Something that I really like about blades in the dark is the fact that in the main setting you are unable to run. The city of Duskvol is locked down, and the only real ways out are the trains or jumping ship so running isn't the easiest thing to do, and its harder to come back.
Something that happened in the old campaign that I was running was that all the people in it were running from something, and needed to get away. This kinda drove how I thought about the campaign itself, and I think it is just a fun way to drive things forward in general, that being the crew is running from either something very big or a bunch of little things, but they are running, and eventually the whole city will come crashing down upon them, and in their desperate fight to get away they topple more, and more onto their ever growing pile of things that are after them.