than nine months and a five-year survival rate of just above 30%, according to the National Cancer Institute. AML represents a disease that develops from the uncontrolled growth and survival of undifferentiated leukemia stem cells. These stem cells are particularly dependent for survival upon the MCL-1…
