Ferre, do you have a moment? There’s.. something on my mind. I feel as though I’ll go mad if I don’t talk to someone, and you seemed to me the best person to come to.
Since finals, I’ve been thinking a lot about how medicines are often also poison.
Derivatives of foxglove and nightshade are both used to treat heart conditions. Warfarin—also used as rat poison—is used as an anticoagulant. And of course, many medicines are lethal in too high of doses.
Since I’m working towards becoming an oncologist, I’m mainly thinking about this in the context of chemotherapy. Chemotherapy treatments today are far, far better than they were even a decade ago, but they’re still poisons.
The goal with chemotherapy isn’t exactly to heal the patient. It’s to kill the cancer faster than you kill the patient. Chemo is cytotoxic—it kills cells. That’s its job.
Doxorubicin is known for damaging heart function. Cyclophosphamide damages the bladder. Most chemotherapy attacks bone marrow, nearly eliminating the patient’s immune function. That’s not to mention the simple discomfort associated with chemo drugs—pain, fatigue, nausea.
You know I’ve always wanted the good to be innocent. I like the idea that I can help people without causing pain along the way. I still have hope that in many areas of life, this is possible. But not here. Not yet, anyway. With the current standard treatments, I’ll need to poison my future patients in order to heal them. That doesn’t sit well with me.
What’s the takeaway? I’m not sure. I guess it’s just a reminder that there’s still so much work to be done. Hopefully I can help with more research studies related to less dangerous cancer treatments next year. Maybe even alternatives to cytotoxins altogether, though that’s possibly wishful thinking.
I mostly just wanted to ramble. That’s what tumblr is for, right? It feels good to write all that out.