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He Jiankiu didn't really gene edit those girls; he mutated them

He Jiankiu didn’t really gene edit those girls; he mutated them

Did Chinese researcher He Jiankui really CRISPR gene edit the CCR5 gene in two embryos producing twin baby girls? In my opinion the answer is “no”, but probably not for the reason you might think at first.

He proclaims gene edits

He claimedhe had made twin baby girls with “gene edits”, which I feel is unethical overall and risky to those babies. He’s announcement also may have been intentionally…

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#CRISPR #CRISPR human embryos #CRISPR indels #gene editing #He Jiankui #human CRISPR #human gene editing #Human genome editing #human germline editing #Jiankui He #Mark Yarborough #UC Davis bioethics

4 key reasons Mitalipov paper doesn't herald safe CRISPR human genetic modification

4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification

We can be confident that human genetic modification via CRISPR’ing of embryos soon will be safe and effective after that new exciting Mitalipov team paper, right?

Wrong.

The reality is far more complicated and interesting on the tech side.

In a nutshell, I see the paper as a significant scientific, but not necessarily medical advance.

The media coverage overall has painted too rosy and simplistic…

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#CRISPR indels #CRISPR mosaicism #CRISPR off targets #familial hypertrophic cardiomyopathy (HCM)#human CRISPR #human gene editing #human genetic modification #human mosaic #Jin-Soo Kim of the Institute for Basic Science in Daejeon South Korea #Keith Joung #MYBPC3 #Shoukhrat Mitalipov

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