#gene editing

[reasonsforhope]

Type 1 Diabetic Produces His Own Insulin After Gene-Edited Cell Transplant

Three changes in total to the genetic code were needed to ensure the transplanted donor cells didn't trigger an immune response.

"A patient with type 1 diabetes has become the first in the world to produce his own insulin via transplanted cells edited with CRISPR.

The edits halted his own immune system from attacking the cells, leading to production of insulin in the pancreas as if he never had the disease in the first place.

Unlike the rampant type 2 diabetes, type 1 manifests as an autoimmune disorder whereby the patient’s immune system attacks and destroys a type of cell created in the pancreas to produce insulin, known as islet cells. 9.5 million people worldwide suffer from type 1 diabetes and there is no cure.

The standard of care beyond daily insulin injections involves using donated islet cells to allow a patient’s metabolism to function normally, followed by medications used to prevent the immune system from attacking those cells. These medications have harmful side effects.

A team of biomedical researchers primarily from Uppsala University, Sweden, in collaboration with UC San Francisco, successfully used the CRISPR gene-editing method to take a donor’s islet cells and modify them so as to evade prosecution by the patient’s immune system.

Three changes in total to the genetic code were needed to ensure the transplanted donor cells didn’t trigger an immune response, including changes to cell membrane signal proteins used as a sign of attack by white blood cells.

CRISPR TO THE RESCUE:

Infant With Incurable Disease is First to Successfully Receive Personalized Gene Therapy Treatment

Aggressive Leukemia Disappears in 13-Year-old Girl Who was First to Receive New CRISPR Treatment

First Patient to Receive Gene Therapy ‘Cure’ for Beta-Thalassemia Living Pain-Free

As a preliminary study, the man received only a small amount of the donated, modified cells, meaning he still requires daily insulin injections. However the results show that the cells produced their own insulin and remained unperturbed by the immune system.

After 12 weeks, the cells were still producing endogenous insulin, setting the stage for longer-term and more robust experiments in the future.

The study was published in the New England Journal of Medicine."

-via Good News Network, August 25, 2025

[crylandgrace]

Morally grey Rocky who edits Grace's genes without permission. Maybe he read about CRISPR-Cas on the portable earth thinking machine, and realised that he could possibly, feasibly, extend his human's life span beyond the expected range. Making sure the cells' telomeres are replenished, filtering out free radicals, keeping his human on a healthy diet, he wants to try it all. Maybe he figures out how to make it work- after all, they've got Grace's DNA right here for production of those me-burgers. Grace has expressed before that he doesn't want to experiment with himself like that, it's too risky, too much of a change to scramble up his fundamental building parts and kill him right there, and even though he isn't religious anymore, it feels wrong to play god like that. Rocky doesn't like that. Can't accept that. Grace is the best thing that happened to him, and he can't allow his human to die before they get to spend proper time together. Getting the new genome into Grace is a massive undertaking, and unfortunately cannot be executed while keeping the human ignorant. But what needs to be done has to be done. So he harvests stem cells, Grace under anaesthetic with the excuse of some other, non-invasive, low-risk exploration. He edits them. But then he has to put them back in to Grace, needs them to override the original cells. And there's no easy way to do that. He develops chemotherapy specifically to eradicate Grace's cells so he can replace them. It leaves the human horribly ill, nearly iller than he was on their last leg of the journey to Erid, and miserable. But it has to be done. Grace isn't stupid, but he doesn't exactly know what's going on. He just knows that he's getting ill and that he needs treatment, but he doesn't know that the 'treatment' is the cause, that it's on purpose. When the chemotherapy is sufficient, the new and improved stem cells get introduced, and then it's a waiting game. Grace is closely monitored, so Rocky knows that the cells are successfully transplanted and doing their work, but up until this point it has all been theoretical. This could kill Grace. But Rocky knows that it won't, because his intelligence and craftsmanship and the team of Eridians he's manipulated into working on this with him will not fail him. Grace will live. He just has to wait and see. And wait for Grace to realise that he's not the same human he once was, realise that he was used as a very precious lab rat. Grace may not want to talk to Rocky anymore once he figures it out. But that'll be okay, because Rocky will have until that point to be around Grace, and, Grace will still be on Erid, so he will never truly be out of Rocky's hearing. In every scenario, Rocky wins.

[amber-tortoiseshell]

We got colorpoint/ temperature sensitive albino cats, rats, mice, rabbits, dogs, guinea pigs, squirrels, even saw a bird example. What's keeping us from colorpoint horses? Is that something we could theoretically genetically engineer, similar to how the albino anole was made? You could almost have a colorpoint pet of every common mammal at this point (ha)

The gene-edited anoles article was very interesting, thank you for bringing it to my attention!

Making an albino is generally easier than making a colorpoint, because knocking out a gene is easier than editing a single nucletide - but it can be done! Single base editing exists. So yeah, at the very least we could try to replicate the mutations of other colorpoint animals is a horse, and see if they turn out pointed here too.

[hope-for-the-planet]

Could this gene hold the secret to growing rice in a warming world? -…

From the article:

A team of scientists in China recently announced that they had identified a gene that, when overheated, appears to have a negative impact on crops, lowering yield and producing chalky-looking, pasty-tasting grains. But when that gene is deactivated — through gene editing or through breeding that capitalizes on a naturally occurring variant that doesn’t react to higher temperatures — rice plants produce more and better grains, according to a peer-reviewed paper published last month in the journal Cell. The finding represents “a breakthrough for breeding high-yield, superior rice varieties resilient to rising temperatures,” emailed Yibo Li, the paper’s lead researcher and a plant geneticist with Huazhong Agricultural University in China. Outside experts said there could be great potential in being able to tweak a single gene that is responsible for controlling both yield and quality.

[dandelionsresilience]

Good News - July 8-14

Like these weekly compilations? Tip me at $Kaybarr1735! And if you tip me and give me a way to contact you, at the end of the month I'll send you a link to all of the articles I found but didn't use each week!

1. Zoo welcomes birth of four endangered horse foals

“[The Marwell Zoo in GB] said it was "delighted" to welcome the arrivals to the endangered Przewalski’s horse herd. All four are female and said to be "doing well" after two were born in May and two in June. […] “These horses, that were previously listed extinct in the wild, are an example of how zoo breeding programmes can help restore threatened species around the world.” […] All the Przewalski’s horses alive today are descended from just 12 individuals. Current estimates suggest there are 178 mature individuals living in the wild.”

2. Restoring woodlands and planting trees for sustainability success

“In 2023, [the Marwell Zoo] planted 9,000 new trees […] both within the zoo and on our surrounding land. […] Marwell tries to encourage natural feeding behaviour and nutrition by including leafy material [in animals’ feed] as much as possible. […] Planting more trees and enhancing management of our existing woodlands, prepares the way to further self-sufficiency in browse production in the future. Plus, it creates new habitats for wildlife in our woodland areas.”

3. Inclusive Playgrounds Allow Children Of All Abilities To Play

“With ramps allowing children in wheelchairs to ascend the central play structure, as well as numerous other swings and apparatus usable for children of all abilities, the 16,000-square-foot P.K.’s Place is St. Paul’s first fully inclusive playground. […] To be universally accessible, a play area must have at least 70% of its play features fully accessible, far more than required by the Americans with Disabilities Act (ADA). […] Play areas should allow parents and grandparents with disabilities to participate as well.”

4. Combination treatment can increase human insulin-producing cells in vivo

“[Diabetes-model mice] were treated with the combination therapy [of a plant product called harmine and “a widely used class of type 2 diabetes therapy”] and their diabetes was rapidly reversed. Strikingly, human beta cell numbers increased by 700 percent over three months with this drug combination. "This is the first time scientists have developed a drug treatment that is proven to increase adult human beta cell numbers in vivo. This research brings hope for the use of future regenerative therapies to potentially treat the hundreds of millions of people with diabetes," said Dr. Garcia-Ocaña, the paper's corresponding author.”

5. Decades of Dedication: Australia’s Largest Ongoing Urban Restoration Project

“[Friends of Lake Claremont] has transformed the area into a thriving ecosystem, re-establishing native habitats and fostering biodiversity. This year, 800 native seedlings (100 trees, 350 shrubs and 350 ground covers) have been planted on the northwestern buffer of Lake Claremont. Volunteers replaced a large Port Jackson fig (Ficus rubiginosa) affected by [beetle] infestation with native plants to enhance the local wildlife habitat, thereby benefiting insects, frogs, birds and brown bandicoots. […] Overall, the project contributes to the area’s function as a regional ecological corridor, linking inland bushlands, the Swan River and the Indian Ocean.”

6. Important habitat for fish in Heart of the Fraser now conserved

“British Columbia’s iconic salmon now have more protected spawning habitat in the lower Fraser River, thanks to the Nature Conservancy of Canada’s (NCC’s) conservation acquisition of Carey Island. […] Carey Island and its gravel channels offer calm and crucial spawning and rearing habitat for the river’s fish and aquatic species. […] The Pelólxw Tribe […is also] actively working to restore the resilience of aquatic habitat within this stretch of the Lower Fraser. NCC is exploring opportunities to collaborate with the Pelólxw Tribe in support of their vision for stewardship of the area, which prioritizes both ecological and cultural values.”

7. Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

“[R]esearchers have developed a gene-editing approach that efficiently corrects the most common mutation that causes cystic fibrosis, found in 85 percent of patients. With further development, it could pave the way for treatments that are administered only once and have fewer side effects. The new method precisely and durably corrects the mutation in human lung cells, restoring cell function to levels similar to that of Trikafta [the standard treatment since 2019].”

8. Montana’s High Court Considers a Constitutional Right to a Stable Climate

“At issue was the appeal of a decision last year, when a Montana judge blocked a state law that prohibited agencies from considering climate impacts when deciding whether to approve fossil fuel projects such as new power plants, pipelines or mining. The ruling, by District Judge Kathy Seeley, was prompted by a lawsuit filed by 16 youths who argued that the law violated Montana’s constitutional right to a “clean and healthful environment.” It was the first ruling in the United States to effectively establish constitutional rights to a stable climate[….]”

9. The US is about to get its first solar-covered canal

“The first canal-based solar project in the U.S. is nearing completion on tribal lands south of Phoenix, Arizona. […] The long, narrow solar array design would snake along the line of the canal and tap into the local electrical distribution grid every 1,000 feet, or every one megawatt. […] “Canal solar allows for greater power production per land size, cleaner water, less power transmission losses, and significant reduction in evaporation[….]” Covering the entire 8,000 miles of canals and waterways managed by the Bureau of Reclamation with solar panels could generate over 25 gigawatts of renewable energy and reduce water evaporation by tens of billions of gallons[….]”

10. Camera traps offer glimpse of first beaver born in Northumberland for 400 years

“"It’s such a relief that they have bred successfully and to see a new fluffy kit swimming with the family[….]” In just one year [since releasing the beavers], there has been a noticeable increase in resident trout, says the National Trust, along with more regular visits from kingfishers and grey herons. There are more insects at the site, too, thanks to the organic matter that builds up behind the dams, which in turn provides food for Daubenton’s bats. […] Beavers also play an important role in creating habitats that are more resilient to the effects of climate change[….]”

July 1-7 news here | (all credit for images and written material can be found at the source linked; I don’t claim credit for anything but curating.)

[floral-ashes]

New publication with my best title yet! Using CRISPR gene editing as an anchor, I offer reflections on high-tech conversion practices, high-tech medical transition, and the ethics of hype.

Link to the paper here.

Link to an audio version here.

[acti-veg]

please can I ask why you are anti eugenics?

as in, why would altering someone’s genes so they don’t have a disposition to develop cancer be bad?

as someone who is pretty sure their genes are responsible for their horrible mental health, if the genes responsible for my disposition towards ocd and depression could have been removed, I don’t see why that would have been bad

wouldn’t it be good if we could alter people’s genes so no one is violent and everyone has a kind & loving nature

I don’t see how that’s a bad thing

I can see how eugenics could potentially be harmful too but I don’t think any of the above would be bad

(just to be very clear, i am NOT advocating for anything horrible like “euthanising the disabled”)

Eugenics is not just gene editing, it is a set of deeply racist, ableist beliefs about human ‘improvement’ on the basis of so-called ‘desirable racial characteristics.’ Eugenics as a concept is inherently wrapped up in white supremacy, homophobia and ableism. It was extremely popular in the west as an idea, it took the Nazis putting it into practice to show us what eugenics in practice actually looks like.

Gene editing sounds good on the basis of curing or preventing human disease, but that is precisely how all controversial science is framed. It is hard to object to editing genes to prevent cancer, but what happens when we start selecting for other traits we deem to be ‘desirable,’ and who gets to decide? The state? Medical professionals? The industrial military complex? Scientists? All of whom have the same biases we all have from being socialised in a deeply prejudiced society?

You say you don’t support anything horrible, but we don’t all agree on what is horrible - what should be kept and what should be lost. Many hearing people would see deafness as uncomplicatedly a medical issue, and assume all deaf people would want a cure. But Deaf culture is vibrant, and many in the community don’t see themselves as in any way needing to be ‘cured.’ Imagine the possibility that someone could edit the potential for anyone else to be part of your group out of the human genome entirely, that we could potentially see cultural genocide of Deaf, disabled and neurodivergent communities done on a systematic scale.

Take depression as an example. Taking away any genetic disposition towards depression is tempting, but then what is to stop us from expanding this same line of reasoning to genetically select for positive dispositions? Is that actually desirable? Taking away the propensity for a natural range of emotions? What would be the an actual impact of that human society? Could we end up ‘curing’ the symptom of a sick society by just editing out the resulting depression, rather than addressing what is actually causing the mental health crisis, beyond just genetics? Could we end up in the dystopia that Huxley envisioned in a Brave New World, but with gene editing instead of soma?

You mention violence, but violence is an evolved response to stressors that is sometimes necessary. I shouldn’t have to spell out why genetically editing a population to be non-violent and good humoured regardless of what is being done to them is bad, and what you’re essentially saying here isn’t very far away from ‘why can’t we edit everyone to be the perfect, passive citizen and consumer?’ Fight or flight is part of our very being, and aggression when it is called for in defence of our loved ones or our own interests is a part of the human condition. Do we really want to lose that? Do we want to cull the propensity for violent resistance from our DNA?

It doesn’t stop at physical traits and overtly negative dispositions, either. We have been able to genetically engineer voles to be monogomous. That is not a joke. Can you imagine what the implications could be for being able to select for behaviours and desires? The state being able to mandate gene editing to avoid disease, slowly turning into gene editing for ‘super soldiers’, then to select for desirable traits in their citizens? Even if democracies wouldn’t do it, history tells us that if the technology is there, someone will.

Before it even gets to the human stages though, animals will bear the brunt of our curiosity. In the famous case of Alba, we created a glowing rabbit for the sake of an ‘art’ project. We have grown an ear on the back of a mouse. We have already selectively bred farmed animals to the point where they suffer constantly, imagine just how horrific it could get if we can edit their genetic sequence cheaply and at scale? Imagine what we would do to them?

These technologies being developed under capitalism brings up even more issues. The wealthy classes have always argued that they are somehow superior, better ‘breeding,’ more intelligent, less lazy. They’ve always been kidding themselves, but genetic editing available only to those who can afford it would make them right. At least initially this technology would be wildly expensive, and before those prices were bought down we’d likely end up with a society that is biologically hierarchical as well as economically and socially. Capitalists would very likely fight to keep it that way, just as they fight to keep themselves economically superior now.

This isn’t just a class issue either, the chances that this technology would be offered to the global population and not just rich western nations are minimal. Environmental racism and cultural ideals could become genetically baked in. We wouldn’t be improving the human race, we’d be ‘improving’ very narrow sections of it, according to a narrow and context dependent definition of what a ‘good’ human looks like. Wealth and social hierarchy could become biologically embedded, with only rich westerners benefiting from these advances. I mean, people in the global south are still dying of malaria, despite us wiping it out in the west in 1950s.

You may dismiss some of this as alarmism, but I think people who are not at least a little bit concerned at these possibilities haven’t thought about the implications of gene editing very much. We’re essentially in the cusp of creating an entirely new species, without really considering what that means. If history tells us anything, it’s that we’re likely to leap into the technology for commercial reasons long before we’ve given proper consideration to the ethical and social implications. That should worry you.

[toastedmooshroom]

Whoever named CRISPR isn't allowed to name anything ever again.

Clustered Regularly Interspaced Short Palindromic Repeats

Half of those words fully do not need to be there.