#cold pain

[moefling-malec]

Cold Pain

Author: Aramandria

Summary: (summary for this fic is just an excerpt for the fic) 

Luke took a deep breath, “How are you doing Alec?”

He nodded but kept his gaze out of the window, “I’m good. A few aches here and there but the doctor has given me the green light and Jace and I have been training together again. I’m pretty much there”. He turned back to Luke and saw his raised eyebrow.

“That’s great, I’m glad you’re healing physically. I have to admit that wasn’t something I was particularly concerned with, you’re too damn stubborn to let that beat you”. He breathed in loudly through is nose. “I was more concerned with your mental health…”.

My Rating: 2.5/3

Thoughts: i want to give this a 3/3 but there is just a few *tiny* things i don’t like so i can’t quite give it to this fic...

i really enjoyed this fic but if you watched Shadowhunters i promise you will spend the ENTIRE fic wondering is Sebastian is a good guy or a bad guy... (no spoilers so thats all i’ll say except that i honestly went back and forth the entire time until the exact moment the bad guy was revealed)

the only things i’d change is the fic starts out focusing more on Alec’s mental health and the angst related to it (which i love) but as the story goes on and especially as the story reaches the climax suddenly there isn’t much of that anymore (specifically i’m calling out the fact that Alec is injured pretty badly but he just kinda keeps going without much comment)

and just one more thing that bothers me is the epilogue.  generally i like the epilogue to wrap things up for the story but this one just pushes that you have to read the sequel (which i will read when it finishes but it makes me a little mad because the story doesn’t wrap up it leaves it on a cliff hanger)

still a good fic and i’ll be reading it again  

[bookpiofficial]

Thermo-TRP Channels in Pain Sensation: An Overview | Chapter 03 | Modern Advances in Pharmaceutical Research Vol. 3

The perception of temperature is a major component of sensory experience of animal and human organisms. A sensitive response of the nervous system to changes in temperature is of predominant importance for homeo-therms to maintain a stable body temperature. Recent investigations in central and peripheral thermosensitivity have emphasized the importance of temperature-activated transient receptor potential (TRP) cation channels and they are being ardently pursued as targets for analgesic drug discovery. They are the largest group of sensory detectors expressed in nerve terminals and pain receptors activated by temperature and provide information about thermal changes in the environment. These temperature sensitive or thermo-TRP channels (TRPA1, TRPM8, TRPV1, TRPV2, TRPV3 and TRPV4) have been characterized to date that exhibit sensitivity to increases or decreases in temperature as well as to chemical substances that elicit similar hot or cold sensations. The thermal thresholds of many thermo-TRP channels are known to be modulated by extracellular mediators, released by tissue damage or inflammation. Antagonists or blockers of these channels are likely as promising targets for new analgesic drugs at the periphery and central levels and thus, controlling the modulation of thermo-TRP channels by inflammatory mediators and ligands may be a useful alternative strategy in developing novel analgesics.

Author(s) Details

Merab G. Tsagareli Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, Tbilisi 0160, Georgia.

View Volume: http://bp.bookpi.org/index.php/bpi/catalog/book/133

[bookpiofficial]

TRP Channels in Physiological Nociception and Pain | Chapter 01 | Modern Advances in Pharmaceutical Research Vol. 3

The Transient Receptor Potential (TRP) channel superfamily is comprised of a large group of cation-permeable channels, which display an extraordinary diversity of functions from sensory signaling to animal behaviors. These channels are ‘cellular sensors’ that respond to changes in the cellular environment, including temperature, stretch/pressure, chemicals, oxidation/reduction, osmolarity and pH, and of spices, venoms and toxins. The role of TRPs will be further elucidated in complex diseases of the nervous, intestinal, renal, urogenital, respiratory and cardiovascular systems. Although the physiological functions of most TRP channels are not well known, their wide distribution in cellular membranes indicates that the biological functions and activation mechanisms for these channels are diverse and important. In this paper we review our recent findings of activation different TRP channels evoked by chemical irritants such as cinnamon aldehyde and mustard oil for TRPA1, menthol for TRPM8 and capsaicin for TRPV1 by a battery of behavioral tests.

Author(s) Details

Ivliane Nozadze Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, 0160 Tbilisi, Georgia.

Merab G. Tsagareli Laboratory of Pain and Analgesia, Beritashvili Center for Experimental Biomedicine, 0160 Tbilisi, Georgia.

View Volume: http://bp.bookpi.org/index.php/bpi/catalog/book/133

[roughlandingholly]

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