With the recent cover art for the new run of Marvel Runaways by Stephanie Hans, my old obsession with the tv show of Marvels Runaways has been re-awakened and is mixing with my current obsession with Die. So without further ado, the original Runaways and their Die Classes.
Alex Wilder: Master. Yeah I know it seems like Alex would be best suited to a Neo, he's a hacker in canon after all. However it feels like Alex would be the most likely to be tempted into initiating Die as he was stated in Canon to be interested in RPGS online and was desperate to re-unite his old friends, and I could very easily see him pretend to be a Neo using his masters abilities (could very easily replicate a Neo's hacking abilities using Rules Mastery, specifically Manipulate Mechanism) and equipment (Masters can pick out a handgun as equipment like a Neo) to fit in with his friends or hide the fact that he was the one who instigated the game.
Nico Minoru: Godbinder. Nico in canon is a Wiccan and practitioner of modern paganism, this makes her a perfect candidate for a Godbinder in the world of die, and the class best reflects her varied spell based abilities. You could even set it up with her having a unique Contract with a god who only grants unique miracles if we want to be comic accurate to her powers with the Staff Of One. Her sister could very easily be a fallen in the world of Die for extra heartache and angst.
Karolina Dean: Master. Two masters is a bit risky, but Karolina is meant to be the offspring of the Magistrate (who in this canon would likely be something close to the Grandmaster) and that bloodline would have to give her some unique powers, adding into this the risk element of the Masters spellcasting could be that her use of her powers risks drawing the attention of the Magistrate. Also her range of powers from flight to energy blasts, light generation and shield creation fits best to a Masters versatility.
Chase Stein: Emotion Knight. Chases reliance on a single weapon makes him best suited to be an Emotion Knight, while I could see an argument for Neo due to the Fistigons tech nature. I would disagree as he doesn't seem to use much varied tech in show but instead focues on the Fistigons, Rage knight seems the best suited for him based on his agressive outbursts in response to abuse from his father and it seems like the sort of thing Die would prey on.
Gert Yorkes: Neo. Hear me out, Gertrudes main powers come from her connection to her Velociraptor Old Lace(YEAH), which is a genetically edited dinosaur. One of the gifts of a Neo is a Pet which they can summon and instruct, so I would put Gert as a Neo who invests Solely into Pet as Old Lace.
Molly Hayes/Hernandez: Emotion Knight. As far as I know most of Molly's uses of her powers in the early epiodes came about when she was distressed or surprised which lines up very well for an Emotion knight, I'd make her a Vigilance or Fear knight personally.
A bit of class repeating here but hey, a little bit of messiness fits the Runaways.