#effectors

[kamounlab]

I just published: 2025 the year in review

It’s that time of year when we recap our team’s publications and other highlights.

Check the article here.

[stormwaterwitch]

How did you came up with your elemental system? I've got really inspired by you and want to create something similar, but don't want to steal your work. All things you create, by the way, is really cool!

Heya Anon!

Thank you so much for your kind words!

I go into more about how I came up with my system here:

But the gist of it was I was unhappy with how limiting having 4/5 elements was. (4 being earth wind fire water, 5 including spirit into the mix)

It just felt like there was so much MORE that wasn't being utilized and so i set out to puzzle out exactly WHAT I thought was missing.

IIRC my original list went something like this: Fire Water Air Earth Light Dark Time Space Luck Fate Order Chaos Blood Gravity Lightning

The last three on this list did not make the final cut as I felt like they didn't fit with the themes that the rest all came together to make (That and i decided that my elements would be able to be combined to form any missing elements I was needing (Space+ Earth= Gravity) (Light + Fire = Lightning) Blood was just my way of trying to input a 'Spirit' element lol)

But as for making your own to work with: Figure out WHAT you're trying to get out of what you're working with. When I started with mine I tried thinking about the things that I felt impacted my life on the regular in addition to the traditional 4 elements. Light and Dark came about because of day and night as well as how they help me view the world. Time and Space because I am always somewhere at some point in time and that helped me be more conscious of the world around me. Luck and Fate are the paths that I cannot control that directly influence the direction of where my life is headed. Order and Chaos were my way of explaining the state of things around me/my life.

It took several weeks for me to really gather everything together and have it be how it is so don't get discouraged if you don't stumble upon something right away. Don't be afraid to drop what isn't working for you (like Blood element lmao)

TLDR: Figure out what you'd like to try and experiment with it!

Also protip: I don't own these elements, these are just the way my think brain likes to interpret things so if they speak to you too: Cool!

Thanks again for your kind words and your patience in me getting to this ask!

[kamounlab]

Check our Publications website on Scoop.it -- Updates from the group of Sophien Kamoun at The Sainsbury Lab

[storeinnovacera]

High Purity Alumina Ceramic Handling Arm

[cytgen]

Identification of FtsZ Protein Nucleotide-Binding Site Effectors Based on Cheminformatics and Structural-Biological Analysis - Cytology and

There is a large group of bacterial FtsZ inhibitors whose biological activity has been confirmed biochemically. However, the sites of protei

Abstract There is a large group of bacterial FtsZ inhibitors whose biological activity has been confirmed biochemically. However, the sites of protein–ligand interaction for most of them remain unknown, significantly complicating the further search and combinatorial design of FtsZ inhibitors. This study presents the results of bioinformatic analysis of bacterial FtsZ effectors, the interaction of which has been proven and documented in the ChEMBL database of biologically active molecules. With an integrated approach based on chemo- and bioinformatic methods and AI-based predictions, 23 inhibitors of nucleotide-binding site (NBS), as well as 16 new effectors of the interdomain cleft (IDC), were identified.

[cytgen]

Identification of FtsZ Interdomain Cleft Effectors Based on Pharmacophore Search and Molecular Docking - Cytology and Genetics

Abstract There are a significant number of inhibitors of the bacterial FtsZ protein with biochemically confirmed biological activity, at the

Abstract There are a significant number of inhibitors of the bacterial FtsZ protein with biochemically confirmed biological activity, at the same time, their binding sites remain unclear. This significantly complicates further combinatorial design, and, in the current study, the results of a computational search for effectors of the Inter-Domain Cleft (IDC) site are presented. The actual research was based on the results of pharmacophore screening using the Pharmit service and molecular docking with CCDC GOLD and iGEMDOCK programs. The objective group was a combined library of 379 compounds, which was designed based on revision of the structural database of the RCSB Protein Data Bank and compounds from the ChEMBL database, for which direct interaction with FtsZ has been proven biochemically. According to the results of pharmacophore search, docking, and structural analysis, 88 effectors of the IDC site were identified. One more curcumin compound has been identified as a potential IDC site effector.

[randomrandomalright]

They may not be a big fandom for this show, but I love it! It’s pretty great! Go Effectors!

Check it out if you ever have the chance or watch it online, it needs more attention! Even if it is a bit cringe and childish. :D

[unclejegz]

More on @uncle_jegz • • #biology2 #effectors • #unclejegz #gcse2021 #aqascience #sciencerevision #science #gcse #gcserevision #studygram #year11 #gcseresults #studywithme #Studytime #gcsescience (at Thornton Heath, Bromley, United Kingdom) https://www.instagram.com/p/CCfYWMpgh4g/?igshid=sqacrvn5rkko